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ChemicalBook >> CAS DataBase List >> A-83-01

A-83-01

A-83-01 price.
  • $29 - $725
  • Product name: A-83-01
  • CAS: 909910-43-6
  • MF: C25H19N5S
  • MW: 421.52
  • EINECS:
  • MDL Number:MFCD08705403
  • Synonyms:A 83-01;A83-01;TGF inhibitor A-83-01;3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide;TGF-β RI Kinase Inhibitor IV ;A 83-01, >=98%;3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide;A-83-01AB142092);ALK5 Inhibitor IV
21 prices
Selected condition:
Brand
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
Package
  • 1mg
  • 2mg
  • 5mg
  • 10mM(in 1mL DMSO)
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerApexBio Technology
  • Product numberA3133
  • Product descriptionA 83-01
  • Packaging10mM(in 1mL DMSO)
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3133
  • Product descriptionA 83-01
  • Packaging10mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3133
  • Product descriptionA 83-01
  • Packaging50mg
  • Price$405
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBA162484
  • Product descriptionA 83-01
  • Packaging10mg
  • Price$95
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberBA162484
  • Product descriptionA 83-01
  • Packaging50mg
  • Price$332.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number9001799
  • Product descriptionA 83-01 ≥95%
  • Packaging1mg
  • Price$29
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number9001799
  • Product descriptionA 83-01 ≥95%
  • Packaging5mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number9001799
  • Product descriptionA 83-01 ≥95%
  • Packaging10mg
  • Price$99
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number9001799
  • Product descriptionA 83-01 ≥95%
  • Packaging25mg
  • Price$212
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1437
  • Product descriptionA 83-01 ≥98.0%
  • Packaging5mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1437
  • Product descriptionA 83-01 ≥98.0%
  • Packaging10mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1437
  • Product descriptionA 83-01 ≥98.0%
  • Packaging50mg
  • Price$336
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000317
  • Product descriptionA 83-01 98+%
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31000317
  • Product descriptionA 83-01 98+%
  • Packaging50mg
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN13090
  • Product descriptionA 83-01
  • Packaging5mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7286
  • Product descriptionA 83-01 >98%
  • Packaging100mg
  • Price$450
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ApexBio Technology A3133 A 83-01 10mM(in 1mL DMSO) $120 2021-12-16 Buy
ApexBio Technology A3133 A 83-01 10mg $140 2021-12-16 Buy
ApexBio Technology A3133 A 83-01 50mg $405 2021-12-16 Buy
Biosynth Carbosynth BA162484 A 83-01 10mg $95 2021-12-16 Buy
Biosynth Carbosynth BA162484 A 83-01 50mg $332.5 2021-12-16 Buy
Cayman Chemical 9001799 A 83-01 ≥95% 1mg $29 2024-03-01 Buy
Cayman Chemical 9001799 A 83-01 ≥95% 5mg $57 2024-03-01 Buy
Cayman Chemical 9001799 A 83-01 ≥95% 10mg $99 2024-03-01 Buy
Cayman Chemical 9001799 A 83-01 ≥95% 25mg $212 2024-03-01 Buy
ChemScene CS-1437 A 83-01 ≥98.0% 5mg $65 2021-12-16 Buy
ChemScene CS-1437 A 83-01 ≥98.0% 10mg $108 2021-12-16 Buy
ChemScene CS-1437 A 83-01 ≥98.0% 50mg $336 2021-12-16 Buy
Crysdot CD31000317 A 83-01 98+% 10mg $80 2021-12-16 Buy
Crysdot CD31000317 A 83-01 98+% 50mg $260 2021-12-16 Buy
CSNpharm CSN13090 A 83-01 5mg $59 2021-12-16 Buy
DC Chemicals DC7286 A 83-01 >98% 100mg $450 2021-12-16 Buy

Properties

Melting point :111℃
Boiling point :590.0±60.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :8.77±0.70(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

A 83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2?IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ.2?Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency.3?Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts.4?Cell permeable. Active in vivo.