GW843682, 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide
![GW843682, 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide price.](/CAS/GIF/660868-91-7.gif)
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- $57 - $1800
- Product name: GW843682, 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide
- CAS: 660868-91-7
- MF: C22H18F3N3O4S
- MW: 477.46
- EINECS:200-258-5
- MDL Number:MFCD09971143
- Synonyms:GW843682, 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide;GW843682X;3-(2-(Trifluoromethyl)benzyloxy)-5-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)thiophene-2-carboxamide;Polo-like Kinase Inhibitor III;5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(trifluoromethyl)-benzyl]oxy}thiophene-2-carboxamide;5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoromethyl)phenyl]methoxy]-2-thiophenecarboxamide;GW843682;5-(5,6-dimethoxy-1H-benzo[d]imidazol-1-yl)-3-((2-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxamide
18 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10
- 1
- 500μg
- 1MG
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000123
- Product descriptionGW 843682X 95.00%
- Packaging1MG
- Price$617.3
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3456
- Product descriptionGW843682X
- Packaging10mg
- Price$213
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1131
- Product descriptionGW843682X 99%
- Packaging5mg
- Price$82.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number28759
- Product descriptionGW843682X
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28759
- Product descriptionGW843682X
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28759
- Product descriptionGW843682X
- Packaging10mg
- Price$249
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0070
- Product descriptionGW843682X 99.84%
- Packaging5mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0070
- Product descriptionGW843682X 99.84%
- Packaging10mg
- Price$144
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0070
- Product descriptionGW843682X 99.84%
- Packaging50mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8609
- Product descriptionGW843682X >98%
- Packaging100mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8609
- Product descriptionGW843682X >98%
- Packaging250mg
- Price$900
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC8609
- Product descriptionGW843682X >98%
- Packaging1g
- Price$1800
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number528284
- Product descriptionPolo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem
- Packaging500μg
- Price$140
- Updated2023-01-07
- Buy
- ManufacturerSigma-Aldrich
- Product numberG2171
- Product descriptionGW843682X ≥98% (HPLC), solid
- Packaging1mg
- Price$178
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberG2171
- Product descriptionGW843682X ≥98% (HPLC), solid
- Packaging5mg
- Price$567
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number2977
- Product descriptionGW843682X ≥98%(HPLC)
- Packaging1
- Price$101
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | KIN0000123 | GW 843682X 95.00% | 1MG | $617.3 | 2021-12-16 | Buy |
| ApexBio Technology | A3456 | GW843682X | 10mg | $213 | 2021-12-16 | Buy |
| Axon Medchem | Axon1131 | GW843682X 99% | 5mg | $82.5 | 2021-12-16 | Buy |
| Cayman Chemical | 28759 | GW843682X | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 28759 | GW843682X | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 28759 | GW843682X | 10mg | $249 | 2024-03-01 | Buy |
| ChemScene | CS-0070 | GW843682X 99.84% | 5mg | $84 | 2021-12-16 | Buy |
| ChemScene | CS-0070 | GW843682X 99.84% | 10mg | $144 | 2021-12-16 | Buy |
| ChemScene | CS-0070 | GW843682X 99.84% | 50mg | $540 | 2021-12-16 | Buy |
| DC Chemicals | DC8609 | GW843682X >98% | 100mg | $450 | 2021-12-16 | Buy |
| DC Chemicals | DC8609 | GW843682X >98% | 250mg | $900 | 2021-12-16 | Buy |
| DC Chemicals | DC8609 | GW843682X >98% | 1g | $1800 | 2021-12-16 | Buy |
| Sigma-Aldrich | 528284 | Polo-like Kinase Inhibitor III - CAS 660868-91-7 - Calbiochem | 500μg | $140 | 2023-01-07 | Buy |
| Sigma-Aldrich | G2171 | GW843682X ≥98% (HPLC), solid | 1mg | $178 | 2024-03-01 | Buy |
| Sigma-Aldrich | G2171 | GW843682X ≥98% (HPLC), solid | 5mg | $567 | 2024-03-01 | Buy |
| Tocris | 2977 | GW843682X ≥98%(HPLC) | 1 | $101 | 2021-12-16 | Buy |
Properties
Boiling point :609.1±65.0 °C(Predicted)
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
pka :15.03±0.50(Predicted)
form :solid
color :off-white
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >10mg/mL
pka :15.03±0.50(Predicted)
form :solid
color :off-white
Safety Information
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Description
Polo-like Kinase Inhibitor III (GW843682X) is a cell-permeable thiophene-benzimidazole compound that acts as a potent and reversible inhibitor against Plk (polo-like kinases) (Ki against Plk1/2/3/4 = 4.8, 3.8, 8.0, and 163 nM , respectively), while exhibiting little or much reduced activity against 39 other commonly studied kinases. Polo-like Kinase Inhibitor III preferentially inhibits the proliferation of a panel of 11 tumor cell lines (IC50 ≤0.7 μM) over normal human diploid fibroblasts (IC50 = 6.14 μM) in culture and is equally potent against the mdr-1-expressing MES-SA/DX5 and its parent non-drug resistant MES-SA uterine sarcoma cell line.Related product price
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