2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
![2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride price.](/CAS2/GIF/324523-20-8.gif)
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- $36 - $2245.7
- Product name: 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
- CAS: 324523-20-8
- MF: C24H26Cl2N2O2
- MW: 445.38
- EINECS:
- MDL Number:MFCD16038896
- Synonyms:2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride;NPS-2143 HCL;NPS-2143 (Mono HCl);2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1);SB-262470-A hydrochloride;NPS2143 hydrochloride, >=98%;NPS-2143 hydrochloride (SB-262470A);NPS2143;NPS 2143 HCL
28 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1MG
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 200mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number3936AH
- Product descriptionNPS2143 hydrochloride
- Packaging100mg
- Price$815
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA464000
- Product descriptionNPS2143 hydrochloride 98+%
- Packaging5mg
- Price$73
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001374
- Product descriptionNPS 2143 HYDROCHLORIDE 95.00%
- Packaging5MG
- Price$495.46
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001374
- Product descriptionNPS 2143 HYDROCHLORIDE 95.00%
- Packaging1MG
- Price$148.05
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3667
- Product descriptionNPS2143 hydrochloride
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3667
- Product descriptionNPS2143 hydrochloride
- Packaging10mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3667
- Product descriptionNPS2143 hydrochloride
- Packaging50mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3667
- Product descriptionNPS2143 hydrochloride
- Packaging200mg
- Price$930
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146174
- Product descriptionNPS-2143 HCL >99%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146174
- Product descriptionNPS-2143 HCL >99%
- Packaging250mg
- Price$1133.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146174
- Product descriptionNPS-2143 HCL >99%
- Packaging1g
- Price$2245.7
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17903
- Product descriptionNPS 2143 (hydrochloride) ≥98%
- Packaging1mg
- Price$48
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17903
- Product descriptionNPS 2143 (hydrochloride) ≥98%
- Packaging5mg
- Price$117
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17903
- Product descriptionNPS 2143 (hydrochloride) ≥98%
- Packaging10mg
- Price$163
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17903
- Product descriptionNPS 2143 (hydrochloride) ≥98%
- Packaging25mg
- Price$347
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM141433
- Product description(R)-2-chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrilehydrochloride 98%
- Packaging50mg
- Price$219
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3936AH | NPS2143 hydrochloride | 100mg | $815 | 2021-12-16 | Buy |
| Ambeed | A464000 | NPS2143 hydrochloride 98+% | 5mg | $73 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001374 | NPS 2143 HYDROCHLORIDE 95.00% | 5MG | $495.46 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001374 | NPS 2143 HYDROCHLORIDE 95.00% | 1MG | $148.05 | 2021-12-16 | Buy |
| ApexBio Technology | A3667 | NPS2143 hydrochloride | 5mg | $60 | 2021-12-16 | Buy |
| ApexBio Technology | A3667 | NPS2143 hydrochloride | 10mg | $85 | 2021-12-16 | Buy |
| ApexBio Technology | A3667 | NPS2143 hydrochloride | 50mg | $320 | 2021-12-16 | Buy |
| ApexBio Technology | A3667 | NPS2143 hydrochloride | 200mg | $930 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146174 | NPS-2143 HCL >99% | 100mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146174 | NPS-2143 HCL >99% | 250mg | $1133.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146174 | NPS-2143 HCL >99% | 1g | $2245.7 | 2021-12-16 | Buy |
| Cayman Chemical | 17903 | NPS 2143 (hydrochloride) ≥98% | 1mg | $48 | 2024-03-01 | Buy |
| Cayman Chemical | 17903 | NPS 2143 (hydrochloride) ≥98% | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 17903 | NPS 2143 (hydrochloride) ≥98% | 10mg | $163 | 2024-03-01 | Buy |
| Cayman Chemical | 17903 | NPS 2143 (hydrochloride) ≥98% | 25mg | $347 | 2024-03-01 | Buy |
| Chemenu | CM141433 | (R)-2-chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrilehydrochloride 98% | 50mg | $219 | 2021-12-16 | Buy |
Properties
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :powder
color :white to beige
optical activity :[α]20/D +20 to +24°, c = 1.0 in methanol
solubility :DMSO: >10mg/mL
form :powder
color :white to beige
optical activity :[α]20/D +20 to +24°, c = 1.0 in methanol
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis. Activation of CaSR on parathyroid cells decreases the secretion of parathyroid hormone (PTH), which in turn reduces blood calcium concentration. NPS 2143 is a potent and selective antagonist of CaSR (IC50 = 43 nM) that stimulates PTH secretion from parathyroid cells in vitro (EC50 = 39 nM). It is effective in vivo, causing a sustained increase in plasma PTH in rats when given intravenously. Daily oral administration of NPS 2143 to osteopenic ovariectomized rats results in a dramatic increase in bone turnover, as well as increased circulating PTH levels.Related product price
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