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ChemicalBook >> CAS DataBase List >> 5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-

5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-

$32 - $2200
Product name: 5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-
CAS: 919486-40-1
MF: C20H20ClN5O2
MW: 397.86
EINECS:
MDL Number:MFCD24038757
Synonyms:5-PyriMidinecarboxaMide, 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]aMino]-4-[(phenylMethyl)aMino]-;AS 1517499;4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide;AS-1517499;AS 1517499;AS-1517499; AS1517499; AS 1517499;919486-40-1;CS-2440;STAT,AS-1517499,inhibit,AS 1517499,AS1517499,Inhibitor

Price23 Properties Safety Information Description

23 prices

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Brand

AK Scientific
Ambeed
American Custom Chemicals Corporation
Axon Medchem
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Sigma-Aldrich

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1mg
5mg
10mg
2x10mg
25mg
50mg
100mg
250mg
1g

ManufacturerAK Scientific
Product number6849CR
Product description4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide
Packaging1mg
Price$133
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number6849CR
Product description4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide
Packaging5mg
Price$226
Updated2021-12-16
Buy

ManufacturerAK Scientific
Product number6849CR
Product description4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide
Packaging10mg
Price$336
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA290303
Product descriptionAS-1517499 95+%
Packaging50mg
Price$264
Updated2021-12-16
Buy

ManufacturerAmerican Custom Chemicals Corporation
Product numberHCH0365462
Product description4-(BENZYLAMINO)-2-((3-CHLORO-4-HYDROXYPHENETHYL)AMINO)PYRIMIDINE-5-CARBOXAMIDE 95.00%
Packaging5MG
Price$499
Updated2021-12-16
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ManufacturerAxon Medchem
Product numberAxon1992
Product descriptionAS1517499 99%
Packaging2x10mg
Price$220
Updated2021-12-16
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ManufacturerCayman Chemical
Product number29071
Product descriptionAS1517499
Packaging1mg
Price$32
Updated2024-03-01
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ManufacturerCayman Chemical
Product number29071
Product descriptionAS1517499
Packaging5mg
Price$116
Updated2024-03-01
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ManufacturerCayman Chemical
Product number29071
Product descriptionAS1517499
Packaging10mg
Price$214
Updated2024-03-01
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ManufacturerCayman Chemical
Product number29071
Product descriptionAS1517499
Packaging25mg
Price$381
Updated2024-03-01
Buy

ManufacturerChemenu
Product numberCM165557
Product description4-(benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide 95%
Packaging100mg
Price$655
Updated2021-12-16
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ManufacturerChemScene
Product numberCS-6099
Product descriptionAS1517499 99.17%
Packaging5mg
Price$144
Updated2021-12-16
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ManufacturerChemScene
Product numberCS-6099
Product descriptionAS1517499 99.17%
Packaging10mg
Price$204
Updated2021-12-16
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ManufacturerChemScene
Product numberCS-6099
Product descriptionAS1517499 99.17%
Packaging25mg
Price$444
Updated2021-12-16
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ManufacturerChemScene
Product numberCS-6099
Product descriptionAS1517499 99.17%
Packaging50mg
Price$780
Updated2021-12-16
Buy

ManufacturerChemScene
Product numberCS-6099
Product descriptionAS1517499 99.17%
Packaging100mg
Price$1200
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
AK Scientific	6849CR	4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide	1mg	$133	2021-12-16	Buy
AK Scientific	6849CR	4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide	5mg	$226	2021-12-16	Buy
AK Scientific	6849CR	4-(Benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide	10mg	$336	2021-12-16	Buy
Ambeed	A290303	AS-1517499 95+%	50mg	$264	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0365462	4-(BENZYLAMINO)-2-((3-CHLORO-4-HYDROXYPHENETHYL)AMINO)PYRIMIDINE-5-CARBOXAMIDE 95.00%	5MG	$499	2021-12-16	Buy
Axon Medchem	Axon1992	AS1517499 99%	2x10mg	$220	2021-12-16	Buy
Cayman Chemical	29071	AS1517499	1mg	$32	2024-03-01	Buy
Cayman Chemical	29071	AS1517499	5mg	$116	2024-03-01	Buy
Cayman Chemical	29071	AS1517499	10mg	$214	2024-03-01	Buy
Cayman Chemical	29071	AS1517499	25mg	$381	2024-03-01	Buy
Chemenu	CM165557	4-(benzylamino)-2-((3-chloro-4-hydroxyphenethyl)amino)pyrimidine-5-carboxamide 95%	100mg	$655	2021-12-16	Buy
ChemScene	CS-6099	AS1517499 99.17%	5mg	$144	2021-12-16	Buy
ChemScene	CS-6099	AS1517499 99.17%	10mg	$204	2021-12-16	Buy
ChemScene	CS-6099	AS1517499 99.17%	25mg	$444	2021-12-16	Buy
ChemScene	CS-6099	AS1517499 99.17%	50mg	$780	2021-12-16	Buy
ChemScene	CS-6099	AS1517499 99.17%	100mg	$1200	2021-12-16	Buy

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Properties

storage temp. :2-8°C
solubility :DMF: 25mg/mL; DMF:PBS (pH 7.2) (1:6): 0.14mg/mL; DMSO: 15mg/mL; Ethanol: 5mg/mL
form :powder
color :white to beige
InChI :InChI=1S/C20H20ClN5O2/c21-16-10-13(6-7-17(16)27)8-9-23-20-25-12-15(18(22)28)19(26-20)24-11-14-4-2-1-3-5-14/h1-7,10,12,27H,8-9,11H2,(H2,22,28)(H2,23,24,25,26)
InChIKey :OZRMEKAUZBKTTC-UHFFFAOYSA-N
SMILES :C1(NCCC2=CC=C(O)C(Cl)=C2)=NC=C(C(N)=O)C(NCC2=CC=CC=C2)=N1

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning		P264, P270, P301+P312, P330, P501

Precautionary statements:

P280	Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

AS1517499 is a STAT6 inhibitor (IC₅₀ = 21 nM in a reporter assay). It inhibits IL-4-induced Th2 differentiation (IC₅₀ = 2.3 nM), but not IL-12-induced Th1 differentiation, of mouse spleen T cells. AS1517499 (10 mg/kg) inhibits bronchial smooth muscle hyperresponsiveness and IL-13 production in ovalbumin-sensitized mice when administered one hour prior to antigen exposure. It inhibits STAT6 phosphorylation and thyroid epithelial cell (TEC) hyperplasia and decreases serum levels of 3,3'',5-triiodo-L-thyronine (T3; ) and thyroxine (T4) in a mouse model of Graves'' disease when administered at a dose of 10 mg/kg per day. AS1517499 (20 mg/kg twice weekly) also inhibits tumor growth and liver metastasis in a murine orthotopic 4T1 mammary carcinoma model.

Suppliers and manufacturers

TargetMol Chemicals Inc.

$34.00 /1mg
AS1517499 CAS:919486-40-1

ATK CHEMICAL COMPANY LIMITED

InvivoChem

Nantong HI-FUTURE Biology Co., Ltd.

TargetMol Chemicals Inc.

LEAPCHEM CO., LTD.

Aladdin Scientific

Amadis Chemical Company Limited BOC Sciences Wuhan TCASChem Technology Co., Ltd.

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