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ChemicalBook >> CAS DataBase List >> (4Z)-7-[(REL-1S,2S,5R)-5-((1,1'-BIPHENYL-4-YL)METHOXY)-2-(4-MORPHOLINYL)-3-OXOCYCLOPENTYL]-4-HEPTENOIC ACID CALCIUM SALT

(4Z)-7-[(REL-1S,2S,5R)-5-((1,1'-BIPHENYL-4-YL)METHOXY)-2-(4-MORPHOLINYL)-3-OXOCYCLOPENTYL]-4-HEPTENOIC ACID CALCIUM SALT

(4Z)-7-[(REL-1S,2S,5R)-5-((1,1'-BIPHENYL-4-YL)METHOXY)-2-(4-MORPHOLINYL)-3-OXOCYCLOPENTYL]-4-HEPTENOIC ACID CALCIUM SALT price.
10 prices
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  • ApexBio Technology
  • Cayman Chemical
  • Sigma-Aldrich
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • ManufacturerApexBio Technology
  • Product numberC5649
  • Product descriptionAH23848(calciumsalt)
  • Packaging1mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5649
  • Product descriptionAH23848(calciumsalt)
  • Packaging5mg
  • Price$270
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5649
  • Product descriptionAH23848(calciumsalt)
  • Packaging10mg
  • Price$497
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5649
  • Product descriptionAH23848(calciumsalt)
  • Packaging25mg
  • Price$947
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19023
  • Product descriptionAH 23848 (calcium salt) ≥90%
  • Packaging1mg
  • Price$82
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19023
  • Product descriptionAH 23848 (calcium salt) ≥90%
  • Packaging5mg
  • Price$266
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19023
  • Product descriptionAH 23848 (calcium salt) ≥90%
  • Packaging10mg
  • Price$490
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19023
  • Product descriptionAH 23848 (calcium salt) ≥90%
  • Packaging25mg
  • Price$739
  • Updated2023-01-06
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberA8227
  • Product descriptionAH23848 hemicalcium salt ≥90% (HPLC), powder
  • Packaging5mg
  • Price$177.6
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberA8227
  • Product descriptionAH23848 hemicalcium salt ≥90% (HPLC), powder
  • Packaging25mg
  • Price$1020
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology C5649 AH23848(calciumsalt) 1mg $90 2021-12-16 Buy
ApexBio Technology C5649 AH23848(calciumsalt) 5mg $270 2021-12-16 Buy
ApexBio Technology C5649 AH23848(calciumsalt) 10mg $497 2021-12-16 Buy
ApexBio Technology C5649 AH23848(calciumsalt) 25mg $947 2021-12-16 Buy
Cayman Chemical 19023 AH 23848 (calcium salt) ≥90% 1mg $82 2024-03-01 Buy
Cayman Chemical 19023 AH 23848 (calcium salt) ≥90% 5mg $266 2024-03-01 Buy
Cayman Chemical 19023 AH 23848 (calcium salt) ≥90% 10mg $490 2024-03-01 Buy
Cayman Chemical 19023 AH 23848 (calcium salt) ≥90% 25mg $739 2023-01-06 Buy
Sigma-Aldrich A8227 AH23848 hemicalcium salt ≥90% (HPLC), powder 5mg $177.6 2024-03-01 Buy
Sigma-Aldrich A8227 AH23848 hemicalcium salt ≥90% (HPLC), powder 25mg $1020 2024-03-01 Buy

Properties

storage temp. :-20°C
solubility :DMSO: 18 mg/mL at ≤60 °C
form :solid
color :off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Thromboxane (TXA2) activates the T prostanoid (TP) receptor. Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. AH-23848 is a dual antagonist of TP and EP4 receptors. It originally was found to inhibit TXA2-induced platelet aggregation (IC50 = 0.26 μM) and the contraction of human bronchial smooth muscle induced by the TP agonist U-46619. AH-23848 was subsequently demonstrated to impair PGE2-mediated relaxation of piglet saphenous vein by antagonizing the PGE2 receptor EP4. By inhibiting EP4, it likewise suppresses serum-induced cAMP generation, cyclin A synthesis, and the proliferation of fibroblasts, as well as reduces metastasis in a mouse model of metastatic breast cancer.