BAY-1125976.
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- $32 - $2200
- Product name: BAY-1125976.
- CAS: 1402608-02-9
- MF: C23H21N5O
- MW: 383.45
- EINECS:
- MDL Number:MFCD30481340
- Synonyms:BAY 1125976;BAY1125976;BAY-1125976.;2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide;BAY-1125976; BAY 1125976;CS-2913;Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl-;inhibit,Inhibitor,Protein kinase B,Akt,BAY 1125976,BAY1125976,PKB,BAY-1125976
16 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number2002DU
- Product description2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide
- Packaging5mg
- Price$252
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number28913
- Product descriptionBAY-1125976
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28913
- Product descriptionBAY-1125976
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28913
- Product descriptionBAY-1125976
- Packaging10mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28913
- Product descriptionBAY-1125976
- Packaging25mg
- Price$533
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-6212
- Product descriptionBAY1125976 99.86%
- Packaging2mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6212
- Product descriptionBAY1125976 99.86%
- Packaging5mg
- Price$216
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6212
- Product descriptionBAY1125976 99.86%
- Packaging10mg
- Price$336
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6212
- Product descriptionBAY1125976 99.86%
- Packaging50mg
- Price$696
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6212
- Product descriptionBAY1125976 99.86%
- Packaging100mg
- Price$1176
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD00009968
- Product descriptionBAY1125976 97%
- Packaging5mg
- Price$125
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD00009968
- Product descriptionBAY1125976 97%
- Packaging10mg
- Price$194
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD00009968
- Product descriptionBAY1125976 97%
- Packaging50mg
- Price$402
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD00009968
- Product descriptionBAY1125976 97%
- Packaging100mg
- Price$679
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10408
- Product descriptionBAY1125976 >98%
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC10408
- Product descriptionBAY1125976 >98%
- Packaging1g
- Price$2200
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2002DU | 2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazine-6-carboxamide | 5mg | $252 | 2021-12-16 | Buy |
| Cayman Chemical | 28913 | BAY-1125976 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 28913 | BAY-1125976 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 28913 | BAY-1125976 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 28913 | BAY-1125976 | 25mg | $533 | 2024-03-01 | Buy |
| ChemScene | CS-6212 | BAY1125976 99.86% | 2mg | $132 | 2021-12-16 | Buy |
| ChemScene | CS-6212 | BAY1125976 99.86% | 5mg | $216 | 2021-12-16 | Buy |
| ChemScene | CS-6212 | BAY1125976 99.86% | 10mg | $336 | 2021-12-16 | Buy |
| ChemScene | CS-6212 | BAY1125976 99.86% | 50mg | $696 | 2021-12-16 | Buy |
| ChemScene | CS-6212 | BAY1125976 99.86% | 100mg | $1176 | 2021-12-16 | Buy |
| Crysdot | CD00009968 | BAY1125976 97% | 5mg | $125 | 2021-12-16 | Buy |
| Crysdot | CD00009968 | BAY1125976 97% | 10mg | $194 | 2021-12-16 | Buy |
| Crysdot | CD00009968 | BAY1125976 97% | 50mg | $402 | 2021-12-16 | Buy |
| Crysdot | CD00009968 | BAY1125976 97% | 100mg | $679 | 2021-12-16 | Buy |
| DC Chemicals | DC10408 | BAY1125976 >98% | 100mg | $550 | 2021-12-16 | Buy |
| DC Chemicals | DC10408 | BAY1125976 >98% | 1g | $2200 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMSO:13.0(Max Conc. mg/mL);33.9(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);13.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.65(Max Conc. mM) form :A crystalline solid
color :Light yellow to yellow
solubility :DMSO:13.0(Max Conc. mg/mL);33.9(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);13.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.65(Max Conc. mM) form :A crystalline solid
color :Light yellow to yellow
Safety Information
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Description
BAY-1125976 is an allosteric inhibitor of Akt1 and -2 (IC50s = 5.2 and 18 nM, respectively, in a time-resolved FRET assay). It is selective for Akt1 and -2 over Akt3 (IC50 = 427 nM in the same assay) but does inhibit the activity of the receptor tyrosine kinases FLT1, -3, -4, and Mer by greater than 50% in a panel of 227 kinases at 1 μM. BAY-1125976 inhibits the proliferation of 23 cancer cell lines (IC50s = 0.02-10 μM) and reduces tumor growth in KPL-4, MCF-7, and patient-derived xenograft (PDX) mouse models when administered at a dose of 50 mg/kg per day.Suppliers and manufacturers
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