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ChemicalBook >> CAS DataBase List >> 7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole

7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole

7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole price.
  • $28 - $599
  • Product name: 7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole
  • CAS: 397290-30-1
  • MF: C23H17N3OS3
  • MW: 447.59558
  • EINECS:
  • MDL Number:MFCD04419018
  • Synonyms:7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole;Gue1654;Gue-1654 (Gue 1654;N-[7-(Methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenylbenzeneacetamide;Gue1654 >=98% (HPLC);Benzeneacetamide, N-[7-(methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenyl- (9CI)
Price10 Properties Safety Information Description
10 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 1mg
  • 2.5mg
  • 5mg
  • 10
  • 10mg
  • 25mg
  • ManufacturerAK Scientific
  • Product number5176CN
  • Product descriptionN-(2-Methylsulfanyl-[1,3]thiazolo[4,5-g][1,3]benzothiazol-7-yl)-2,2-diphenylacetamide
  • Packaging25mg
  • Price$479
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29686
  • Product descriptionGue1654
  • Packaging1mg
  • Price$28
  • Updated2022-04-27
  • Buy
  • ManufacturerCayman Chemical
  • Product number29686
  • Product descriptionGue1654
  • Packaging5mg
  • Price$82
  • Updated2022-04-27
  • Buy
  • ManufacturerCayman Chemical
  • Product number29686
  • Product descriptionGue1654
  • Packaging10mg
  • Price$136
  • Updated2022-04-27
  • Buy
  • ManufacturerCayman Chemical
  • Product number29686
  • Product descriptionGue1654
  • Packaging25mg
  • Price$305
  • Updated2022-04-27
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0434
  • Product descriptionGue1654 ≥98% (HPLC)
  • Packaging5mg
  • Price$85.8
  • Updated2022-05-15
  • Buy
  • ManufacturerTocris
  • Product number4742
  • Product descriptionGue1654 ≥97%(HPLC)
  • Packaging10
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number4742
  • Product descriptionGue1654 ≥97%(HPLC)
  • Packaging50
  • Price$599
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberG876508
  • Product descriptionGue1654
  • Packaging2.5mg
  • Price$165
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number255416
  • Product descriptionGue 1654
  • Packaging10mg
  • Price$389
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5176CN N-(2-Methylsulfanyl-[1,3]thiazolo[4,5-g][1,3]benzothiazol-7-yl)-2,2-diphenylacetamide 25mg $479 2021-12-16 Buy
Cayman Chemical 29686 Gue1654 1mg $28 2022-04-27 Buy
Cayman Chemical 29686 Gue1654 5mg $82 2022-04-27 Buy
Cayman Chemical 29686 Gue1654 10mg $136 2022-04-27 Buy
Cayman Chemical 29686 Gue1654 25mg $305 2022-04-27 Buy
Sigma-Aldrich SML0434 Gue1654 ≥98% (HPLC) 5mg $85.8 2022-05-15 Buy
Tocris 4742 Gue1654 ≥97%(HPLC) 10 $147 2021-12-16 Buy
Tocris 4742 Gue1654 ≥97%(HPLC) 50 $599 2021-12-16 Buy
TRC G876508 Gue1654 2.5mg $165 2021-12-16 Buy
Usbiological 255416 Gue 1654 10mg $389 2021-12-16 Buy

Properties

Density :1.44±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL (clear solution; warmed)
form :powder
pka :10.58±0.43(Predicted)
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Gue1654 is a Gβγ-signaling-biased 5-OxoETE receptor antagonist. It inhibits neutrophil and eosinophil shape change and chemotaxis induced by 5-OxoETE (Item No. 34250) but not chemoattractant C5a or prostaglandin D2 (PGD2; ). Gue1654 inhibits 5-OxoETE-induced Gβγ-mediated inositol monophosphate (IP1) production in HEK293 cells transiently expressing the 5-OxoETE receptor, an effect that can be blocked by the Gβγ-inhibitor gallein, but has no effect on IP1 production induced by stimulation of endogenous Gαq-linked muscarinic receptors. In a bioluminescence resonance energy transfer (BRET) assay, Gue1654 reduces the 5-OxoETE-induced, but not basal, BRET fluorescence response, indicating disruption of the interaction between ligand-activated 5-OxoETE receptor and Gβγ.

Suppliers and manufacturers

TargetMol Chemicals Inc.
Aladdin Scientific Guangzhou Isun Pharmaceutical Co., Ltd EMMX Biotechnology LLC BOC Sciences ChemeGen(Shanghai) Biotechnology Co.,Ltd. Energy Chemical MedBioPharmaceutical Technology Inc TargetMol Chemicals Inc. Nantong QuanYi Biotechnology Co., Ltd