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ChemicalBook >> CAS DataBase List >> DL-THREO-DIHYDROSPHINGOSINE

DL-THREO-DIHYDROSPHINGOSINE

DL-THREO-DIHYDROSPHINGOSINE price.
Price4 Properties Safety Information Description
4 prices
Selected condition：
Brand
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • TRC
Package
  • 1MG
  • 10mg
  • 25mg
  • ManufacturerAlfa Aesar
  • Product numberJ67428
  • Product descriptionDL-threo-Dihydrosphingosine, 98%
  • Packaging10mg
  • Price$111
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberLIP0000378
  • Product descriptionDL-THREO-DIHYDROSPHINGOSINE 95.00%
  • Packaging1MG
  • Price$642.76
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberLIP0000378
  • Product descriptionDL-THREO-DIHYDROSPHINGOSINE 95.00%
  • Packaging10MG
  • Price$742.33
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberD689955
  • Product descriptionDL-threo-Dihydrosphingosine
  • Packaging25mg
  • Price$330
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Alfa Aesar J67428 DL-threo-Dihydrosphingosine, 98% 10mg $111 2021-12-16 Buy
American Custom Chemicals Corporation LIP0000378 DL-THREO-DIHYDROSPHINGOSINE 95.00% 1MG $642.76 2021-12-16 Buy
American Custom Chemicals Corporation LIP0000378 DL-THREO-DIHYDROSPHINGOSINE 95.00% 10MG $742.33 2021-12-16 Buy
TRC D689955 DL-threo-Dihydrosphingosine 25mg $330 2021-12-16 Buy

Properties

storage temp. :−20°C
form :Solid

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

DL-threo-Dihydrosphingosine is an inhibitor of Sphk (sphingosine kinase). This inhibitory activity has been employed as a tool for identifying the activity of sphingosine kinase in various processes. A role of sphingosine-1-phosphate generated by sphingosine kinase is suggested in the mobilization of Ca2+ stimulated by local discrete increases in intracellular Ca2+ at m2 and m3 muscarinic acetylcholine receptors. DL-threo-Dihydrosphingosine demonstrates inhibition of Ca2+ mobilization, and modulation of this process is suggested to function as an amplification for Ca2+ signals mediated by sphingosine kinase activity. The extracellular signal-regulated kinase (ERK) pathway is inhibited by DL-threo-Dihydrosphingosine, suggesting participation of sphingosine kinase in this pathway. DL-threo-Dihydrosphingosine was demonstrated to increase the sensitivity of HEK-293 cells to fumonisin B1cytotoxicity, indicating that fumonisin B1 resistance in HEK-293 cells involves rapid formation of sphingosine-1-phosphate by sphingosine kinase which confers survival properties to the cells.

Suppliers and manufacturers

Aladdin Scientific Energy Chemical