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ChemicalBook >> CAS DataBase List >> 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide

2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide

2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide price.
  • $37 - $4810
  • Product name: 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
  • CAS: 383432-38-0
  • MF: C27H27N5O3
  • MW: 469.54
  • EINECS:
  • MDL Number:MFCD15144738
  • Synonyms:2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide;2-Methoxy-N-[(2E)-3-[4-[[3-Methyl-4-[(6-Methyl-3-pyridinyl)oxy]phenyl]aMino]-6-quinazolinyl]-2-prope;CP-724714 (E-Double bond);CP-724714(E)-2-methoxy-N-(3-(4-(3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino)quinazolin-6-yl)allyl)acetamide;(E)-2-Methoxy-N-(3-(4-(3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino)quinazolin-6-yl)allyl)a;714;CP 724;CP724
Price23 Properties Safety Information Description
23 prices
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Brand
  • Adipogen Life Sciences
  • AK Scientific
  • American Custom Chemicals Corporation
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • 5g
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1033-M100
  • Product descriptionCP-724714 ≥95%
  • Packaging100mg
  • Price$1247
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1033
  • Product descriptionCP-724714
  • Packaging1mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2337AH
  • Product description2-Methoxy-N-[(2e)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
  • Packaging10mg
  • Price$261
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2337AH
  • Product description2-Methoxy-N-[(2e)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
  • Packaging100mg
  • Price$980
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000086
  • Product descriptionCP-724714 95.00%
  • Packaging5MG
  • Price$940.17
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBC165637
  • Product descriptionCP 724714 NEW
  • Packaging10mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBC165637
  • Product descriptionCP 724714 NEW
  • Packaging50mg
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19172
  • Product descriptionCP 724,714 ≥95%
  • Packaging1mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19172
  • Product descriptionCP 724,714 ≥95%
  • Packaging5mg
  • Price$142
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19172
  • Product descriptionCP 724,714 ≥95%
  • Packaging10mg
  • Price$266
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19172
  • Product descriptionCP 724,714 ≥95%
  • Packaging25mg
  • Price$530
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0262
  • Product descriptionCP-724714 99.33%
  • Packaging5mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0262
  • Product descriptionCP-724714 99.33%
  • Packaging10mg
  • Price$194
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0262
  • Product descriptionCP-724714 99.33%
  • Packaging50mg
  • Price$576
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0262
  • Product descriptionCP-724714 99.33%
  • Packaging100mg
  • Price$858
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31002026
  • Product descriptionCP-724714 98+%
  • Packaging50mg
  • Price$492
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1033-M100 CP-724714 ≥95% 100mg $1247 2021-12-16 Buy
AK Scientific SYN1033 CP-724714 1mg $100 2021-12-16 Buy
AK Scientific 2337AH 2-Methoxy-N-[(2e)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide 10mg $261 2021-12-16 Buy
AK Scientific 2337AH 2-Methoxy-N-[(2e)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide 100mg $980 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000086 CP-724714 95.00% 5MG $940.17 2021-12-16 Buy
Biosynth Carbosynth BC165637 CP 724714 NEW 10mg $140 2021-12-16 Buy
Biosynth Carbosynth BC165637 CP 724714 NEW 50mg $540 2021-12-16 Buy
Cayman Chemical 19172 CP 724,714 ≥95% 1mg $37 2024-03-01 Buy
Cayman Chemical 19172 CP 724,714 ≥95% 5mg $142 2024-03-01 Buy
Cayman Chemical 19172 CP 724,714 ≥95% 10mg $266 2024-03-01 Buy
Cayman Chemical 19172 CP 724,714 ≥95% 25mg $530 2024-03-01 Buy
ChemScene CS-0262 CP-724714 99.33% 5mg $108 2021-12-16 Buy
ChemScene CS-0262 CP-724714 99.33% 10mg $194 2021-12-16 Buy
ChemScene CS-0262 CP-724714 99.33% 50mg $576 2021-12-16 Buy
ChemScene CS-0262 CP-724714 99.33% 100mg $858 2021-12-16 Buy
Crysdot CD31002026 CP-724714 98+% 50mg $492 2021-12-16 Buy
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Properties

Boiling point :687.3±55.0 °C(Predicted)
Density :1.251
storage temp. :Store at -20°C
solubility :DMF: 3 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml; Ethanol: 2 mg/ml
form :A crystalline solid
pka :13.95±0.46(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

CP 724,714 is a selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM. It demonstrates greater than 640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, and c-Met. CP 724,714 has been shown to inhibit the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 with IC50 values of 0.25 and 0.95 μM, respectively. It also demonstrates antitumor activity in various human tumor xenograft models. However, CP 724,714 was discontinued from clinical development due to hepatotoxicity caused by its ability to inhibit hepatic efflux transporters at low micromolar concentrations.

Suppliers and manufacturers

Capot Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
TargetMol Chemicals Inc.
Aladdin Scientific
Amadis Chemical Company Limited Shanghai Boyle Chemical Co., Ltd. Chembest Research Laboratories Limited Shanghai Paulshine Chemical Co., Ltd. China Langchem Inc.