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ChemicalBook >> CAS DataBase List >> 4-[4-chloro-5-(3-fluoro-4-methoxy-phenyl)imidazol-1-yl]benzenesulfonam ide

4-[4-chloro-5-(3-fluoro-4-methoxy-phenyl)imidazol-1-yl]benzenesulfonam ide

4-[4-chloro-5-(3-fluoro-4-methoxy-phenyl)imidazol-1-yl]benzenesulfonam ide price.
  • $60 - $1900
  • Product name: 4-[4-chloro-5-(3-fluoro-4-methoxy-phenyl)imidazol-1-yl]benzenesulfonam ide
  • CAS: 265114-23-6
  • MF: C16H13ClFN3O3S
  • MW: 381.81
  • EINECS:
  • MDL Number:MFCD09837875
  • Synonyms:Cimicoxib;4-(4-chloro-5-(3-fluoro-4-Methoxyphenyl)-1H-iMidazol-1-yl)benzene sulfonaMide;4-[4-chloro-5-(3-fluoro-4-methoxy-phenyl)imidazol-1-yl]benzenesulfonam ide;Benzenesulfonamide, 4-[4-chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]-;UR-8880 (Cimicoxib);trade name: Cimalgex;UR8880;UR-8880
Price12 Properties Safety Information Description
12 prices
Selected condition：
Brand
  • AK Scientific
  • Biosynth Carbosynth
  • Cayman Chemical
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number3043CB
  • Product descriptionCimicoxib
  • Packaging2mg
  • Price$131
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC100025
  • Product description4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide
  • Packaging2mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC100025
  • Product description4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide
  • Packaging5mg
  • Price$125
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC100025
  • Product description4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide
  • Packaging10mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC100025
  • Product description4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide
  • Packaging25mg
  • Price$350
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC100025
  • Product description4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide
  • Packaging50mg
  • Price$600
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10006295
  • Product descriptionCimicoxib
  • Packaging1mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10006295
  • Product descriptionCimicoxib
  • Packaging5mg
  • Price$239
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10006295
  • Product descriptionCimicoxib
  • Packaging10mg
  • Price$388
  • Updated2024-03-01
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC31955
  • Product descriptionUR-8880(Cimicoxib)
  • Packaging250mg
  • Price$950
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC31955
  • Product descriptionUR-8880(Cimicoxib)
  • Packaging1g
  • Price$1900
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberC441690
  • Product descriptionCimicoxib
  • Packaging250mg
  • Price$1190
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 3043CB Cimicoxib 2mg $131 2021-12-16 Buy
Biosynth Carbosynth FC100025 4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide 2mg $60 2021-12-16 Buy
Biosynth Carbosynth FC100025 4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide 5mg $125 2021-12-16 Buy
Biosynth Carbosynth FC100025 4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide 10mg $180 2021-12-16 Buy
Biosynth Carbosynth FC100025 4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide 25mg $350 2021-12-16 Buy
Biosynth Carbosynth FC100025 4-[4-Chloro-5-(3-Fluoro-4-Methoxyphenyl)-1H-Imidazol-1-Yl]Benzenesulfonamide 50mg $600 2021-12-16 Buy
Cayman Chemical 10006295 Cimicoxib 1mg $62 2024-03-01 Buy
Cayman Chemical 10006295 Cimicoxib 5mg $239 2024-03-01 Buy
Cayman Chemical 10006295 Cimicoxib 10mg $388 2024-03-01 Buy
DC Chemicals DC31955 UR-8880(Cimicoxib) 250mg $950 2021-12-16 Buy
DC Chemicals DC31955 UR-8880(Cimicoxib) 1g $1900 2021-12-16 Buy
TRC C441690 Cimicoxib 250mg $1190 2021-12-16 Buy

Properties

Melting point :211-212 °C
Boiling point :593.1±60.0 °C(Predicted)
Density :1.49±0.1 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Sparingly), Methanol (Slightly)
form :Solid
pka :9.78±0.10(Predicted)
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P285 In case of inadequate ventilation wear respiratory protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P341 IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P310 Immediately call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P362 Take off contaminated clothing and wash before reuse.
P363 Wash contaminated clothing before reuse.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Cimicoxib is a non-steroidal anti-inflammatory drug (NSAID) that inhibits COX-2 selectively over COX-1 (IC50s = 0.005 and 3.3 μM, respectively). It inhibits paw swelling by 93% in a rat model of adjuvant-induced arthritis when administered at a dose of 1 mg/kg. Cimicoxib (3 mg/kg, p.o.) inhibits carrageenan-induced decreases in paw withdrawal latency in the hot plate test in a rat model of hyperalgesia. Formulations containing cimicoxib have been used in the treatment of pain and inflammation associated with osteoarthritis or surgery in dogs.

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