Canertinib dihydrochloride
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- $37 - $7103.25
- Product name: Canertinib dihydrochloride
- CAS: 289499-45-2
- MF: C24H27Cl3FN5O3
- MW: 558.86
- EINECS:
- MDL Number:MFCD09954112
- Synonyms:CANERTINIB DIHYDROCHLORIDE;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride;Canertinib.2HCL;CI-1033;N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride;Canertinib HCl;CI 103
38 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 5
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 25
- 1G
- 5G
- ManufacturerAK Scientific
- Product number3516AH
- Product descriptionCanertinibdihydrochloride
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3516AH
- Product descriptionCanertinibdihydrochloride
- Packaging10mg
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239262
- Product descriptionCanertinibdihydrochloride 98+%
- Packaging5mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239262
- Product descriptionCanertinibdihydrochloride 98+%
- Packaging10mg
- Price$51
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239262
- Product descriptionCanertinibdihydrochloride 98+%
- Packaging50mg
- Price$86
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239262
- Product descriptionCanertinibdihydrochloride 98+%
- Packaging100mg
- Price$111
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239262
- Product descriptionCanertinibdihydrochloride 98+%
- Packaging250mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000080
- Product descriptionCANERTINIB DIHYDROCHLORIDE 95.00%
- Packaging1G
- Price$2130.45
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000080
- Product descriptionCANERTINIB DIHYDROCHLORIDE 95.00%
- Packaging5G
- Price$7103.25
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3276
- Product descriptionCanertinibdihydrochloride
- Packaging100mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS490093
- Product descriptionCanertinibdihydrochloride ≥98%
- Packaging100mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS490093
- Product descriptionCanertinibdihydrochloride ≥98%
- Packaging250mg
- Price$187
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2204
- Product descriptionCanertinib Dihydrochloride
- Packaging25mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2204
- Product descriptionCanertinib Dihydrochloride
- Packaging100mg
- Price$129
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2204
- Product descriptionCanertinib Dihydrochloride
- Packaging1g
- Price$590
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb154663
- Product descriptionCanertinib dihydrochloride >98%
- Packaging100mg
- Price$414.8
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3516AH | Canertinibdihydrochloride | 5mg | $95 | 2021-12-16 | Buy |
| AK Scientific | 3516AH | Canertinibdihydrochloride | 10mg | $109 | 2021-12-16 | Buy |
| Ambeed | A239262 | Canertinibdihydrochloride 98+% | 5mg | $40 | 2021-12-16 | Buy |
| Ambeed | A239262 | Canertinibdihydrochloride 98+% | 10mg | $51 | 2021-12-16 | Buy |
| Ambeed | A239262 | Canertinibdihydrochloride 98+% | 50mg | $86 | 2021-12-16 | Buy |
| Ambeed | A239262 | Canertinibdihydrochloride 98+% | 100mg | $111 | 2021-12-16 | Buy |
| Ambeed | A239262 | Canertinibdihydrochloride 98+% | 250mg | $189 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000080 | CANERTINIB DIHYDROCHLORIDE 95.00% | 1G | $2130.45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000080 | CANERTINIB DIHYDROCHLORIDE 95.00% | 5G | $7103.25 | 2021-12-16 | Buy |
| ApexBio Technology | A3276 | Canertinibdihydrochloride | 100mg | $120 | 2021-12-16 | Buy |
| Arctom | AS490093 | Canertinibdihydrochloride ≥98% | 100mg | $110 | 2021-12-16 | Buy |
| Arctom | AS490093 | Canertinibdihydrochloride ≥98% | 250mg | $187 | 2021-12-16 | Buy |
| AvaChem | 2204 | Canertinib Dihydrochloride | 25mg | $45 | 2021-12-16 | Buy |
| AvaChem | 2204 | Canertinib Dihydrochloride | 100mg | $129 | 2021-12-16 | Buy |
| AvaChem | 2204 | Canertinib Dihydrochloride | 1g | $590 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb154663 | Canertinib dihydrochloride >98% | 100mg | $414.8 | 2021-12-16 | Buy |
Properties
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: >10mg/mL
form :solid
color :Light yellow to green yellow
solubility :DMSO: >10mg/mL
form :solid
color :Light yellow to green yellow
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
The HER family of receptor tyrosine kinases, EGFR, HER2, HER3, and HER4, mediate proliferation, migration, adhesion, differentiation, and survival in many different cell types and have been implicated in the development and progression of a variety of human tumors. Canertinib is an irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively. As a broadly applicable anti-cancer agent, it has been used to suppress proliferation of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), to inhibit growth and induce dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and to reduce proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM). Canertinib also displays anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein.More related product prices
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