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ChemicalBook >> CAS DataBase List >> (4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone

(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone

(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone price.
  • $32 - $460
  • Product name: (4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone
  • CAS: 432020-20-7
  • MF: C17H15ClFN3O3
  • MW: 363.7707032
  • EINECS:
  • MDL Number:MFCD03575351
  • Synonyms:(4-Chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)Methanone;1-(4-Chloro-3-nitrobenzoyl)-4-(2-fluorophenyl)-piperazine;SID: 164348711;SMI481;Methanone, (4-chloro-3-nitrophenyl)[4-(2-fluorophenyl)-1-piperazinyl]-;NPPM 6748481;NPPM 6748-481;NPPM6748481
10 prices
Selected condition:
Brand
  • AK Scientific
  • Cayman Chemical
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • ManufacturerAK Scientific
  • Product numberSYN5232
  • Product descriptionSMI481
  • Packaging50mg
  • Price$460
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17637
  • Product descriptionSMI-481 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17637
  • Product descriptionSMI-481 ≥98%
  • Packaging5mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17637
  • Product descriptionSMI-481 ≥98%
  • Packaging10mg
  • Price$169
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17637
  • Product descriptionSMI-481 ≥98%
  • Packaging25mg
  • Price$381
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML1090
  • Product descriptionSMI481 ≥98% (HPLC)
  • Packaging25mg
  • Price$410
  • Updated2022-05-15
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML1090
  • Product descriptionSMI481 ≥98% (HPLC)
  • Packaging5mg
  • Price$102
  • Updated2022-05-15
  • Buy
  • ManufacturerTRC
  • Product numberS566020
  • Product descriptionSMI-481
  • Packaging1mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberS566020
  • Product descriptionSMI-481
  • Packaging5mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number466182
  • Product descriptionSMI-481
  • Packaging1mg
  • Price$319
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5232 SMI481 50mg $460 2021-12-16 Buy
Cayman Chemical 17637 SMI-481 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 17637 SMI-481 ≥98% 5mg $93 2024-03-01 Buy
Cayman Chemical 17637 SMI-481 ≥98% 10mg $169 2024-03-01 Buy
Cayman Chemical 17637 SMI-481 ≥98% 25mg $381 2024-03-01 Buy
Sigma-Aldrich SML1090 SMI481 ≥98% (HPLC) 25mg $410 2022-05-15 Buy
Sigma-Aldrich SML1090 SMI481 ≥98% (HPLC) 5mg $102 2022-05-15 Buy
TRC S566020 SMI-481 1mg $55 2021-12-16 Buy
TRC S566020 SMI-481 5mg $85 2021-12-16 Buy
Usbiological 466182 SMI-481 1mg $319 2021-12-16 Buy

Properties

Boiling point :543.3±50.0 °C(Predicted)
Density :1.411±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear
pka :1.04±0.10(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Phosphatidylinositol (PtdIns) transfer proteins (PITPs) mediate the exchange of PtdIns and phosphatidylcholine between membranes, a step required for a wide array of cellular processes including cell division. SMI-481 is an inhibitor of the yeast PITP Sec14, blocking both Sec14-mediated transfer of [3H]-PtdIns in vitro and growth (IC50s = 0.21 and 2.87 μM, respectively). Suppression of Sec14 expression leads to proportional reduction in SMI-481 inhibition, suggesting that SMI-481 acts specifically through Sec14. Moreover, SMI-481 does not affect [3H]-PtdIns transfer mediated by other yeast PITPs.