A-331440 L-TARTARIC ACID SALT

$193 - $702
Product name: A-331440 L-TARTARIC ACID SALT
CAS: 392338-13-5
MF: C22H27N3O
MW: 349.47
EINECS:
MDL Number:MFCD07363908
Synonyms:A-331440 L-TARTARIC ACID SALT;(R)-4'-(3-(3-(diMethylaMino)pyrrolidin-1-yl)propoxy)biphenyl-4-carbonitrile;A 331440;4′-[3-[3(R)-Dimethylamino-1-pyrrolidinyl]propoxy]-[1,1-biphenyl]-4′-carbonitrile L-tartrate hydrate;A-331440 L-tartrate hydrate;4-[4-[3-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]propoxy]phenyl]benzonitrile;A331440 free base;[1,1'-Biphenyl]-4-carbonitrile, 4'-[3-[(3R)-3-(dimethylamino)-1-pyrrolidinyl]propoxy]-

Price6 Properties Safety Information Description

6 prices

Selected condition：

Brand

American Custom Chemicals Corporation
Sigma-Aldrich
Tocris
Usbiological

Package

50
5MG
10mg
25mg

ManufacturerAmerican Custom Chemicals Corporation
Product numberAPI0013745
Product descriptionA-331440 95.00%
Packaging5MG
Price$498.98
Updated2021-12-16
Buy

ManufacturerSigma-Aldrich
Product numberA3104
Product descriptionA-331440 L-tartrate hydrate ≥98% (HPLC), solid
Packaging25mg
Price$604
Updated2024-03-01
Buy

ManufacturerSigma-Aldrich
Product numberA7730
Product descriptionA-331440 dihydrochloride ≥98% (HPLC), solid
Packaging25mg
Price$564
Updated2024-03-01
Buy

ManufacturerSigma-Aldrich
Product numberA7730
Product descriptionA-331440 dihydrochloride ≥98% (HPLC), solid
Packaging5mg
Price$193
Updated2024-03-01
Buy

ManufacturerTocris
Product number4697
Product descriptionA-331440 dihydrochloride ≥98%(HPLC)
Packaging50
Price$702
Updated2021-12-16
Buy

ManufacturerUsbiological
Product number254466
Product descriptionA 331440 dihydrochloride
Packaging10mg
Price$480
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0013745	A-331440 95.00%	5MG	$498.98	2021-12-16	Buy
Sigma-Aldrich	A3104	A-331440 L-tartrate hydrate ≥98% (HPLC), solid	25mg	$604	2024-03-01	Buy
Sigma-Aldrich	A7730	A-331440 dihydrochloride ≥98% (HPLC), solid	25mg	$564	2024-03-01	Buy
Sigma-Aldrich	A7730	A-331440 dihydrochloride ≥98% (HPLC), solid	5mg	$193	2024-03-01	Buy
Tocris	4697	A-331440 dihydrochloride ≥98%(HPLC)	50	$702	2021-12-16	Buy
Usbiological	254466	A 331440 dihydrochloride	10mg	$480	2021-12-16	Buy

Properties

storage temp. :2-8°C
solubility :H₂O: insoluble
form :solid
color :white to off-white

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning		P264, P280, P305+P351+P338,P337+P313P

Precautionary statements:

P305+P351+P338

IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

A non-imidazole H3 histamine receptor antagonist. Presynaptic histamine H3 receptors regulate the release of histamine and other neurotransmitters, and histamine H3 receptor antagonists enhance neurotransmitter release. A-331440 is a histamine H3 receptor antagonist, which binds strongly and selectively to both human and rat histamine H(3) receptors (K(i)=25 nM). Mice on a high-fat diet (45 kcal % lard) prior to 28-day oral b.i.d. dosing for measurement of obesity-related parameters. A-331440 administered at 0.5 mg/kg had no significant effect on weight, whereas 5 mg/kg decreased weight comparably to dexfenfluramine (10 mg/kg). A-331440 administered at 15 mg/kg reduced weight to a level comparable to mice on the low-fat diet. The two higher doses reduced body fat and the highest dose also normalized an insulin tolerance test. Both data shows that the histamine H3 receptor antagonist, A-331440, has potential as an antiobesity agent.

Suppliers and manufacturers

TargetMol Chemicals Inc. TargetMol Chemicals Inc.

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