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ChemicalBook >> CAS DataBase List >> ABC294640

ABC294640

ABC294640 price.
  • $44 - $3728.1
  • Product name: ABC294640
  • CAS: 915385-81-8
  • MF: C23H25ClN2O
  • MW: 380.91
  • EINECS:
  • MDL Number:MFCD22666355
  • Synonyms:ABC294640;3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.1(3,7)]decane-1-carboxamide;Tricyclo[3.3.1.13,7]decane-1-carboxamide, 3-(4-chlorophenyl)-N-(4-pyridinylmethyl);ABC294640(Opaganib);3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide;ABC294640; ABC-294640; ABC 294640; 3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE;OPAGANIB;CS-802;ABC294640;ABC-294640;ABC 294640;3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE.
Price39 Properties Safety Information Description
39 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemenu
  • Crysdot
  • CSNpharm
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3749-M025
  • Product descriptionOpaganib ≥98%(HPLC)
  • Packaging25mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3749-M100
  • Product descriptionOpaganib ≥98%(HPLC)
  • Packaging100mg
  • Price$850
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA110039
  • Product descriptionABC294640 98+%
  • Packaging1mg
  • Price$44
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA110039
  • Product descriptionABC294640 98+%
  • Packaging5mg
  • Price$74
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA110039
  • Product descriptionABC294640 98+%
  • Packaging10mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA110039
  • Product descriptionABC294640 98+%
  • Packaging50mg
  • Price$182
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA110039
  • Product descriptionABC294640 98+%
  • Packaging100mg
  • Price$244
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA110039
  • Product descriptionABC294640 98+%
  • Packaging250mg
  • Price$510
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA110039
  • Product descriptionABC294640 98+%
  • Packaging1g
  • Price$1203
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0017247
  • Product descriptionABC-294640 95.00%
  • Packaging5MG
  • Price$504.17
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0017247
  • Product descriptionABC-294640 95.00%
  • Packaging250MG
  • Price$3067.05
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1182
  • Product descriptionABC294640
  • Packaging5mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1182
  • Product descriptionABC294640
  • Packaging25mg
  • Price$279
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1182
  • Product descriptionABC294640
  • Packaging100mg
  • Price$685
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS006710
  • Product descriptionABC294640 ≥98%
  • Packaging1mg
  • Price$44
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS006710
  • Product descriptionABC294640 ≥98%
  • Packaging5mg
  • Price$73
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences AG-CR1-3749-M025 Opaganib ≥98%(HPLC) 25mg $360 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-3749-M100 Opaganib ≥98%(HPLC) 100mg $850 2021-12-16 Buy
Ambeed A110039 ABC294640 98+% 1mg $44 2021-12-16 Buy
Ambeed A110039 ABC294640 98+% 5mg $74 2021-12-16 Buy
Ambeed A110039 ABC294640 98+% 10mg $108 2021-12-16 Buy
Ambeed A110039 ABC294640 98+% 50mg $182 2021-12-16 Buy
Ambeed A110039 ABC294640 98+% 100mg $244 2021-12-16 Buy
Ambeed A110039 ABC294640 98+% 250mg $510 2021-12-16 Buy
Ambeed A110039 ABC294640 98+% 1g $1203 2021-12-16 Buy
American Custom Chemicals Corporation API0017247 ABC-294640 95.00% 5MG $504.17 2021-12-16 Buy
American Custom Chemicals Corporation API0017247 ABC-294640 95.00% 250MG $3067.05 2021-12-16 Buy
ApexBio Technology B1182 ABC294640 5mg $85 2021-12-16 Buy
ApexBio Technology B1182 ABC294640 25mg $279 2021-12-16 Buy
ApexBio Technology B1182 ABC294640 100mg $685 2021-12-16 Buy
Arctom AS006710 ABC294640 ≥98% 1mg $44 2021-12-16 Buy
Arctom AS006710 ABC294640 ≥98% 5mg $73 2021-12-16 Buy
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Properties

Boiling point :589.5±50.0 °C(Predicted)
Density :1.273±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :≥38.1 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH
form :solid
pka :14.57±0.40(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

ABC294640 is an inhibitor of sphingosine kinase 2 (SPHK2; Ki = 9.8 μM). It inhibits SPHK2 (IC50 = 60 μM) without affecting SPHK1 activity up to 100 μM but does reduce SPHK1 isoform a (SPHK1a) protein levels in androgen-independent LNCaP (LNCaP-AI) cells via an SPHK1-indirect, proteasomal-dependent mechanism when used at concentrations ranging from 5 to 25 μM. ABC294640 is inactive against a panel of 20 lipid-regulated kinases at 50 μM. It decreases sphingosine-1-phosphate (S1P) production in MDA-MB-231 cells in a concentration-dependent manner. ABC294640 inhibits proliferation of a variety of cancer cells, including HepG2 liver, A-498 kidney, PANC-1 pancreas, and HT-29 colon cells (IC50s = 6, 12.2, 32.8, and 48.1 μM, respectively). It reduces actin filament polymerization in, and cell migration of, A-498 cells in a scratch assay. Oral administration of ABC294640 (35 and 100 mg/kg every other day) reduces tumor growth in a mouse syngeneic model of mammary adenocarcinoma. It also reduces colonic inflammation in mouse and rat models of Crohn’s disease induced by trinitrobenzene sulfonic acid (TNBS).

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ABC294640
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ABC294640 CAS:915385-81-8
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