2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurinetrihydrochloride
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- $57 - $1474.7
- Product name: 2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurinetrihydrochloride
- CAS: 294646-77-8
- MF: C24H29N7O
- MW: 431.53
- EINECS:
- MDL Number:MFCD18785641
- Synonyms:(R)-CR8;2-(R)-(1-Ethyl-2-hydroxyethylamino)-6-(4-(2-pyridyl)benzyl)-9-isopropylpurinetrihydrochloride;1-Butanol,2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]Methyl]aMino]-9H-purin-2-yl]aMino]-,(2R)-;(S)-CR8;(2R)-2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol;R8;CR8, (R)-Isomer ;(2R)-2-[[9-(1-Methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-butanol-1
14 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- Axon Medchem
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10
- 1mg
- 5mg
- 10mg
- 25MG
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0039-M005
- Product description(R)-CR8 ≥98%(NMR)
- Packaging5mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3878BB
- Product description(2R)-2-({9-(1-Methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol
- Packaging10mg
- Price$403
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBRS0000851
- Product description(R)-CR8 95.00%
- Packaging5MG
- Price$815.02
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberBRS0000851
- Product description(R)-CR8 95.00%
- Packaging25MG
- Price$1474.7
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon3228
- Product descriptionCDKinhibitorCR8-(R)-CR8 99%
- Packaging25mg
- Price$506
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14006
- Product description(R)-CR8 ≥98%
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14006
- Product description(R)-CR8
- Packaging5mg
- Price$179
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14006
- Product description(R)-CR8 ≥98%
- Packaging10mg
- Price$275
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0007451
- Product description(R)-CR8 >98.0%
- Packaging5mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0007451
- Product description(R)-CR8 >98.0%
- Packaging10mg
- Price$990
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberC3249
- Product descriptionCR8 ≥95% (HPLC)
- Packaging5mg
- Price$131.2
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberC3249
- Product descriptionCR8 ≥95% (HPLC)
- Packaging25mg
- Price$524
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number3605
- Product description(R)-CR8 ≥99%(HPLC)
- Packaging10
- Price$267
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberC790003
- Product descriptionCR8,(R)-Isomer
- Packaging10mg
- Price$250
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-0039-M005 | (R)-CR8 ≥98%(NMR) | 5mg | $180 | 2021-12-16 | Buy |
| AK Scientific | 3878BB | (2R)-2-({9-(1-Methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol | 10mg | $403 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000851 | (R)-CR8 95.00% | 5MG | $815.02 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000851 | (R)-CR8 95.00% | 25MG | $1474.7 | 2021-12-16 | Buy |
| Axon Medchem | Axon3228 | CDKinhibitorCR8-(R)-CR8 99% | 25mg | $506 | 2021-12-16 | Buy |
| Cayman Chemical | 14006 | (R)-CR8 ≥98% | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 14006 | (R)-CR8 | 5mg | $179 | 2024-03-01 | Buy |
| Cayman Chemical | 14006 | (R)-CR8 ≥98% | 10mg | $275 | 2024-03-01 | Buy |
| ChemScene | CS-0007451 | (R)-CR8 >98.0% | 5mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0007451 | (R)-CR8 >98.0% | 10mg | $990 | 2021-12-16 | Buy |
| Sigma-Aldrich | C3249 | CR8 ≥95% (HPLC) | 5mg | $131.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | C3249 | CR8 ≥95% (HPLC) | 25mg | $524 | 2024-03-01 | Buy |
| Tocris | 3605 | (R)-CR8 ≥99%(HPLC) | 10 | $267 | 2021-12-16 | Buy |
| TRC | C790003 | CR8,(R)-Isomer | 10mg | $250 | 2021-12-16 | Buy |
Properties
Melting point :98-100℃
Boiling point :671.4±65.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
pka :14.56±0.10(Predicted)
form :powder
color :off-white
Stability :Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Boiling point :671.4±65.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
pka :14.56±0.10(Predicted)
form :powder
color :off-white
Stability :Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Safety Information
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Description
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-CR8 is a second-generation analog of (R)-roscovitine that inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T with IC50 values of 0.09, 0.072, 0.041, 0.11, and 0.18 μM, respectively. (R)-CR8 has 2- to 4-fold improved potency for the inhibition of CDKs over (R)-roscovitine and can inhibit the proliferation of various cancer cell lines with ~40-fold more potency than (R)-roscovitine (IC50s ~ 0.39 versus 27.8 μM, respectively). (R)-CR8 also inhibits casein kinase 1 (CK1δ/ε) with an IC50 value of 0.40 μM and inhibits GSK3α/β with an IC50 value of 12 μM.More related product prices
2-Bromopropane 2-Chloropropane 3-Methyl-2-butanone CUMENE Volasertib (BI 6727) Fruquintinib|HMPL-013 METHOPRENE ACID 860352-01-8Related product price
- 2-Bromopropane
$10-1071 - 2-Chloropropane
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$22-974.55
Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
Career Henan Chemica Co
3B Pharmachem (Wuhan) International Co.,Ltd.
Bide Pharmatech Ltd.
Sigma-Aldrich
Shanghaizehan biopharma technology co., Ltd.
EMMX Biotechnology LLC
Shanghai EFE Biological Technology Co., Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.