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ChemicalBook >> CAS DataBase List >> 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole

3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole price.
  • $98 - $13415
  • Product name: 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole
  • CAS: 395104-30-0
  • MF: C22H24N6O
  • MW: 388.47
  • EINECS:200-528-9
  • MDL Number:MFCD16038646
  • Synonyms:3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole;CC-401;CC-401 (HCl);3-(3-(2-(piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-3-yl)-1H-indazole;CC4013-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1H-1,2,4-triazol-5-yl)-1H-indazole;CC-401, >=98%;3-(3-(2-(Piperidin-1-yl)ethoxy)phenyl)-5-(1H-1,2,4-triazol-5-yl)-1H-indazole;1-[5-(1H-1,2,4-Triazol-5-yl)-1H-indazol-3-yl]-3-(2-piperidinoethoxy)benzene
24 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • Matrix Scientific
  • TRC
Package
  • 1mg
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1000mg
  • 1g
  • 5g
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product numberY0278
  • Product description3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1h-1,2,4-triazol-5-yl)-1H-indazole
  • Packaging5g
  • Price$13415
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000066
  • Product descriptionCC-401 95.00%
  • Packaging5MG
  • Price$335.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1260
  • Product descriptionCC-401
  • Packaging5mg
  • Price$139
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1260
  • Product descriptionCC-401
  • Packaging10mM(in 1mL DMSO)
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1260
  • Product descriptionCC-401
  • Packaging10mg
  • Price$251
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1260
  • Product descriptionCC-401
  • Packaging50mg
  • Price$744
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2025
  • Product descriptionCC-401 99%
  • Packaging5mg
  • Price$126.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2025
  • Product descriptionCC-401 99%
  • Packaging25mg
  • Price$511.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611609
  • Product descriptionCC-401
  • Packaging100mg
  • Price$690.2
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180953
  • Product descriptionCC-401 >98%
  • Packaging100mg
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611609
  • Product descriptionCC-401
  • Packaging250mg
  • Price$1356.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180953
  • Product descriptionCC-401 >98%
  • Packaging250mg
  • Price$1356.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb611609
  • Product descriptionCC-401
  • Packaging1g
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180953
  • Product descriptionCC-401 >98%
  • Packaging1000mg
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18867
  • Product descriptionCC-401 ≥98%
  • Packaging1mg
  • Price$106
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18867
  • Product descriptionCC-401 ≥98%
  • Packaging5mg
  • Price$467
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific Y0278 3-[3-[2-(1-Piperidinyl)ethoxy]phenyl]-5-(1h-1,2,4-triazol-5-yl)-1H-indazole 5g $13415 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000066 CC-401 95.00% 5MG $335.5 2021-12-16 Buy
ApexBio Technology B1260 CC-401 5mg $139 2021-12-16 Buy
ApexBio Technology B1260 CC-401 10mM(in 1mL DMSO) $150 2021-12-16 Buy
ApexBio Technology B1260 CC-401 10mg $251 2021-12-16 Buy
ApexBio Technology B1260 CC-401 50mg $744 2021-12-16 Buy
Axon Medchem Axon2025 CC-401 99% 5mg $126.5 2021-12-16 Buy
Axon Medchem Axon2025 CC-401 99% 25mg $511.5 2021-12-16 Buy
Biorbyt Ltd orb611609 CC-401 100mg $690.2 2021-12-16 Buy
Biorbyt Ltd orb180953 CC-401 >98% 100mg $765 2021-12-16 Buy
Biorbyt Ltd orb611609 CC-401 250mg $1356.6 2021-12-16 Buy
Biorbyt Ltd orb180953 CC-401 >98% 250mg $1356.6 2021-12-16 Buy
Biorbyt Ltd orb611609 CC-401 1g $2691.1 2021-12-16 Buy
Biorbyt Ltd orb180953 CC-401 >98% 1000mg $2691.1 2021-12-16 Buy
Cayman Chemical 18867 CC-401 ≥98% 1mg $106 2024-03-01 Buy
Cayman Chemical 18867 CC-401 ≥98% 5mg $467 2024-03-01 Buy

Properties

Boiling point :681.5±65.0 °C(Predicted)
Density :1.275
storage temp. :Store at -20°C
solubility :≥19.4 mg/mL in DMSO; ≥2.32 mg/mL in EtOH with ultrasonic; ≥8.7 mg/mL in H2O
form :solid
pka :9.44±0.20(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

c-Jun N-terminal kinases (JNKs) are MAP kinase family members that become highly activated after cells are exposed to stress conditions and are poorly activated by exposure to growth factors or mitogens. CC-401 is a potent inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM). It has at least 40-fold selectivity for JNK compared with other related kinases. CC-401 is bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model. It also has been shown to decrease hepatic necrosis and apoptosis after orthotopic liver transplantation and prevent acute renal failure following ischemia/reperfusion associated with renal transplantation in rats.

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