20-ETHYL PROSTAGLANDIN F2ALPHA
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- $64 - $650
- Product name: 20-ETHYL PROSTAGLANDIN F2ALPHA
- CAS: 36950-85-3
- MF: C22H38O5
- MW: 382.53
- EINECS:
- MDL Number:MFCD01723651
- Synonyms:9ALPHA,11ALPHA,15S-TRIHYDROXY-20A,20B-DIHOMOPROSTA-5Z,13E-DIEN-1-OIC ACID;20-ethyl-pgf2-alpha ;2-beta(1e,3s*),3-alpha,5-alpha))--alpha(z ;7-(3,5-dihydroxy-2-(3-hydroxy-1-decenyl)cyclopentyl)-5-heptenoicaci(1r-(1 ;racemic-ici74205 ;(Z)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,S)-3-hydroxy-1-decenyl]cyclopentan-1α-yl]-5-heptenoic acid;20-Ethylprostaglandin F2α;ICI 74205
4 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
Package
- 1mg
- 5mg
- 10mg
- ManufacturerAK Scientific
- Product number1343AH
- Product description20-EthylprostaglandinF2alpha
- Packaging10mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16940
- Product description20-ethyl Prostaglandin F2α ≥98%
- Packaging1mg
- Price$64
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16940
- Product description20-ethyl Prostaglandin F2α ≥98%
- Packaging5mg
- Price$280
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16940
- Product description20-ethyl Prostaglandin F2α ≥98%
- Packaging10mg
- Price$497
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1343AH | 20-EthylprostaglandinF2alpha | 10mg | $650 | 2021-12-16 | Buy |
| Cayman Chemical | 16940 | 20-ethyl Prostaglandin F2α ≥98% | 1mg | $64 | 2024-03-01 | Buy |
| Cayman Chemical | 16940 | 20-ethyl Prostaglandin F2α ≥98% | 5mg | $280 | 2024-03-01 | Buy |
| Cayman Chemical | 16940 | 20-ethyl Prostaglandin F2α ≥98% | 10mg | $497 | 2024-03-01 | Buy |
Properties
Boiling point :429.67°C (rough estimate)
Density :1.0323 (rough estimate)
refractive index :1.6120 (estimate)
solubility :DMF: 33 mg/ml; DMSO: 14 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 3 mg/ml
pka :4.76±0.10(Predicted)
Density :1.0323 (rough estimate)
refractive index :1.6120 (estimate)
solubility :DMF: 33 mg/ml; DMSO: 14 mg/ml; Ethanol: 33 mg/ml; PBS (pH 7.2): 3 mg/ml
pka :4.76±0.10(Predicted)
Safety Information
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Description
20-ethyl Prostaglandin F2α (20-ethyl PGF2α) is an analog of PGF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms. It is therefore a modified version of the clinically approved glaucoma medication unoprostone. Unoprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGF2α retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency as an intraocular hypotensive agent compared to unoprostone. The 2 carbon extension in 20-ethyl-PGF2α increases the Ki (120 nM) for the FP receptor from bovine corpus luteum only about 2.5-fold compared to PGF2α (50 nM). In vivo effects may be prolonged using 20-ethyl PGF2α, as the activity of 15-hydroxy PGDH using 20-ethyl PGF2α as a substrate is only 35% of the activity observed with PGF2α.More related product prices
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