[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl][4-[3-(methylsulfonyl)propyl]-1-piperazinyl]methanone
![[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl][4-[3-(methylsulfonyl)propyl]-1-piperazinyl]methanone price.](/CAS2/GIF/939981-39-2.gif)
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- $57 - $2600
- Product name: [(4R,5S)-4,5-Bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl][4-[3-(methylsulfonyl)propyl]-1-piperazinyl]methanone
- CAS: 939981-39-2
- MF: C38H48Cl2N4O4S
- MW: 727.78
- EINECS:
- MDL Number:MFCD29905459
- Synonyms:[(4R,5S)-4,5-Bis(4-chlorophenyl)-2-[4-(1,1-dimethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-dimethyl-1H-imidazol-1-yl][4-[3-(methylsulfonyl)propyl]-1-piperazinyl]methanone;p53 and MDM2 proteins-interaction-inhibitor;Methanone, [(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-(1,1-diMethylethyl)-2-ethoxyphenyl]-4,5-dihydro-4,5-diMethyl-1H-iMidazol-1-yl][4-[3-(Methylsulfonyl)propyl]-1-piperazinyl]-;p53 inhibitor;RG7112;RG7112;RG 7112;CS-2164;RO5045337 (RG7112)
21 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number4005AH
- Product description((4S,5R)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl)(4-(3-(methylsulfonyl)propyl)piperazin-1-yl)methanone
- Packaging10mg
- Price$586
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004721
- Product description[(4S,5R)-4,5-BIS-(4-CHLOROPHENYL)-2-[4-(1,1-DIMETHYLETHYL)-2-ETHOXYPHENYL]-4,5-DIHYDRO-4,5-DIMETHYL-1H-IMIDAZOL-1-YL]-[4-[3-(METHYLSULFONYL)PROPYL]-1-PIPERAZINYL]METHANONE 95.00%
- Packaging5MG
- Price$504.96
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004721
- Product description[(4S,5R)-4,5-BIS-(4-CHLOROPHENYL)-2-[4-(1,1-DIMETHYLETHYL)-2-ETHOXYPHENYL]-4,5-DIHYDRO-4,5-DIMETHYL-1H-IMIDAZOL-1-YL]-[4-[3-(METHYLSULFONYL)PROPYL]-1-PIPERAZINYL]METHANONE 95.00%
- Packaging10MG
- Price$664.65
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number25673
- Product descriptionRG-7112
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25673
- Product descriptionRG-7112
- Packaging5mg
- Price$233
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25673
- Product descriptionRG-7112
- Packaging10mg
- Price$437
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number25673
- Product descriptionRG-7112
- Packaging25mg
- Price$887
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0330
- Product descriptionRG7112 99.91%
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0330
- Product descriptionRG7112 99.91%
- Packaging10mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0330
- Product descriptionRG7112 99.91%
- Packaging25mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0330
- Product descriptionRG7112 99.91%
- Packaging50mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0330
- Product descriptionRG7112 99.91%
- Packaging100mg
- Price$950
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000158
- Product descriptionRG7112 98+%
- Packaging10mg
- Price$273
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000158
- Product descriptionRG7112 98+%
- Packaging25mg
- Price$579
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000158
- Product descriptionRG7112 98+%
- Packaging50mg
- Price$920
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000158
- Product descriptionRG7112 98+%
- Packaging100mg
- Price$1125
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 4005AH | ((4S,5R)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl)(4-(3-(methylsulfonyl)propyl)piperazin-1-yl)methanone | 10mg | $586 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004721 | [(4S,5R)-4,5-BIS-(4-CHLOROPHENYL)-2-[4-(1,1-DIMETHYLETHYL)-2-ETHOXYPHENYL]-4,5-DIHYDRO-4,5-DIMETHYL-1H-IMIDAZOL-1-YL]-[4-[3-(METHYLSULFONYL)PROPYL]-1-PIPERAZINYL]METHANONE 95.00% | 5MG | $504.96 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004721 | [(4S,5R)-4,5-BIS-(4-CHLOROPHENYL)-2-[4-(1,1-DIMETHYLETHYL)-2-ETHOXYPHENYL]-4,5-DIHYDRO-4,5-DIMETHYL-1H-IMIDAZOL-1-YL]-[4-[3-(METHYLSULFONYL)PROPYL]-1-PIPERAZINYL]METHANONE 95.00% | 10MG | $664.65 | 2021-12-16 | Buy |
| Cayman Chemical | 25673 | RG-7112 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 25673 | RG-7112 | 5mg | $233 | 2024-03-01 | Buy |
| Cayman Chemical | 25673 | RG-7112 | 10mg | $437 | 2024-03-01 | Buy |
| Cayman Chemical | 25673 | RG-7112 | 25mg | $887 | 2024-03-01 | Buy |
| ChemScene | CS-0330 | RG7112 99.91% | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-0330 | RG7112 99.91% | 10mg | $210 | 2021-12-16 | Buy |
| ChemScene | CS-0330 | RG7112 99.91% | 25mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-0330 | RG7112 99.91% | 50mg | $640 | 2021-12-16 | Buy |
| ChemScene | CS-0330 | RG7112 99.91% | 100mg | $950 | 2021-12-16 | Buy |
| Crysdot | CD31000158 | RG7112 98+% | 10mg | $273 | 2021-12-16 | Buy |
| Crysdot | CD31000158 | RG7112 98+% | 25mg | $579 | 2021-12-16 | Buy |
| Crysdot | CD31000158 | RG7112 98+% | 50mg | $920 | 2021-12-16 | Buy |
| Crysdot | CD31000158 | RG7112 98+% | 100mg | $1125 | 2021-12-16 | Buy |
Properties
Density :1.23
storage temp. :Store at -20°C
solubility :≥36.4 mg/mL in DMSO; insoluble in H2O; ≥31.87 mg/mL in EtOH
form :solid
color :White to off-white
storage temp. :Store at -20°C
solubility :≥36.4 mg/mL in DMSO; insoluble in H2O; ≥31.87 mg/mL in EtOH
form :solid
color :White to off-white
Safety Information
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Description
RG-7112 is an inhibitor of mouse double-minute 2 protein (MDM2; IC50 = 0.018 μM), an E3 ubiquitin ligase that ubiquitinates the tumor suppressor p53 and also acts as a negative regulator of p53 transcriptional activity. RG-7112 binds to the p53 binding pocket of MDM2. It increases the levels of p53 and its transcriptional targets in SJSA-1 osteosarcoma cells. It inhibits proliferation in cancer cell lines expressing wild-type p53 (IC50s = 0.18-2.2 μM) and cell lines expressing mutant p53 (IC50s = 5.7-20.3 μM). RG-7112 also prevents and reduces tumor growth in an SJSA-1 mouse xenograft model when administered at doses of 50 and 100 mg/kg per day, respectively. However, it inhibits thrombopoiesis in vivo, decreasing platelet counts in rats when administered at doses of 50 and 100 mg/kg and in cynomolgus monkeys at doses of 10 and 20 mg/kg.Suppliers and manufacturers
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