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ChemicalBook >> CAS DataBase List >> 15(R)-15-METHYL PROSTAGLANDIN E2

15(R)-15-METHYL PROSTAGLANDIN E2

15(R)-15-METHYL PROSTAGLANDIN E2 price.
  • $86 - $1500
  • Product name: 15(R)-15-METHYL PROSTAGLANDIN E2
  • CAS: 55028-70-1
  • MF: C21H34O5
  • MW: 366.49
  • EINECS:
  • MDL Number:MFCD00216054
  • Synonyms:15(r)-methylprostaglandine2 ;9-OXO-11ALPHA,15R-DIHYDROXY-15-METHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID;ARBAPROSTIL;15(R)-15-METHYL PROSTAGLANDIN E2;(5Z)-7-[(1R,2R)-3α-Hydroxy-2-[(3R,E)-3-hydroxy-3-methyl-1-octenyl]-5-oxocyclopentyl]-5-heptenoic acid;(5Z,11α,13E,15R)-11,15-Dihydroxy-15-methyl-9-oxoprosta-5,13-dien-1-oic acid;CU-83;U-42842
4 prices
Selected condition:
Brand
  • AHH
  • Cayman Chemical
  • Medical Isotopes, Inc.
Package
  • 500μg
  • 1mg
  • 0.01g
  • 25mg
  • ManufacturerAHH
  • Product numberMT-20534
  • Product description9-Oxo-11alpha,15R-dihydroxy-15-methyl-prosta-5Z,13E-dien-1oicacid 98%
  • Packaging0.01g
  • Price$355
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14725
  • Product description15(R)-15-methyl Prostaglandin E2
  • Packaging500μg
  • Price$86
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14725
  • Product description15(R)-15-methyl Prostaglandin E2 ≥98%
  • Packaging1mg
  • Price$161
  • Updated2024-03-01
  • Buy
  • ManufacturerMedical Isotopes, Inc.
  • Product number18484
  • Product descriptionArbaprostil
  • Packaging25mg
  • Price$1500
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-20534 9-Oxo-11alpha,15R-dihydroxy-15-methyl-prosta-5Z,13E-dien-1oicacid 98% 0.01g $355 2021-12-16 Buy
Cayman Chemical 14725 15(R)-15-methyl Prostaglandin E2 500μg $86 2024-03-01 Buy
Cayman Chemical 14725 15(R)-15-methyl Prostaglandin E2 ≥98% 1mg $161 2024-03-01 Buy
Medical Isotopes, Inc. 18484 Arbaprostil 25mg $1500 2021-12-16 Buy

Properties

Boiling point :417.24°C (rough estimate)
Density :1.0525 (rough estimate)
refractive index :1.6120 (estimate)
solubility :DMF: >100 mg/ml (from PGE2); DMSO: >100 mg/ml (from PGE2); Ethanol: >100 mg/ml (from PGE2); PBS pH 7.2: >5 mg/ml (from PGE2)
form :A crystalline solid
pka :4.75±0.10(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

15(R)-15-methyl Prostaglandin E2 (15(R)-15-methyl PGE2) is a prodrug for the potent PGE2 analog 15(S)-15-methyl PGE2 . Acid-catalyzed epimerization in the stomach produces the 15(S)-hydroxy compound which is biologically active. Oral administration of 15(R)-15-methyl PGE2 to dogs or rats at 10-300 μg/kg results in a dose-dependent inhibition of gastric acid secretion and an increase in the rate of duodenal bicarbonate secretion.

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