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ChemicalBook >> CAS DataBase List >> 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione

4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione

4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione price.
  • $33 - $1286
  • Product name: 4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione
  • CAS: 865854-05-3
  • MF: C19H14N2O2S
  • MW: 334.39
  • EINECS:640-411-8
  • MDL Number:MFCD18633296
  • Synonyms:4-Benzyl-2-(naphthalen-1-yl)-[1,2,4]thiadiazolidine-3,5-dione;Tideglusib(NP-031112);TIDEGLUSIB;NP-12;NP031112;NP 031112;NP-031112;1,2,4-Thiadiazolidine-3,5-dione, 2-(1-naphthalenyl)-4-(phenylmethyl)-;Destructible;Tideglusib (NP031112, NP-12)
24 prices
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Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 5MG
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberX5395
  • Product description4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
  • Packaging1g
  • Price$1286
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0014171
  • Product descriptionTIDEGLUSIB 95.00%
  • Packaging5MG
  • Price$141.9
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1539
  • Product descriptionTideglusib
  • Packaging200mg
  • Price$330
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60383
  • Product descriptionTideglusib ≥98%
  • Packaging20mg
  • Price$208
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT30356
  • Product descriptionTideglusib
  • Packaging10mg
  • Price$45
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT30356
  • Product descriptionTideglusib
  • Packaging25mg
  • Price$88.75
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT30356
  • Product descriptionTideglusib
  • Packaging50mg
  • Price$137.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT30356
  • Product descriptionTideglusib
  • Packaging100mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFT30356
  • Product descriptionTideglusib
  • Packaging250mg
  • Price$375
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16727
  • Product descriptionTideglusib ≥98%
  • Packaging5mg
  • Price$33
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16727
  • Product descriptionTideglusib ≥98%
  • Packaging10mg
  • Price$62
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16727
  • Product descriptionTideglusib ≥98%
  • Packaging25mg
  • Price$96
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16727
  • Product descriptionTideglusib ≥98%
  • Packaging50mg
  • Price$129
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM141477
  • Product description4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione 98%
  • Packaging100mg
  • Price$209
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0613
  • Product descriptionTideglusib 99.66%
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0613
  • Product descriptionTideglusib 99.66%
  • Packaging50mg
  • Price$168
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X5395 4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione 1g $1286 2021-12-16 Buy
American Custom Chemicals Corporation API0014171 TIDEGLUSIB 95.00% 5MG $141.9 2021-12-16 Buy
ApexBio Technology B1539 Tideglusib 200mg $330 2021-12-16 Buy
Arctom CFN60383 Tideglusib ≥98% 20mg $208 2021-12-16 Buy
Biosynth Carbosynth FT30356 Tideglusib 10mg $45 2021-12-16 Buy
Biosynth Carbosynth FT30356 Tideglusib 25mg $88.75 2021-12-16 Buy
Biosynth Carbosynth FT30356 Tideglusib 50mg $137.5 2021-12-16 Buy
Biosynth Carbosynth FT30356 Tideglusib 100mg $225 2021-12-16 Buy
Biosynth Carbosynth FT30356 Tideglusib 250mg $375 2021-12-16 Buy
Cayman Chemical 16727 Tideglusib ≥98% 5mg $33 2024-03-01 Buy
Cayman Chemical 16727 Tideglusib ≥98% 10mg $62 2024-03-01 Buy
Cayman Chemical 16727 Tideglusib ≥98% 25mg $96 2024-03-01 Buy
Cayman Chemical 16727 Tideglusib ≥98% 50mg $129 2024-03-01 Buy
Chemenu CM141477 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione 98% 100mg $209 2021-12-16 Buy
ChemScene CS-0613 Tideglusib 99.66% 10mg $100 2021-12-16 Buy
ChemScene CS-0613 Tideglusib 99.66% 50mg $168 2021-12-16 Buy

Properties

Melting point :148 - 150oC
Boiling point :511.3±43.0 °C(Predicted)
Density :1.393
storage temp. :2-8°C
solubility :DMSO: >15mg/mL
form :powder
pka :-1.51±0.20(Predicted)
color :white to beige
InChIKey :PMJIHLSCWIDGMD-UHFFFAOYSA-N

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity. Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARγ antagonist GW9662 . Interestingly, tideglusib also irreversibly inhibits glycogen synthase kinase-3β (GSK3β) with an IC50 value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 μM without preincubation. Several GSK3 inhibitors, including tideglusib, promote hippocampal neurogenesis both in vitro and in vivo, suggesting suitability in Alzheimer’s therapy.

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