N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea
![N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea price.](/CAS/GIF/330796-24-2.gif)
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- $73 - $1593.9
- Product name: N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea
- CAS: 330796-24-2
- MF: C23H15ClF4N4O2
- MW: 490.84
- EINECS:
- MDL Number:MFCD10567691
- Synonyms:N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea;1-(4-chloro-3-trifluoroMethyl-phenyl)-3-[3-(4-fluoro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylMethyl]-urea;1-[4-chloro-3-(trifluoromethyl)phenyl]-3-[[3-(4-fluorophenyl)-4-oxo-quinazolin-2-yl]methyl]urea;Hedgehog Antagonist VIII;N-[4-Chloro-3-(trifluoromethyl)phenyl]-N’-[[3-(4-fluorophenyl)-3,4-dihydro\n-4-oxo-2-quinazolinyl]methyl]urea;Hedgehog Antagonist VII;Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]-
10 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Biosynth Carbosynth
- Cayman Chemical
- TRC
Package
- 500μg
- 1MG
- 2mg
- 5mg
- 10MG
- ManufacturerAK Scientific
- Product number4179CR
- Product description1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[[3-(4-fluorophenyl)-4-oxoquinazolin-2-yl]methyl]urea
- Packaging5mg
- Price$338
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0014283
- Product descriptionN-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-N'-[[3-(4-FLUOROPHENYL)-3,4-DIHYDRO-4-OXO-2-QUINAZOLINYL]METHYL]UREA 95.00%
- Packaging1MG
- Price$704.55
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0014283
- Product descriptionN-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-N'-[[3-(4-FLUOROPHENYL)-3,4-DIHYDRO-4-OXO-2-QUINAZOLINYL]METHYL]UREA 95.00%
- Packaging10MG
- Price$1593.9
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC20050
- Product descriptionN-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea
- Packaging1mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC20050
- Product descriptionN-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea
- Packaging2mg
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16097
- Product descriptionHedgehog Antagonist VIII ≥98%
- Packaging500μg
- Price$73
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16097
- Product descriptionHedgehog Antagonist VIII ≥98%
- Packaging1mg
- Price$121
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16097
- Product descriptionHedgehog Antagonist VIII ≥98%
- Packaging5mg
- Price$217
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16097
- Product descriptionHedgehog Antagonist VIII ≥98%
- Packaging10mg
- Price$359
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberC421960
- Product descriptionN-[4-Chloro-3-(trifluoromethyl)phenyl]-N’-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea
- Packaging10mg
- Price$255
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4179CR | 1-[4-Chloro-3-(trifluoromethyl)phenyl]-3-[[3-(4-fluorophenyl)-4-oxoquinazolin-2-yl]methyl]urea | 5mg | $338 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0014283 | N-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-N'-[[3-(4-FLUOROPHENYL)-3,4-DIHYDRO-4-OXO-2-QUINAZOLINYL]METHYL]UREA 95.00% | 1MG | $704.55 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0014283 | N-[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]-N'-[[3-(4-FLUOROPHENYL)-3,4-DIHYDRO-4-OXO-2-QUINAZOLINYL]METHYL]UREA 95.00% | 10MG | $1593.9 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC20050 | N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea | 1mg | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC20050 | N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea | 2mg | $350 | 2021-12-16 | Buy |
| Cayman Chemical | 16097 | Hedgehog Antagonist VIII ≥98% | 500μg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 16097 | Hedgehog Antagonist VIII ≥98% | 1mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 16097 | Hedgehog Antagonist VIII ≥98% | 5mg | $217 | 2024-03-01 | Buy |
| Cayman Chemical | 16097 | Hedgehog Antagonist VIII ≥98% | 10mg | $359 | 2024-03-01 | Buy |
| TRC | C421960 | N-[4-Chloro-3-(trifluoromethyl)phenyl]-N’-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]urea | 10mg | $255 | 2021-12-16 | Buy |
Properties
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml
form :A crystalline solid
pka :12.17±0.46(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.3 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml
form :A crystalline solid
pka :12.17±0.46(Predicted)
Safety Information
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Description
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.Suppliers and manufacturers
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