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ChemicalBook >> CAS DataBase List >> 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile price.
  • $57 - $1600
  • Product name: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • CAS: 871307-18-5
  • MF: C21H14ClFN6
  • MW: 404.83
  • EINECS:
  • MDL Number:
  • Synonyms:4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylmethylamino)-1,7-naphthyridine-3-carbonitrile;Tpl2 Kinase Inhibitor;4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile;Tpl2-IN-2p;TC-S 7006;1,7-Naphthyridine-3-carbonitrile, 4-[(3-chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-;Tpl2 Kinase Inhibitor 1;Tpl2 Kinase Inhibitor 1,Tpl-2 Kinase Inhibitor 1
Price20 Properties Safety Information Description
20 prices
Selected condition：
Brand
  • AK Scientific
  • Alichem
  • American Custom Chemicals Corporation
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • Tocris
  • TRC
  • Usbiological
Package
  • 2mg
  • 10
  • 1mg
  • 50
  • 5MG
  • 10mg
  • 25mg
  • 50mg
  • 1g
  • ManufacturerAK Scientific
  • Product number9767CQ
  • Product descriptionTpl2KinaseInhibitor
  • Packaging1mg
  • Price$156
  • Updated2021-12-16
  • Buy
  • ManufacturerAlichem
  • Product number871307185
  • Product description4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile
  • Packaging1g
  • Price$960
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000897
  • Product description4-(3-CHLORO-4-FLUOROPHENYLAMINO)-6-(PYRIDIN-3-YL-METHYLAMINO)-3-CYANO-[1,7]-NAPHTHYRIDINE 95.00%
  • Packaging5MG
  • Price$504.59
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102207
  • Product description4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • Packaging2mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102207
  • Product description4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • Packaging5mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102207
  • Product description4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • Packaging10mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102207
  • Product description4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • Packaging25mg
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFC102207
  • Product description4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile
  • Packaging50mg
  • Price$1600
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19710
  • Product descriptionTpl2 Kinase Inhibitor ≥98%
  • Packaging1mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19710
  • Product descriptionTpl2 Kinase Inhibitor ≥98%
  • Packaging5mg
  • Price$220
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19710
  • Product descriptionTpl2 Kinase Inhibitor ≥98%
  • Packaging10mg
  • Price$302
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19710
  • Product descriptionTpl2 Kinase Inhibitor ≥98%
  • Packaging25mg
  • Price$684
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0011091
  • Product descriptionTpl2KinaseInhibitor1 ≥99.0%
  • Packaging5mg
  • Price$515
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11039730
  • Product description4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile 95+%
  • Packaging5mg
  • Price$720
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD11039730
  • Product description4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile 95+%
  • Packaging10mg
  • Price$1360
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number5240
  • Product descriptionTC-S7006 ≥99%(HPLC)
  • Packaging10
  • Price$270
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9767CQ Tpl2KinaseInhibitor 1mg $156 2021-12-16 Buy
Alichem 871307185 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile 1g $960 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000897 4-(3-CHLORO-4-FLUOROPHENYLAMINO)-6-(PYRIDIN-3-YL-METHYLAMINO)-3-CYANO-[1,7]-NAPHTHYRIDINE 95.00% 5MG $504.59 2021-12-16 Buy
Biosynth Carbosynth FC102207 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile 2mg $160 2021-12-16 Buy
Biosynth Carbosynth FC102207 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile 5mg $300 2021-12-16 Buy
Biosynth Carbosynth FC102207 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile 10mg $500 2021-12-16 Buy
Biosynth Carbosynth FC102207 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile 25mg $1000 2021-12-16 Buy
Biosynth Carbosynth FC102207 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile 50mg $1600 2021-12-16 Buy
Cayman Chemical 19710 Tpl2 Kinase Inhibitor ≥98% 1mg $57 2024-03-01 Buy
Cayman Chemical 19710 Tpl2 Kinase Inhibitor ≥98% 5mg $220 2024-03-01 Buy
Cayman Chemical 19710 Tpl2 Kinase Inhibitor ≥98% 10mg $302 2024-03-01 Buy
Cayman Chemical 19710 Tpl2 Kinase Inhibitor ≥98% 25mg $684 2024-03-01 Buy
ChemScene CS-0011091 Tpl2KinaseInhibitor1 ≥99.0% 5mg $515 2021-12-16 Buy
Crysdot CD11039730 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile 95+% 5mg $720 2021-12-16 Buy
Crysdot CD11039730 4-((3-Chloro-4-fluorophenyl)amino)-6-((pyridin-3-ylmethyl)amino)-1,7-naphthyridine-3-carbonitrile 95+% 10mg $1360 2021-12-16 Buy
Tocris 5240 TC-S7006 ≥99%(HPLC) 10 $270 2021-12-16 Buy
Next Last

Properties

Boiling point :616.3±55.0 °C(Predicted)
Density :1.45
storage temp. :2-8°C
solubility :DMF: 1 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml
form :A crystalline solid
pka :4.80±0.10(Predicted)
color :Yellow to green

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Tpl2 kinase inhibitor is an inhibitor of tumor progression locus 2 (Tpl2; IC50 = 0.05 μM). It is selective for Tpl2 over MEK, p38 MAPK, Src, MK2, and PKC (IC50s = >40, 180, >400, 110, and >400 μM, respectively). Tpl2 kinase inhibitor inhibits LPS-induced TNF-α production in isolated human monocytes and whole blood (IC50s = 0.7 and 8.5 μM, respectively). It enhances differentiation induced by 1,25-dihydroxy vitamin D3 (calcitriol; ) in HL-60 and U937 leukemia cells when used at a concentration of 5 μM. Tpl2 kinase inhibitor (5 μM) inhibits the proliferation of KG-1a leukemia cells.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
Tpl2 Kinase Inhibitor 1
$143.00 /1mg
Tpl2 Kinase Inhibitor 1 CAS:871307-18-5
CONIER CHEM AND PHARMA LIMITED
Wuhan Topule Biopharmaceutical Co., Ltd
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
Shanghai Acmec Biochemical Technology Co., Ltd.
Aladdin Scientific
SHANGHAI KEAN TECHNOLOGY CO., LTD. Shanghai EFE Biological Technology Co., Ltd. Aikon International Limited Shanghai Hongye Biotechnology Co. Ltd