AY 9944
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- $34 - $2200
- Product name: AY 9944
- CAS: 366-93-8
- MF: C22H30Cl4N2
- MW: 464.3
- EINECS:
- MDL Number:MFCD01734586
- Synonyms:1,4-cyclohexanebis(methylamine),n,n’-bis(2-chlorobenzyl)-,dihydrochloride,(e ;4-cyclohexanebis(methylamine),n,n’-bis(o-chlorobenzyl)-dihydrochloride ;4-cyclohexanedimethanamine,n,n’-bis((2-chlorophenyl)methyl)-dihydrochlor ;trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexanedihydrochloride ;N-[(2-chlorophenyl)methyl]-1-[4-[[(2-chlorophenyl)methylamino]methyl]cyclohexyl]methanamine dihydrochloride;1,1'-((1r,4r)-cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine);1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE;AY99442HCl
21 prices
Selected condition：
Brand
- Alfa Aesar
- ApexBio Technology
- Biosynth Carbosynth
- Cayman Chemical
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAlfa Aesar
- Product numberJ65079
- Product descriptionAY 9944 dihydrochloride
- Packaging50mg
- Price$896
- Updated2023-06-20
- Buy
- ManufacturerApexBio Technology
- Product numberA8658
- Product descriptionAY 9944 dihydrochloride
- Packaging25mg
- Price$435
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA18037
- Product descriptionAY 9944
- Packaging1mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA18037
- Product descriptionAY 9944
- Packaging5mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA18037
- Product descriptionAY 9944
- Packaging10mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA18037
- Product descriptionAY 9944
- Packaging25mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA18037
- Product descriptionAY 9944
- Packaging50mg
- Price$1250
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14611
- Product descriptionAY 9944 ≥98%
- Packaging1mg
- Price$34
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14611
- Product descriptionAY 9944 ≥98%
- Packaging5mg
- Price$100
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14611
- Product descriptionAY 9944 ≥98%
- Packaging10mg
- Price$183
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14611
- Product descriptionAY 9944 ≥98%
- Packaging25mg
- Price$412
- Updated2024-03-01
- Buy
- ManufacturerCSNpharm
- Product numberCSN22696
- Product descriptionAY99442HCl
- Packaging25mg
- Price$216
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC23895
- Product descriptionAY 9944 >98%
- Packaging100mg
- Price$650
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC23895
- Product descriptionAY 9944 >98%
- Packaging1g
- Price$2200
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product number190080
- Product descriptionAY 9944
- Packaging5mg
- Price$230
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberS693162
- Product description1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE Aldrich
- Packaging5mg
- Price$110
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Alfa Aesar | J65079 | AY 9944 dihydrochloride | 50mg | $896 | 2023-06-20 | Buy |
| ApexBio Technology | A8658 | AY 9944 dihydrochloride | 25mg | $435 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA18037 | AY 9944 | 1mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA18037 | AY 9944 | 5mg | $250 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA18037 | AY 9944 | 10mg | $400 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA18037 | AY 9944 | 25mg | $750 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA18037 | AY 9944 | 50mg | $1250 | 2021-12-16 | Buy |
| Cayman Chemical | 14611 | AY 9944 ≥98% | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 14611 | AY 9944 ≥98% | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 14611 | AY 9944 ≥98% | 10mg | $183 | 2024-03-01 | Buy |
| Cayman Chemical | 14611 | AY 9944 ≥98% | 25mg | $412 | 2024-03-01 | Buy |
| CSNpharm | CSN22696 | AY99442HCl | 25mg | $216 | 2021-12-16 | Buy |
| DC Chemicals | DC23895 | AY 9944 >98% | 100mg | $650 | 2021-12-16 | Buy |
| DC Chemicals | DC23895 | AY 9944 >98% | 1g | $2200 | 2021-12-16 | Buy |
| Sigma-Aldrich | 190080 | AY 9944 | 5mg | $230 | 2024-03-01 | Buy |
| Sigma-Aldrich | S693162 | 1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE Aldrich | 5mg | $110 | 2024-03-01 | Buy |
Properties
Melting point :288-293.5 °C(lit.)
storage temp. :2-8°C
solubility :DMSO: 14 mg/mL
form :White solid
color :white
Water Solubility :Soluble to 50 mM in water
Sensitive :Hygroscopic
storage temp. :2-8°C
solubility :DMSO: 14 mg/mL
form :White solid
color :white
Water Solubility :Soluble to 50 mM in water
Sensitive :Hygroscopic
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
AY 9944 prevents cholesterol biosynthesis by inhibiting the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50 = 13 nM), which interferes with the conversion of 7-dehydro cholesterol to cholesterol. Furthermore, by upregulating the expression of DHCR7, AY 9944 can block Hedgehog signaling at the level of Smoothened or by loss of Suppressor of Fused. AY 9944 inhibition of DHCR7 has been used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome, a disorder brought about by mutations in the DHCR7 gene, in animal models. However, AY 9944 is highly teratogenic, producing congenital defects in offspring when fed to pregnant animals.Related product price
- AY 9944
$34-2200 - 2549-93-1
$16-1309 - 2-Chlorobenzylamine
$10-4312.77
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