Acotiamide hydrochloride trihydrate
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- $5 - $980
- Product name: Acotiamide hydrochloride trihydrate
- CAS: 773092-05-0
- MF: C21H31ClN4O5S
- MW: 487.013
- EINECS:1592732-453-0
- MDL Number:MFCD28101055
- Synonyms:N-(2-(Diisopropylamino)ethyl)-2-((2-hydroxy-4,5-dimethoxybenzoyl)amino)-1,3-thiazole-4-carboxyamide monohydrochloride trihydrate;Unii-nmw7447A9a;Ym-443;AcotiaMide hydrochloride trihydrate;Acotiae;4-Thiazolecarboxamide, N-[2-[bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-,hydrochloride,hydrate(1:1:3);Acofide trihydrate;N-{2-[bis(1-methylethyl)amino]ethyl}-2-[(2-hydroxy-4,5-dimethoxyphenylcarbonyl)amino]
21 prices
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Brand
- AK Scientific
- Ambeed
- Biosynth Carbosynth
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- TRC
Package
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1g
- 2g
- 5g
- 10g
- ManufacturerAK Scientific
- Product number0099AP
- Product descriptionAcotiamidehydrochloridehydrate
- Packaging1g
- Price$185
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA254230
- Product descriptionAcotiamidehydrochloridetrihydrate 99%
- Packaging50mg
- Price$5
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA254230
- Product descriptionAcotiamidehydrochloridetrihydrate 99%
- Packaging100mg
- Price$6
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA254230
- Product descriptionAcotiamidehydrochloridetrihydrate 99%
- Packaging250mg
- Price$8
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA254230
- Product descriptionAcotiamidehydrochloridetrihydrate 99%
- Packaging1g
- Price$22
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA254230
- Product descriptionAcotiamidehydrochloridetrihydrate 99%
- Packaging5g
- Price$73
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA137643
- Product descriptionAcotiamide HCl hydrate
- Packaging100mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA137643
- Product descriptionAcotiamide HCl hydrate
- Packaging250mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA137643
- Product descriptionAcotiamide HCl hydrate
- Packaging500mg
- Price$230
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA137643
- Product descriptionAcotiamide HCl hydrate
- Packaging1g
- Price$350
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA137643
- Product descriptionAcotiamide HCl hydrate
- Packaging2g
- Price$440
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM190280
- Product descriptionN-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamidehydrochloridetrihydrate 95%
- Packaging1g
- Price$102
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM190280
- Product descriptionN-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamidehydrochloridetrihydrate 95%
- Packaging5g
- Price$281
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM190280
- Product descriptionN-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamidehydrochloridetrihydrate 95%
- Packaging10g
- Price$468
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0020306
- Product descriptionAcotiamide(monohydrochloridetrihydrate) 99.28%
- Packaging100mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD11059134
- Product descriptionAcotiamidehydrochloridetrihydrate 95+%
- Packaging5g
- Price$297
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | 0099AP | Acotiamidehydrochloridehydrate | 1g | $185 | 2021-12-16 | Buy |
Ambeed | A254230 | Acotiamidehydrochloridetrihydrate 99% | 50mg | $5 | 2021-12-16 | Buy |
Ambeed | A254230 | Acotiamidehydrochloridetrihydrate 99% | 100mg | $6 | 2021-12-16 | Buy |
Ambeed | A254230 | Acotiamidehydrochloridetrihydrate 99% | 250mg | $8 | 2021-12-16 | Buy |
Ambeed | A254230 | Acotiamidehydrochloridetrihydrate 99% | 1g | $22 | 2021-12-16 | Buy |
Ambeed | A254230 | Acotiamidehydrochloridetrihydrate 99% | 5g | $73 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA137643 | Acotiamide HCl hydrate | 100mg | $80 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA137643 | Acotiamide HCl hydrate | 250mg | $150 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA137643 | Acotiamide HCl hydrate | 500mg | $230 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA137643 | Acotiamide HCl hydrate | 1g | $350 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA137643 | Acotiamide HCl hydrate | 2g | $440 | 2021-12-16 | Buy |
Chemenu | CM190280 | N-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamidehydrochloridetrihydrate 95% | 1g | $102 | 2021-12-16 | Buy |
Chemenu | CM190280 | N-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamidehydrochloridetrihydrate 95% | 5g | $281 | 2021-12-16 | Buy |
Chemenu | CM190280 | N-(2-(Diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamidehydrochloridetrihydrate 95% | 10g | $468 | 2021-12-16 | Buy |
ChemScene | CS-0020306 | Acotiamide(monohydrochloridetrihydrate) 99.28% | 100mg | $50 | 2021-12-16 | Buy |
Crysdot | CD11059134 | Acotiamidehydrochloridetrihydrate 95+% | 5g | $297 | 2021-12-16 | Buy |
Properties
Melting point :193-195o C
storage temp. :2-8°C
solubility :Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly) Methanol (Slightly)
form :Solid
color :Pale Yellow
storage temp. :2-8°C
solubility :Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly) Methanol (Slightly)
form :Solid
color :Pale Yellow
Safety Information
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Description
In June 2013, the Ministry of Health, Labor and Welfare in Japan approved acotiamide (also referred to as Z-338 and YM443), for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia (FD). Acotiamide enhances acetylcholine release from enteric neurons through selective muscarinic acetylcholine receptor M1, M2 antagonism, and inhibition of AChE, thereby enhancing gastric emptying and gastric accommodation. Acotiamide inhibits the acetylcholine-induced Ca2+-activated Cl-current with an IC50 of 1.8 μM in oocytes expressing muscarinic M1 receptors and in oocytes expressing muscarinic M2 receptors, acotiamide inhibited the acetylcholine-induced K+ currents with an IC50 of 10.1 μM. However, studies in conscious dogs, guinea-pig gastric muscle strips and assays with human cholinesterase indicate that acotiamide inhibits AChE with a Ki of 610 nM suggesting that acotiamide stimulates gastric motility mainly by inhibiting AChE activation. In a restraint stress-induced rat model, acotiamide significantly improved delayed gastric emptying and feeding inhibition but did not affect normal gastric emptying or feeding in intact rats. A synthetic route to acotiamide that employs pyridine hydrochloride to selectively cleave a 2-substituted methyl ether from a 2,4,5-trimethoxy benzamide intermediate, as a key step, has been reported.More related product prices
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Suppliers and manufacturers
Beijing Cooperate Pharmaceutical Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
Hangzhou FandaChem Co.,Ltd.
Shanghai Yingrui Biopharma Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Lianyungang happen teng technology co., LTD
Shaanxi Yikanglong Biotechnology Co., Ltd.
Anhui Dexinjia Biopharm Co., Ltd