AS-041164
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- $58 - $284
- Product name: AS-041164
- CAS: 1146702-72-8
- MF: C11H7NO4S
- MW: 249.24258
- EINECS:
- MDL Number:
- Synonyms:AS-041164
4 prices
Selected condition：
Brand
- Cayman Chemical
Package
- 5mg
- 10mg
- 25mg
- 50mg
- ManufacturerCayman Chemical
- Product number13622
- Product descriptionAS-041164 ≥98%
- Packaging5mg
- Price$58
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13622
- Product descriptionAS-041164 ≥98%
- Packaging10mg
- Price$74
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13622
- Product descriptionAS-041164 ≥98%
- Packaging25mg
- Price$168
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13622
- Product descriptionAS-041164 ≥98%
- Packaging50mg
- Price$284
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 13622 | AS-041164 ≥98% | 5mg | $58 | 2021-12-16 | Buy |
| Cayman Chemical | 13622 | AS-041164 ≥98% | 10mg | $74 | 2021-12-16 | Buy |
| Cayman Chemical | 13622 | AS-041164 ≥98% | 25mg | $168 | 2021-12-16 | Buy |
| Cayman Chemical | 13622 | AS-041164 ≥98% | 50mg | $284 | 2021-12-16 | Buy |
Properties
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Description
The phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.Suppliers and manufacturers
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