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ChemicalBook >> CAS DataBase List >> AFP 07 (free acid)

AFP 07 (free acid)

AFP 07 (free acid) price.
  • $120 - $952
  • Product name: AFP 07 (free acid)
  • CAS: 788799-13-3
  • MF: C22H30F2O5
  • MW: 412.47
  • EINECS:
  • MDL Number:MFCD00951225
  • Synonyms:AFP 07 (free acid);PVHIRYQSPDZLLG-HBXWYSCUSA-N;AFP07 free acid,AFP 07 free acid;Pentanoic acid, 5-[(3aR,4R,5R,6aS)-3,3-difluorohexahydro-5-hydroxy-4-[(1E,3S,4S)-3-hydroxy-4-methyl-1-nonen-6-ynyl]-2H-cyclopenta[b]furan-2-ylidene]-, (5Z)- (9CI)
4 prices
Selected condition:
Brand
  • AK Scientific
  • Cayman Chemical
Package
  • 500μg
  • 1mg
  • 5mg
  • ManufacturerAK Scientific
  • Product number4011CR
  • Product descriptionAFP-07freeacid
  • Packaging1mg
  • Price$351
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number13626
  • Product descriptionAFP 07 (free acid) ≥98%
  • Packaging500μg
  • Price$120
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13626
  • Product descriptionAFP 07 (free acid) ≥98%
  • Packaging1mg
  • Price$228
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number13626
  • Product descriptionAFP 07 (free acid) ≥98%
  • Packaging5mg
  • Price$952
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 4011CR AFP-07freeacid 1mg $351 2021-12-16 Buy
Cayman Chemical 13626 AFP 07 (free acid) ≥98% 500μg $120 2024-03-01 Buy
Cayman Chemical 13626 AFP 07 (free acid) ≥98% 1mg $228 2024-03-01 Buy
Cayman Chemical 13626 AFP 07 (free acid) ≥98% 5mg $952 2024-03-01 Buy

Properties

Boiling point :557.8±50.0 °C(Predicted)
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 1 mg/ml
pka :4.70±0.10(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM). AFP 07 shows weaker affinity for EP receptors, with Ki values of > 100 nM for EP1-3 and > 10 nM for EP4. In piglet and rabbit saphenous veins, which express both IP and EP4, the EP4 antagonist AH 23848 reduces AFP 07-mediated relaxation, suggesting that AFP 07 activates EP4 as well as IP, particularly when both receptors are present.