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ChemicalBook >> CAS DataBase List >> HPI-4,Hedgehog Pathway Inhibitor 4

HPI-4,Hedgehog Pathway Inhibitor 4

HPI-4,Hedgehog Pathway Inhibitor 4 price.
  • $51 - $1800
  • Product name: HPI-4,Hedgehog Pathway Inhibitor 4
  • CAS: 302803-72-1
  • MF: C17H9Cl2N3O2
  • MW: 358.18
  • EINECS:687-330-4
  • MDL Number:MFCD01911757
  • Synonyms:HPI-4;HPI-4,Hedgehog Pathway Inhibitor 4;Ciliobrevin A;Ciliobrevin A(HPI4);2,4-Dichloro-a-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-benzenepropanenitrile;Hedgehog Pathway Inhibitor 4;2-(7-Chloro-4-oxo-3,4-dihydro-1H-quinazolin-2-ylidene)-3-(2,4-dichloro-phenyl)-3-oxo-propionitrile;(Z)-3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)propanenitrile
Price30 Properties Safety Information Description
30 prices
Selected condition：
Brand
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 25
  • 5mg
  • 5
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAmbeed
  • Product numberA766712
  • Product descriptionCiliobrevinA 98+%
  • Packaging5mg
  • Price$51
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA766712
  • Product descriptionCiliobrevinA 98+%
  • Packaging10mg
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA766712
  • Product descriptionCiliobrevinA 98+%
  • Packaging25mg
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA766712
  • Product descriptionCiliobrevinA 98+%
  • Packaging50mg
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000848
  • Product descriptionHPI-4 95.00%
  • Packaging25MG
  • Price$928.97
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8655
  • Product descriptionCiliobrevinA
  • Packaging5mg
  • Price$91
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8655
  • Product descriptionCiliobrevinA
  • Packaging10mg
  • Price$122
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8655
  • Product descriptionCiliobrevinA
  • Packaging25mg
  • Price$268
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8655
  • Product descriptionCiliobrevinA
  • Packaging50mg
  • Price$488
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22587
  • Product descriptionCiliobrevin A ≥98%
  • Packaging5mg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22587
  • Product descriptionCiliobrevin A ≥98%
  • Packaging10mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22587
  • Product descriptionCiliobrevin A ≥98%
  • Packaging25mg
  • Price$252
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22587
  • Product descriptionCiliobrevin A ≥98%
  • Packaging50mg
  • Price$469
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6016
  • Product descriptionCiliobrevinA 98.72%
  • Packaging5mg
  • Price$72
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6016
  • Product descriptionCiliobrevinA 98.72%
  • Packaging10mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6016
  • Product descriptionCiliobrevinA 98.72%
  • Packaging25mg
  • Price$216
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A766712 CiliobrevinA 98+% 5mg $51 2021-12-16 Buy
Ambeed A766712 CiliobrevinA 98+% 10mg $67 2021-12-16 Buy
Ambeed A766712 CiliobrevinA 98+% 25mg $88 2021-12-16 Buy
Ambeed A766712 CiliobrevinA 98+% 50mg $115 2021-12-16 Buy
American Custom Chemicals Corporation INB0000848 HPI-4 95.00% 25MG $928.97 2021-12-16 Buy
ApexBio Technology A8655 CiliobrevinA 5mg $91 2021-12-16 Buy
ApexBio Technology A8655 CiliobrevinA 10mg $122 2021-12-16 Buy
ApexBio Technology A8655 CiliobrevinA 25mg $268 2021-12-16 Buy
ApexBio Technology A8655 CiliobrevinA 50mg $488 2021-12-16 Buy
Cayman Chemical 22587 Ciliobrevin A ≥98% 5mg $68 2024-03-01 Buy
Cayman Chemical 22587 Ciliobrevin A ≥98% 10mg $109 2024-03-01 Buy
Cayman Chemical 22587 Ciliobrevin A ≥98% 25mg $252 2024-03-01 Buy
Cayman Chemical 22587 Ciliobrevin A ≥98% 50mg $469 2024-03-01 Buy
ChemScene CS-6016 CiliobrevinA 98.72% 5mg $72 2021-12-16 Buy
ChemScene CS-6016 CiliobrevinA 98.72% 10mg $96 2021-12-16 Buy
ChemScene CS-6016 CiliobrevinA 98.72% 25mg $216 2021-12-16 Buy
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Properties

Boiling point :564.5±50.0 °C(Predicted)
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :6.46±0.20(Predicted)
form :powder
color :off-white, off-white to orange

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

Ciliobrevin A is a hedgehog pathway inhibitor that blocks sonic hedgehog (Shh)-induced hedgehog pathway activation (IC50 = 7 μM). It disrupts primary cilia formation and inhibits the dynein-dependent microtubial gliding and ATPase activities of the cytoplasmic ATPases associated with various cellular activities (AAA+) family. Ciliobrevin A also inhibits mammalian target of rapamycin complex 1 (mTORC1) activity in uninfected and human cytomegalovirus (HCMV)-infected cells, suggesting that mTORC1 activation requires dynein-dependent transport for cellular activation.

Suppliers and manufacturers

career henan chemical co
HPI-4,Hedgehog Pathway Inhibitor 4
$1.00 /1g
HPI-4,Hedgehog Pathway Inhibitor 4 CAS:302803-72-1
ATK CHEMICAL COMPANY LIMITED
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
LEAP CHEM CO., LTD.
Hangzhou MolCore BioPharmatech Co.,Ltd.
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.