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ChemicalBook >> CAS DataBase List >> 1,1′-[(2-Phenyl-1-buten-1-ylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl)]bis-pyrrolidine

1,1′-[(2-Phenyl-1-buten-1-ylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl)]bis-pyrrolidine

1,1′-[(2-Phenyl-1-buten-1-ylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl)]bis-pyrrolidine price.
Price7 Properties Safety Information Description
7 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • TRC
Package
  • 1mg
  • 5MG
  • 10mg
  • 25MG
  • 100mg
  • ManufacturerAK Scientific
  • Product numberSYN5505
  • Product descriptionRidaifen-B
  • Packaging100mg
  • Price$2389
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008310
  • Product descriptionRIDAIFEN-B 95.00%
  • Packaging5MG
  • Price$808.68
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008310
  • Product descriptionRIDAIFEN-B 95.00%
  • Packaging25MG
  • Price$1449.24
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number21966
  • Product descriptionRidaifen-B
  • Packaging1mg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21966
  • Product descriptionRidaifen-B
  • Packaging5mg
  • Price$238
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number21966
  • Product descriptionRidaifen-B
  • Packaging10mg
  • Price$435
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberR495963
  • Product descriptionRidaifen-B
  • Packaging5mg
  • Price$180
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5505 Ridaifen-B 100mg $2389 2021-12-16 Buy
American Custom Chemicals Corporation API0008310 RIDAIFEN-B 95.00% 5MG $808.68 2021-12-16 Buy
American Custom Chemicals Corporation API0008310 RIDAIFEN-B 95.00% 25MG $1449.24 2021-12-16 Buy
Cayman Chemical 21966 Ridaifen-B 1mg $81 2024-03-01 Buy
Cayman Chemical 21966 Ridaifen-B 5mg $238 2024-03-01 Buy
Cayman Chemical 21966 Ridaifen-B 10mg $435 2024-03-01 Buy
TRC R495963 Ridaifen-B 5mg $180 2021-12-16 Buy

Properties

Melting point :108-109 °C(Solv: acetonitrile (75-05-8))
Boiling point :644.1±55.0 °C(Predicted)
Density :1.091±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥13mg/mL
form :white solid
pka :9.93±0.20(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Ridaifen-B is a novel tamoxifen (TAM) analog which significantly augments apoptosis-inducing effect of TAM in estrogen receptor (ER)-negatives cells. It induces mitochondria-involved apoptosis in Jurkat cells, as evidenced by chromatin-condensed cells as well as downstream activation of caspases (caspase-3, -8 and -9) in a dose- and time-dependent manner. At 4 hours of incubation, IC50 for RID-B is 4 μM (30 μM for TAM). And at prolonged treatment of 48 hours, IC50 for RID-B is 0.1 μM. In a related report on the global anti-tumor activity, RID-B strongly inhibits 39 human cancer cells (JFCR 39), both ER-+ or ER-- at concentrations of equal or less than 1 μM (e.g., at 0.38 μM for SF-539 [central nervous system], at 0.58 μM for HT-29 [colon], at 0.20 μM for DMS114 [lung], at 0.21μM for LOX-IMVI [melanoma], and at 0.23 μM for MKN74 [stomach]. The binding protein of RID-B that exerts the apoptosis events is currently under investigation.

Suppliers and manufacturers

TargetMol Chemicals Inc.
Aladdin Scientific Shanghai EFE Biological Technology Co., Ltd. Shanghai Hongye Biotechnology Co. Ltd BOC Sciences ChemeGen(Shanghai) Biotechnology Co.,Ltd. Changzhou Furuisi Biotechnology Co., Ltd TargetMol Chemicals Inc.