(E)-N-(4-acetylphenyl)-3-(5-ethylfuran-2-yl)prop-2-enamide
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- $32 - $275
- Product name: (E)-N-(4-acetylphenyl)-3-(5-ethylfuran-2-yl)prop-2-enamide
- CAS: 890605-54-6
- MF: C17H17NO3
- MW: 283.32
- EINECS:
- MDL Number:MFCD07642957
- Synonyms:(E)-N-(4-acetylphenyl)-3-(5-ethylfuran-2-yl)prop-2-enamide;N-(4-Acetylphenyl)-3-(5-ethyl-2-furanyl)-2-propenamide;2-Propenamide, N-(4-acetylphenyl)-3-(5-ethyl-2-furanyl)-;Heclin >=98% (HPLC);Heclin,E1 activating enzyme,E1/E2/E3 Enzyme,Ubiquitin ligase,E3 ligating enzyme,Ubiquitin conjugating enzyme,E2 conjugating enzyme,Ubiquitin activating enzyme,inhibit,Inhibitor
4 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- TRC
Package
- 1mg
- 5mg
- ManufacturerAK Scientific
- Product number8538CQ
- Product descriptionHeclin
- Packaging1mg
- Price$133
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number26139
- Product descriptionHeclin
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number26139
- Product descriptionHeclin
- Packaging5mg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberH129953
- Product descriptionHeclin
- Packaging5mg
- Price$275
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8538CQ | Heclin | 1mg | $133 | 2021-12-16 | Buy |
| Cayman Chemical | 26139 | Heclin | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 26139 | Heclin | 5mg | $93 | 2024-03-01 | Buy |
| TRC | H129953 | Heclin | 5mg | $275 | 2021-12-16 | Buy |
Properties
storage temp. :-20°C (des.)
solubility :Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
form :solid
color :Beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
solubility :Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
form :solid
color :Beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety Information
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Description
Heclin (890605-54-6) is the first small molecule inhibitor of the HECT domain-containing E3 ubiquitin ligases. Heclin (HECT ligase inhibitor) inhibits several HECT ligases in cultured cells, IC50s = 6.8, 6.3 and 6.9 μM for Smurf2, Nedd4 and WWP1 respectively. It does not block E2 binding but causes a conformational change which results in oxidation of the active site cysteine. Cells tolerate heclin treatment for several hours but exposure for 24 hours leads to death in HEK293 cells, consistent with an essential role for HECT ligase activity in mammalian cells. Heclin does not inhibit RING domain ligases.1?Thus it is a valuable tool for distinguishing between RING and HECT-mediated ubiquitination. Prevents proteasomal degradation of thioredoxin-interacting protein after microbial infection with subsequent reduction of pro-inflammatory mediators.2?Improves short-term memory, consolidation, retrieval and reconsolidation of contextual fear in rodent models.3Related product price
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