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ChemicalBook >> CAS DataBase List >> N-(6-CHLORO-9H-PYRIDO[3,4-B]INDOL-8-YL)-3-PYRIDINECARBOXAMIDE DIHYDROCHLORIDE

N-(6-CHLORO-9H-PYRIDO[3,4-B]INDOL-8-YL)-3-PYRIDINECARBOXAMIDE DIHYDROCHLORIDE

N-(6-CHLORO-9H-PYRIDO[3,4-B]INDOL-8-YL)-3-PYRIDINECARBOXAMIDE DIHYDROCHLORIDE price.
  • $32 - $1800
  • Product name: N-(6-CHLORO-9H-PYRIDO[3,4-B]INDOL-8-YL)-3-PYRIDINECARBOXAMIDE DIHYDROCHLORIDE
  • CAS: 431898-65-6
  • MF: C17H11ClN4O
  • MW: 322.75
  • EINECS:
  • MDL Number:MFCD18089825
  • Synonyms:N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)pyridine-3-carboxamide;IKK Inhibitor X;PS 1145;N-(6-CHLORO-9H-PYRIDO[3,4-B]INDOL-8-YL)-3-PYRIDINECARBOXAMIDE DIHYDROCHLORIDE;PS-1145 DIHYDROCHLORIDE;PS 1145;PS1145;CS-2600;3-Pyridinecarboxamide, N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-
22 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 500μg
  • 10
  • 10mg
  • 2x5mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number4450CR
  • Product descriptionN-(6-Chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide
  • Packaging5mg
  • Price$241
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001089
  • Product descriptionPS-1145 95.00%
  • Packaging5MG
  • Price$272.8
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6089
  • Product descriptionPS-1145
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6089
  • Product descriptionPS-1145
  • Packaging25mg
  • Price$265
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon1568
  • Product descriptionPS1145 99%
  • Packaging2x5mg
  • Price$154
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14862
  • Product descriptionPS-1145 ≥98%
  • Packaging500μg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14862
  • Product descriptionPS-1145 ≥98%
  • Packaging1mg
  • Price$50
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14862
  • Product descriptionPS-1145 ≥98%
  • Packaging5mg
  • Price$130
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5415
  • Product descriptionPS-1145 99.88%
  • Packaging5mg
  • Price$114
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5415
  • Product descriptionPS-1145 99.88%
  • Packaging10mg
  • Price$192
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5415
  • Product descriptionPS-1145 99.88%
  • Packaging25mg
  • Price$396
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5415
  • Product descriptionPS-1145 99.88%
  • Packaging50mg
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5415
  • Product descriptionPS-1145 99.88%
  • Packaging100mg
  • Price$1260
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001915
  • Product descriptionPS-1145 98+%
  • Packaging25mg
  • Price$297
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001915
  • Product descriptionPS-1145 98+%
  • Packaging50mg
  • Price$574
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001915
  • Product descriptionPS-1145 98+%
  • Packaging100mg
  • Price$1015
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 4450CR N-(6-Chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide 5mg $241 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001089 PS-1145 95.00% 5MG $272.8 2021-12-16 Buy
ApexBio Technology B6089 PS-1145 5mg $75 2021-12-16 Buy
ApexBio Technology B6089 PS-1145 25mg $265 2021-12-16 Buy
Axon Medchem Axon1568 PS1145 99% 2x5mg $154 2021-12-16 Buy
Cayman Chemical 14862 PS-1145 ≥98% 500μg $32 2024-03-01 Buy
Cayman Chemical 14862 PS-1145 ≥98% 1mg $50 2024-03-01 Buy
Cayman Chemical 14862 PS-1145 ≥98% 5mg $130 2024-03-01 Buy
ChemScene CS-5415 PS-1145 99.88% 5mg $114 2021-12-16 Buy
ChemScene CS-5415 PS-1145 99.88% 10mg $192 2021-12-16 Buy
ChemScene CS-5415 PS-1145 99.88% 25mg $396 2021-12-16 Buy
ChemScene CS-5415 PS-1145 99.88% 50mg $720 2021-12-16 Buy
ChemScene CS-5415 PS-1145 99.88% 100mg $1260 2021-12-16 Buy
Crysdot CD31001915 PS-1145 98+% 25mg $297 2021-12-16 Buy
Crysdot CD31001915 PS-1145 98+% 50mg $574 2021-12-16 Buy
Crysdot CD31001915 PS-1145 98+% 100mg $1015 2021-12-16 Buy

Properties

Boiling point :511.0±50.0 °C(Predicted)
Density :1.513±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >3mg/mL at ~60°C, clear (with warming for 2 minutes)
pka :11.75±0.43(Predicted)
form :solid
color :yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Nuclear factor-κB (NF-κB) is a protein complex which modulates gene transcription relevant to cellular responses to inflammation, stress, infection, and other factors. The inhibitor of NF-κB kinase β (IKKβ), in complex with IKKα and IKKγ, phosphorylates inhibitor of NF-κB A and B (IκA and IκB) and other proteins involved in NF-κB signaling, and thus plays a central regulatory role. PS-1145 is a potent inhibitor of IKKβ (IC50 = 88-100 nM). Through this action, it is used to elucidate roles for NF-κB both in cells and in vivo.