ABC294640
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- $44 - $3728.1
- Product name: ABC294640
- CAS: 915385-81-8
- MF: C23H25ClN2O
- MW: 380.91
- EINECS:
- MDL Number:MFCD22666355
- Synonyms:ABC294640;3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.1(3,7)]decane-1-carboxamide;Tricyclo[3.3.1.13,7]decane-1-carboxamide, 3-(4-chlorophenyl)-N-(4-pyridinylmethyl);ABC294640(Opaganib);3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide;ABC294640; ABC-294640; ABC 294640; 3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE;OPAGANIB;CS-802;ABC294640;ABC-294640;ABC 294640;3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE.
39 prices
Selected condition:
Brand
- Adipogen Life Sciences
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- Crysdot
- CSNpharm
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3749-M025
- Product descriptionOpaganib ≥98%(HPLC)
- Packaging25mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3749-M100
- Product descriptionOpaganib ≥98%(HPLC)
- Packaging100mg
- Price$850
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA110039
- Product descriptionABC294640 98+%
- Packaging1mg
- Price$44
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA110039
- Product descriptionABC294640 98+%
- Packaging5mg
- Price$74
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA110039
- Product descriptionABC294640 98+%
- Packaging10mg
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA110039
- Product descriptionABC294640 98+%
- Packaging50mg
- Price$182
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA110039
- Product descriptionABC294640 98+%
- Packaging100mg
- Price$244
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA110039
- Product descriptionABC294640 98+%
- Packaging250mg
- Price$510
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA110039
- Product descriptionABC294640 98+%
- Packaging1g
- Price$1203
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0017247
- Product descriptionABC-294640 95.00%
- Packaging5MG
- Price$504.17
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0017247
- Product descriptionABC-294640 95.00%
- Packaging250MG
- Price$3067.05
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1182
- Product descriptionABC294640
- Packaging5mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1182
- Product descriptionABC294640
- Packaging25mg
- Price$279
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1182
- Product descriptionABC294640
- Packaging100mg
- Price$685
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS006710
- Product descriptionABC294640 ≥98%
- Packaging1mg
- Price$44
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberAS006710
- Product descriptionABC294640 ≥98%
- Packaging5mg
- Price$73
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Adipogen Life Sciences | AG-CR1-3749-M025 | Opaganib ≥98%(HPLC) | 25mg | $360 | 2021-12-16 | Buy |
Adipogen Life Sciences | AG-CR1-3749-M100 | Opaganib ≥98%(HPLC) | 100mg | $850 | 2021-12-16 | Buy |
Ambeed | A110039 | ABC294640 98+% | 1mg | $44 | 2021-12-16 | Buy |
Ambeed | A110039 | ABC294640 98+% | 5mg | $74 | 2021-12-16 | Buy |
Ambeed | A110039 | ABC294640 98+% | 10mg | $108 | 2021-12-16 | Buy |
Ambeed | A110039 | ABC294640 98+% | 50mg | $182 | 2021-12-16 | Buy |
Ambeed | A110039 | ABC294640 98+% | 100mg | $244 | 2021-12-16 | Buy |
Ambeed | A110039 | ABC294640 98+% | 250mg | $510 | 2021-12-16 | Buy |
Ambeed | A110039 | ABC294640 98+% | 1g | $1203 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0017247 | ABC-294640 95.00% | 5MG | $504.17 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0017247 | ABC-294640 95.00% | 250MG | $3067.05 | 2021-12-16 | Buy |
ApexBio Technology | B1182 | ABC294640 | 5mg | $85 | 2021-12-16 | Buy |
ApexBio Technology | B1182 | ABC294640 | 25mg | $279 | 2021-12-16 | Buy |
ApexBio Technology | B1182 | ABC294640 | 100mg | $685 | 2021-12-16 | Buy |
Arctom | AS006710 | ABC294640 ≥98% | 1mg | $44 | 2021-12-16 | Buy |
Arctom | AS006710 | ABC294640 ≥98% | 5mg | $73 | 2021-12-16 | Buy |
Properties
Boiling point :589.5±50.0 °C(Predicted)
Density :1.273±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :≥38.1 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH
form :solid
pka :14.57±0.40(Predicted)
Density :1.273±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :≥38.1 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH
form :solid
pka :14.57±0.40(Predicted)
Safety Information
Symbol(GHS): |
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Signal word: | Warning | |||||||
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Precautionary statements: |
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Description
ABC294640 is an inhibitor of sphingosine kinase 2 (SPHK2; Ki = 9.8 μM). It inhibits SPHK2 (IC50 = 60 μM) without affecting SPHK1 activity up to 100 μM but does reduce SPHK1 isoform a (SPHK1a) protein levels in androgen-independent LNCaP (LNCaP-AI) cells via an SPHK1-indirect, proteasomal-dependent mechanism when used at concentrations ranging from 5 to 25 μM. ABC294640 is inactive against a panel of 20 lipid-regulated kinases at 50 μM. It decreases sphingosine-1-phosphate (S1P) production in MDA-MB-231 cells in a concentration-dependent manner. ABC294640 inhibits proliferation of a variety of cancer cells, including HepG2 liver, A-498 kidney, PANC-1 pancreas, and HT-29 colon cells (IC50s = 6, 12.2, 32.8, and 48.1 μM, respectively). It reduces actin filament polymerization in, and cell migration of, A-498 cells in a scratch assay. Oral administration of ABC294640 (35 and 100 mg/kg every other day) reduces tumor growth in a mouse syngeneic model of mammary adenocarcinoma. It also reduces colonic inflammation in mouse and rat models of Crohn’s disease induced by trinitrobenzene sulfonic acid (TNBS).More related product prices
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