Welcome to chemicalbook!
400-158-6606
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook >> CAS DataBase List >> 5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)

5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)

5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione) price.
  • $40 - $2850
  • Product name: 5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione)
  • CAS: 852391-15-2
  • MF: C13H12ClN3O2
  • MW: 277.71
  • EINECS:
  • MDL Number:MFCD19443135
  • Synonyms:5-((7-Cl-1H-indol-3-yl)Methyl)-3-MethyliMidazolidine-2,4-dione);5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione;Necrostatin 2 (raceMate);Necrostatin-2 raceMate;2,4-IMidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)Methyl]-3-Methyl-;5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione;Nec-1s(7-Cl-O-Nec1);RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem
13 prices
Selected condition:
Brand
  • AK Scientific
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
Package
  • 1mg
  • 5mg
  • 10mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number8960CC
  • Product descriptionNecrostatin2racemate
  • Packaging5mg
  • Price$221
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number8960CC
  • Product descriptionNecrostatin2racemate
  • Packaging10mg
  • Price$322
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number20924
  • Product description(±)-Necrostatin-2 ≥98%
  • Packaging1mg
  • Price$40
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20924
  • Product description(±)-Necrostatin-2 ≥98%
  • Packaging5mg
  • Price$118
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number20924
  • Product description(±)-Necrostatin-2 ≥98%
  • Packaging10mg
  • Price$216
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM294579
  • Product description5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione 95%+
  • Packaging50mg
  • Price$1262
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000602
  • Product descriptionNecrostatin2racemate 98+%
  • Packaging5mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000602
  • Product descriptionNecrostatin2racemate 98+%
  • Packaging10mg
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000602
  • Product descriptionNecrostatin2racemate 98+%
  • Packaging50mg
  • Price$1350
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10551
  • Product descriptionNecrostatin2racemate >98%
  • Packaging100mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10551
  • Product descriptionNecrostatin2racemate >98%
  • Packaging250mg
  • Price$1500
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10551
  • Product descriptionNecrostatin2racemate >98%
  • Packaging1g
  • Price$2850
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number5.04297
  • Product descriptionRIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem
  • Packaging10mg
  • Price$258
  • Updated2023-01-07
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 8960CC Necrostatin2racemate 5mg $221 2021-12-16 Buy
AK Scientific 8960CC Necrostatin2racemate 10mg $322 2021-12-16 Buy
Cayman Chemical 20924 (±)-Necrostatin-2 ≥98% 1mg $40 2024-03-01 Buy
Cayman Chemical 20924 (±)-Necrostatin-2 ≥98% 5mg $118 2024-03-01 Buy
Cayman Chemical 20924 (±)-Necrostatin-2 ≥98% 10mg $216 2024-03-01 Buy
Chemenu CM294579 5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione 95%+ 50mg $1262 2021-12-16 Buy
Crysdot CD31000602 Necrostatin2racemate 98+% 5mg $300 2021-12-16 Buy
Crysdot CD31000602 Necrostatin2racemate 98+% 10mg $540 2021-12-16 Buy
Crysdot CD31000602 Necrostatin2racemate 98+% 50mg $1350 2021-12-16 Buy
DC Chemicals DC10551 Necrostatin2racemate >98% 100mg $750 2021-12-16 Buy
DC Chemicals DC10551 Necrostatin2racemate >98% 250mg $1500 2021-12-16 Buy
DC Chemicals DC10551 Necrostatin2racemate >98% 1g $2850 2021-12-16 Buy
Sigma-Aldrich 5.04297 RIP1 Inhibitor II, 7-Cl-O-Nec-1 - Calbiochem 10mg $258 2023-01-07 Buy

Properties

Melting point :173-175℃
Density :1.450±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 25 mg/ml).
form :Off-white to pale yellow solid
pka :8.48±0.70(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

7-Cl-O-Nec1 (852391-15-2) is a necrostatin-1 (Cat.# 10-1162) analogue with superior potency (IC50?= 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2?7-Cl-O-Nec1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4?7-Cl-O-Nec1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50?= 210 nM vs. EC50?= 490 nM), no non-specific cytotoxicity at high concentrations (100 μM) and reasonable pharmacokinetic characteristics when used in mice.2?7-Cl-O-Nec1 is recommended for cellular and?in vivo?use over Necrostatin-1.5

Related product price