3PO
|
- $37 - $800
- Product name: 3PO
- CAS: 18550-98-6
- MF: C13H10N2O
- MW: 210.23
- EINECS:
- MDL Number:MFCD00224002
- Synonyms:3PO (inhibitor of glucose metabolism);(E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone;3 PO;3-PO;2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)-;3PO >=98% (HPLC);inhibitor of glucose metabolism
13 prices
Selected condition：
Brand
- Axon Medchem
- Cayman Chemical
- Crysdot
- DC Chemicals
- Sigma-Aldrich
Package
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 2x50mg
- 250mg
- 1g
- ManufacturerAxon Medchem
- Product numberAxon2175
- Product description3PO 99%
- Packaging10mg
- Price$71.5
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2175
- Product description3PO 99%
- Packaging2x50mg
- Price$253
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19276
- Product description3PO ≥98%
- Packaging25mg
- Price$116
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19276
- Product description3PO ≥98%
- Packaging10mg
- Price$54
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19276
- Product description3PO ≥98%
- Packaging5mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD31002880
- Product description(E)-3PO 98+%
- Packaging5mg
- Price$42
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002880
- Product description(E)-3PO 98+%
- Packaging10mg
- Price$63
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002880
- Product description(E)-3PO 98+%
- Packaging50mg
- Price$189
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002880
- Product description(E)-3PO 98+%
- Packaging100mg
- Price$340
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10452
- Product description3PO >98%
- Packaging250mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10452
- Product description3PO >98%
- Packaging1g
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1343
- Product description3PO ≥98% (HPLC)
- Packaging5MG
- Price$74.6
- Updated2023-06-20
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML1343
- Product description3PO ≥98% (HPLC)
- Packaging25MG
- Price$287
- Updated2023-06-20
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Axon Medchem | Axon2175 | 3PO 99% | 10mg | $71.5 | 2021-12-16 | Buy |
| Axon Medchem | Axon2175 | 3PO 99% | 2x50mg | $253 | 2021-12-16 | Buy |
| Cayman Chemical | 19276 | 3PO ≥98% | 25mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 19276 | 3PO ≥98% | 10mg | $54 | 2024-03-01 | Buy |
| Cayman Chemical | 19276 | 3PO ≥98% | 5mg | $37 | 2024-03-01 | Buy |
| Crysdot | CD31002880 | (E)-3PO 98+% | 5mg | $42 | 2021-12-16 | Buy |
| Crysdot | CD31002880 | (E)-3PO 98+% | 10mg | $63 | 2021-12-16 | Buy |
| Crysdot | CD31002880 | (E)-3PO 98+% | 50mg | $189 | 2021-12-16 | Buy |
| Crysdot | CD31002880 | (E)-3PO 98+% | 100mg | $340 | 2021-12-16 | Buy |
| DC Chemicals | DC10452 | 3PO >98% | 250mg | $400 | 2021-12-16 | Buy |
| DC Chemicals | DC10452 | 3PO >98% | 1g | $800 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML1343 | 3PO ≥98% (HPLC) | 5MG | $74.6 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1343 | 3PO ≥98% (HPLC) | 25MG | $287 | 2023-06-20 | Buy |
Properties
Boiling point :387.8±42.0 °C(Predicted)
Density :1.192±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 5 mg/ml)
pka :3.49±0.11(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Density :1.192±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 5 mg/ml)
pka :3.49±0.11(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
3PO is a competitive inhibitor of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase 3 (PFKFB3; IC50 = 23 μM) that causes a rapid reduction in fructose 2,6-bisphosphate (F2,6BP), glucose uptake, and lactate secretion. This is followed by a reduction in the steady-state concentration of ATP and NADH, resulting in cell cycle arrest in Jurkat T cell leukemia cells. 3PO is selectively cytostatic to ras-transformed bronchial epithelial cells relative to normal bronchial epithelial cells. 3PO markedly reduces intracellular F2,6BP, glucose uptake, and growth of established tumors in mice. It also blocks angiogenesis, reducing vessel sprouting in endothelial cell spheroids, zebrafish embryos, and the postnatal mouse retina by inhibiting endothelial cell proliferation and migration.Related product price
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Suppliers and manufacturers
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Shanghai Acmec Biochemical Technology Co., Ltd.
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific
