H-1152Glycyl, Dihydrochloride
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- $93 - $1274
- Product name: H-1152Glycyl, Dihydrochloride
- CAS: 913844-45-8
- MF: C18H26Cl2N4O3S
- MW: 0
- EINECS:
- MDL Number:MFCD09971082
- Synonyms:(2S)-4-(Aminoacetyl)hexahydro -2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine Dihydrochloride;2-Amino-1-[(3S)-hexahydro-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepin-1-yl]ethanone Hydrochloride;(S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl) sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride;(S)-Glycyl-H-1152 (hydrochloride);Glycyl-H 1152 2HCl;Rho Kinase Inhibitor IV;H-1152Glycyl, Dihydrochloride;Glycyl H-1152 hydrochloride
9 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- Medical Isotopes, Inc.
- TRC
- Usbiological
Package
- 500μg
- 500ug
- 1mg
- 5mg
- 10mg
- ManufacturerAK Scientific
- Product number1779AH
- Product descriptionGlycyl-h1152dihydrochloride
- Packaging1mg
- Price$293
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13332
- Product description(S)-Glycyl-H-1152 (hydrochloride) ≥98%
- Packaging500μg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13332
- Product description(S)-Glycyl-H-1152 (hydrochloride) ≥98%
- Packaging1mg
- Price$176
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13332
- Product description(S)-Glycyl-H-1152 (hydrochloride) ≥98%
- Packaging5mg
- Price$728
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13332
- Product description(S)-Glycyl-H-1152 (hydrochloride) ≥98%
- Packaging10mg
- Price$1274
- Updated2024-03-01
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number10592
- Product descriptionGlycyl-H1152DiHCl
- Packaging500ug
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberH011530
- Product descriptionH-1152GlycylDihydrochloride
- Packaging1mg
- Price$135
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberH011530
- Product descriptionH-1152GlycylDihydrochloride
- Packaging5mg
- Price$575
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number013030
- Product descriptionH-1152 Glycyl Dihydrochloride
- Packaging1mg
- Price$460
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1779AH | Glycyl-h1152dihydrochloride | 1mg | $293 | 2021-12-16 | Buy |
| Cayman Chemical | 13332 | (S)-Glycyl-H-1152 (hydrochloride) ≥98% | 500μg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 13332 | (S)-Glycyl-H-1152 (hydrochloride) ≥98% | 1mg | $176 | 2024-03-01 | Buy |
| Cayman Chemical | 13332 | (S)-Glycyl-H-1152 (hydrochloride) ≥98% | 5mg | $728 | 2024-03-01 | Buy |
| Cayman Chemical | 13332 | (S)-Glycyl-H-1152 (hydrochloride) ≥98% | 10mg | $1274 | 2024-03-01 | Buy |
| Medical Isotopes, Inc. | 10592 | Glycyl-H1152DiHCl | 500ug | $190 | 2021-12-16 | Buy |
| TRC | H011530 | H-1152GlycylDihydrochloride | 1mg | $135 | 2021-12-16 | Buy |
| TRC | H011530 | H-1152GlycylDihydrochloride | 5mg | $575 | 2021-12-16 | Buy |
| Usbiological | 013030 | H-1152 Glycyl Dihydrochloride | 1mg | $460 | 2021-12-16 | Buy |
Properties
Melting point :190-192°C
storage temp. :Refrigerator
solubility :Methanol (Slightly), Water (Slightly)
form :Solid
color :Pale Yellow to Beige
Stability :Hygroscopic
CAS DataBase Reference :913844-45-8
storage temp. :Refrigerator
solubility :Methanol (Slightly), Water (Slightly)
form :Solid
color :Pale Yellow to Beige
Stability :Hygroscopic
CAS DataBase Reference :913844-45-8
Safety Information
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Description
Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits better specificity. Thus, it poorly inhibits Ca2+/calmodulin-dependent kinase type II, protein kinase (PK) G, and Aurora A (IC50 = 2.57, 2.35, and 3.26 μM, respectively) as well as PKA or PKC (IC50 ≥ 10 μM for each). The potency of Glycyl-H-1152 is superior to that of other ROCK inhibitors, including Y-27632 (Ki = 220 nM) and HA-1077 (IC50 = 158 nM).More related product prices
FASUDILRelated product price
- (S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE
$36-560 - FASUDIL
$49-923 - H-1152Glycyl, Dihydrochloride
$93-1274