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ChemicalBook >> CAS DataBase List >> DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE

DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE

DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE price.
  • $62 - $379
  • Product name: DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE
  • CAS: 64005-90-9
  • MF: C22H18N2O8
  • MW: 438.39
  • EINECS:
  • MDL Number:MFCD00333607
  • Synonyms:PIB;DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE;WNKQGFNIIHNGQM-UHFFFAOYSA-N;PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem;Benzo[lmn][3,8]phenanthroline-2,7-diacetic acid, 1,3,6,8-tetrahydro-1,3,6,8-tetraoxo-, 2,7-diethyl ester;PiB >=98% (HPLC);PPIase-Parvulin inhibitor,Inhibitor,PPIase Parvulin Inhibitor,PPIaseParvulin Inhibitor,inhibit;diethyl 2,2'-(1,3,6,8-tetraoxo-1,3,6,8-tetrahydrobenzo[lmn][3,8]phenanthroline-2,7-diyl)diacetate
Price8 Properties Safety Information Description
8 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • Sigma-Aldrich
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • ManufacturerAK Scientific
  • Product number8702BA
  • Product descriptionPPIase-Parvulin Inhibitor
  • Packaging5mg
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3022
  • Product descriptionPPIase-Parvulin Inhibitor
  • Packaging5mg
  • Price$88
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3022
  • Product descriptionPPIase-Parvulin Inhibitor
  • Packaging10mg
  • Price$139
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17214
  • Product descriptionPPIase-Parvulin Inhibitor ≥95%
  • Packaging1mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17214
  • Product descriptionPPIase-Parvulin Inhibitor ≥95%
  • Packaging5mg
  • Price$120
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17214
  • Product descriptionPPIase-Parvulin Inhibitor ≥95%
  • Packaging10mg
  • Price$211
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberB7688
  • Product descriptionPiB ≥98% (HPLC)
  • Packaging5mg
  • Price$118
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberB7688
  • Product descriptionPiB ≥98% (HPLC)
  • Packaging25mg
  • Price$379
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 8702BA PPIase-Parvulin Inhibitor 5mg $185 2021-12-16 Buy
ApexBio Technology C3022 PPIase-Parvulin Inhibitor 5mg $88 2021-12-16 Buy
ApexBio Technology C3022 PPIase-Parvulin Inhibitor 10mg $139 2021-12-16 Buy
Cayman Chemical 17214 PPIase-Parvulin Inhibitor ≥95% 1mg $62 2024-03-01 Buy
Cayman Chemical 17214 PPIase-Parvulin Inhibitor ≥95% 5mg $120 2024-03-01 Buy
Cayman Chemical 17214 PPIase-Parvulin Inhibitor ≥95% 10mg $211 2024-03-01 Buy
Sigma-Aldrich B7688 PiB ≥98% (HPLC) 5mg $118 2024-03-01 Buy
Sigma-Aldrich B7688 PiB ≥98% (HPLC) 25mg $379 2024-03-01 Buy

Properties

storage temp. :2-8°C
solubility :DMSO: soluble1-2mg/mL (warmed)
form :Brownish solid
color :white to light brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

Peptidyl-prolyl isomerases (PPIases) assist in the folding of newly-synthesized proteins, regulating the stability, localization, and activity of mature proteins. PPIase-Parvulin Inhibitor is a cell-permeable inhibitor of the PPIases Pin1 and Pin4 (IC50s = 1.5 and 1.0 μM, respectively), interacting with the PPIase domain. It blocks the proliferation of cancer cells that overexpress Pin1 and Pin4 (IC50 range = 2-5 μM), and similarly inhibits wild type mouse embryonic fibroblasts (MEFs) but not Pin1-/- MEFs. PPIase-Parvulin Inhibitor does not inhibit topoisomerase I or bind DNA. Also referred to as PiB, this compound is commonly used to determine the role of Pin1 in regulating various substrates and cellular functions.

Suppliers and manufacturers

TargetMol Chemicals Inc.
Aladdin Scientific Beijing Yusheng Chemical Co., Ltd. Shanghai Rechem science Co., Ltd. ChemeGen(Shanghai) Biotechnology Co.,Ltd. MedBioPharmaceutical Technology Inc Energy Chemical Wuhan Yingnuo Pharmaceutical Technology Co., Ltd. TargetMol Chemicals Inc. Shanghai Yifei Biotechnology Co. , Ltd.