5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
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- $40 - $2850
- Product name: 5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
- CAS: 852391-15-2
- MF: C13H12ClN3O2
- MW: 277.71
- EINECS:
- MDL Number:MFCD19443135
- Synonyms:5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione);5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione;Necrostatin 2 (raceMate);Necrostatin-2 raceMate;2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-;5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione;Nec-1s(7-Cl-O-Nec1);RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem
13 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Chemenu
- Crysdot
- DC Chemicals
- Sigma-Aldrich
Package
- 1mg
- 5mg
- 10mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number8960CC
- Product descriptionNecrostatin2racemate
- Packaging5mg
- Price$221
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number8960CC
- Product descriptionNecrostatin2racemate
- Packaging10mg
- Price$322
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number20924
- Product description(±)-Necrostatin-2 ≥98%
- Packaging1mg
- Price$40
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20924
- Product description(±)-Necrostatin-2 ≥98%
- Packaging5mg
- Price$118
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number20924
- Product description(±)-Necrostatin-2 ≥98%
- Packaging10mg
- Price$216
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM294579
- Product description5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione 95%+
- Packaging50mg
- Price$1262
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000602
- Product descriptionNecrostatin2racemate 98+%
- Packaging5mg
- Price$300
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000602
- Product descriptionNecrostatin2racemate 98+%
- Packaging10mg
- Price$540
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000602
- Product descriptionNecrostatin2racemate 98+%
- Packaging50mg
- Price$1350
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10551
- Product descriptionNecrostatin2racemate >98%
- Packaging100mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10551
- Product descriptionNecrostatin2racemate >98%
- Packaging250mg
- Price$1500
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10551
- Product descriptionNecrostatin2racemate >98%
- Packaging1g
- Price$2850
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number5.04297
- Product descriptionRIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem
- Packaging10mg
- Price$258
- Updated2023-01-07
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8960CC | Necrostatin2racemate | 5mg | $221 | 2021-12-16 | Buy |
| AK Scientific | 8960CC | Necrostatin2racemate | 10mg | $322 | 2021-12-16 | Buy |
| Cayman Chemical | 20924 | (±)-Necrostatin-2 ≥98% | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 20924 | (±)-Necrostatin-2 ≥98% | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 20924 | (±)-Necrostatin-2 ≥98% | 10mg | $216 | 2024-03-01 | Buy |
| Chemenu | CM294579 | 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione 95%+ | 50mg | $1262 | 2021-12-16 | Buy |
| Crysdot | CD31000602 | Necrostatin2racemate 98+% | 5mg | $300 | 2021-12-16 | Buy |
| Crysdot | CD31000602 | Necrostatin2racemate 98+% | 10mg | $540 | 2021-12-16 | Buy |
| Crysdot | CD31000602 | Necrostatin2racemate 98+% | 50mg | $1350 | 2021-12-16 | Buy |
| DC Chemicals | DC10551 | Necrostatin2racemate >98% | 100mg | $750 | 2021-12-16 | Buy |
| DC Chemicals | DC10551 | Necrostatin2racemate >98% | 250mg | $1500 | 2021-12-16 | Buy |
| DC Chemicals | DC10551 | Necrostatin2racemate >98% | 1g | $2850 | 2021-12-16 | Buy |
| Sigma-Aldrich | 5.04297 | RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem | 10mg | $258 | 2023-01-07 | Buy |
Properties
Melting point :173-175℃
Density :1.450±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 25 mg/ml).
form :Off-white to pale yellow solid
pka :8.48±0.70(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Density :1.450±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 25 mg/ml).
form :Off-white to pale yellow solid
pka :8.48±0.70(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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Description
7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50?= 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2?7-Cl-O-Nec1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4?7-Cl-O-Nec1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50?= 210 nM vs. EC50?= 490 nM), no non-specific cytotoxicity at high concentrations (100 μM) and reasonable pharmacokinetic characteristics when used in mice.2?7-Cl-O-Nec1 is recommended for cellular and?in vivo?use over Necrostatin-1.5More related product prices
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