Atractylenolide-1
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- $45 - $2839
- Product name: Atractylenolide-1
- CAS: 73069-13-3
- MF: C15H18O2
- MW: 230.3
- EINECS:
- MDL Number:MFCD09037395
- Synonyms:ATRACTYLENOLIDE-1;3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one;Eudesma-4(15),7(11),8-trien-12-olide;8,9-Dehydroasterolide;(4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one;Atractylenolide Ⅰ;Atractylenolide I, >99%;Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylene-, (4aS,8aS)-
36 prices
Selected condition:
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
Package
- 5MG
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX1093
- Product descriptionAtractylenolide I
- Packaging10mg
- Price$171
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0006575
- Product descriptionATRACTYLENOLIDE I 95.00%
- Packaging5MG
- Price$314.6
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberN2541
- Product descriptionAtractylenolide I
- Packaging20mg
- Price$365
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN99944
- Product descriptionAtractylenolide I ≥98%
- Packaging20mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number1414
- Product descriptionAtractylenolide I
- Packaging5mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number1414
- Product descriptionAtractylenolide I
- Packaging10mg
- Price$89
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number1414
- Product descriptionAtractylenolide I
- Packaging25mg
- Price$169
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number1414
- Product descriptionAtractylenolide I
- Packaging100mg
- Price$369
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number1414
- Product descriptionAtractylenolide I
- Packaging250mg
- Price$779
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number1414
- Product descriptionAtractylenolide I
- Packaging1g
- Price$2290
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb573063
- Product descriptionAtractylenolide 1 >98%,Standard References Grade
- Packaging100mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb573063
- Product descriptionAtractylenolide 1 >98%,Standard References Grade
- Packaging250mg
- Price$1654.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb573063
- Product descriptionAtractylenolide 1 >98%,Standard References Grade
- Packaging1g
- Price$2839
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA73867
- Product descriptionAtractylenolide I
- Packaging5mg
- Price$52
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA73867
- Product descriptionAtractylenolide I
- Packaging10mg
- Price$90
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFA73867
- Product descriptionAtractylenolide I
- Packaging25mg
- Price$180
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | X1093 | Atractylenolide I | 10mg | $171 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0006575 | ATRACTYLENOLIDE I 95.00% | 5MG | $314.6 | 2021-12-16 | Buy |
ApexBio Technology | N2541 | Atractylenolide I | 20mg | $365 | 2021-12-16 | Buy |
Arctom | CFN99944 | Atractylenolide I ≥98% | 20mg | $118 | 2021-12-16 | Buy |
AvaChem | 1414 | Atractylenolide I | 5mg | $49 | 2021-12-16 | Buy |
AvaChem | 1414 | Atractylenolide I | 10mg | $89 | 2021-12-16 | Buy |
AvaChem | 1414 | Atractylenolide I | 25mg | $169 | 2021-12-16 | Buy |
AvaChem | 1414 | Atractylenolide I | 100mg | $369 | 2021-12-16 | Buy |
AvaChem | 1414 | Atractylenolide I | 250mg | $779 | 2021-12-16 | Buy |
AvaChem | 1414 | Atractylenolide I | 1g | $2290 | 2021-12-16 | Buy |
Biorbyt Ltd | orb573063 | Atractylenolide 1 >98%,Standard References Grade | 100mg | $912.9 | 2021-12-16 | Buy |
Biorbyt Ltd | orb573063 | Atractylenolide 1 >98%,Standard References Grade | 250mg | $1654.1 | 2021-12-16 | Buy |
Biorbyt Ltd | orb573063 | Atractylenolide 1 >98%,Standard References Grade | 1g | $2839 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA73867 | Atractylenolide I | 5mg | $52 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA73867 | Atractylenolide I | 10mg | $90 | 2021-12-16 | Buy |
Biosynth Carbosynth | FA73867 | Atractylenolide I | 25mg | $180 | 2021-12-16 | Buy |
Properties
Melting point :121-123 °C(Solv: ligroine (8032-32-4))
Boiling point :405.0±44.0 °C(Predicted)
Density :1.12
Flash point :170℃
storage temp. :2-8°C
solubility :methanol: soluble1mg/mL, clear, colorless
form :powder
color :White
InChIKey :ZTVSGQPHMUYCRS-SWLSCSKDSA-N
Boiling point :405.0±44.0 °C(Predicted)
Density :1.12
Flash point :170℃
storage temp. :2-8°C
solubility :methanol: soluble1mg/mL, clear, colorless
form :powder
color :White
InChIKey :ZTVSGQPHMUYCRS-SWLSCSKDSA-N
Safety Information
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Description
Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively). Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA). It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; ) and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.More related product prices
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