AZ 628
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- $25 - $2691.1
- Product name: AZ 628
- CAS: 878739-06-1
- MF: C27H25N5O2
- MW: 451.52
- EINECS:
- MDL Number:MFCD17392577
- Synonyms:3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide;AZ-628;AZ628/AZ-628;AZD628;3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide;AZ628, >=99%;3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)ben;Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-
34 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
Package
- 2mg
- 2.5mg
- 10
- 1mg
- 50
- 10mg
- 10mM(in 1mL DMSO)
- 5MG
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- 1000mg
- ManufacturerAK Scientific
- Product numberY0332
- Product descriptionAZ628
- Packaging1mg
- Price$25
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0388678
- Product description3-(2-CYANOPROPAN-2-YL)-N-(4-METHYL-3-((3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO)PHENYL)BENZAMIDE 95.00%
- Packaging5MG
- Price$502.88
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ628
- Packaging5mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ628
- Packaging10mM(in 1mL DMSO)
- Price$77
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ628
- Packaging10mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ628
- Packaging25mg
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8371
- Product descriptionAZ628
- Packaging50mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0260
- Product descriptionAz628
- Packaging5mg
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0260
- Product descriptionAz628
- Packaging10mg
- Price$167
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0260
- Product descriptionAz628
- Packaging25mg
- Price$327
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60387
- Product descriptionAZ628
- Packaging10mg
- Price$258
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181207
- Product descriptionAZ-628 >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181207
- Product descriptionAZ-628 >98%
- Packaging250mg
- Price$1356.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181207
- Product descriptionAZ-628 >98%
- Packaging1000mg
- Price$2691.1
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC40656
- Product description3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroQuinazolin-6-ylamino)phenyl)benzamide
- Packaging1mg
- Price$50
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFC40656
- Product description3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroQuinazolin-6-ylamino)phenyl)benzamide
- Packaging2mg
- Price$90
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | Y0332 | AZ628 | 1mg | $25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0388678 | 3-(2-CYANOPROPAN-2-YL)-N-(4-METHYL-3-((3-METHYL-4-OXO-3,4-DIHYDROQUINAZOLIN-6-YL)AMINO)PHENYL)BENZAMIDE 95.00% | 5MG | $502.88 | 2021-12-16 | Buy |
| ApexBio Technology | A8371 | AZ628 | 5mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | A8371 | AZ628 | 10mM(in 1mL DMSO) | $77 | 2021-12-16 | Buy |
| ApexBio Technology | A8371 | AZ628 | 10mg | $110 | 2021-12-16 | Buy |
| ApexBio Technology | A8371 | AZ628 | 25mg | $220 | 2021-12-16 | Buy |
| ApexBio Technology | A8371 | AZ628 | 50mg | $360 | 2021-12-16 | Buy |
| Apolloscientific | BISN0260 | Az628 | 5mg | $109 | 2021-12-16 | Buy |
| Apolloscientific | BISN0260 | Az628 | 10mg | $167 | 2021-12-16 | Buy |
| Apolloscientific | BISN0260 | Az628 | 25mg | $327 | 2021-12-16 | Buy |
| Arctom | CFN60387 | AZ628 | 10mg | $258 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181207 | AZ-628 >98% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181207 | AZ-628 >98% | 250mg | $1356.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181207 | AZ-628 >98% | 1000mg | $2691.1 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC40656 | 3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroQuinazolin-6-ylamino)phenyl)benzamide | 1mg | $50 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC40656 | 3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroQuinazolin-6-ylamino)phenyl)benzamide | 2mg | $90 | 2021-12-16 | Buy |
Properties
Density :1.21±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :12.92±0.70(Predicted)
color :white to beige
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :12.92±0.70(Predicted)
color :white to beige
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||||||||||||||||
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Description
The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and other types of cancer but is poorly targeted by many inhibitors of wild type B-Raf. AZ 628 is a quinazilinone that inhibits several Raf kinases, including B-Raf, B-RafV600E, and c-Raf-1 (IC50s = 105, 34, and 29 nM in in vitro kinase assays). It also prevents activation of several tyrosine kinases, including VEGFR2, DDR2, Lyn, Flt1, and FMS. In colon and melanoma cell lines carrying B-RafV600E mutations, AZ 628 is reported to inhibit anchorage-dependent and -independent growth, induce cell cycle arrest, and cause apoptosis.Related product price
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