BH3I-1
|
- $44 - $1350
- Product name: BH3I-1
- CAS: 300817-68-9
- MF: C15H14BrNO3S2
- MW: 400.31
- EINECS:
- MDL Number:MFCD03453544
- Synonyms:5-(p-Bromobenzylidine)-α-isopropyl-4-oxo-2-thioxo-3-thiozolidineacetic acid;BH3I 1 ;BH3I1;BHI1;BHI1;BH 3I1;3-Thiazolidineacetic acid, 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo-;5-(p-Bromobenzylidene)-a-isopropyl-4-oxo-2-thioxo-3-thiazolidine acetic acid;2-(5-(4-Bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-methylbutanoic acid;MDM-2/p53,BH3I 1,Inhibitor,Ubiquitin ligase,BH3I-1,E3 ligating enzyme,Ubiquitin conjugating enzyme,BH3I1,E2 conjugating enzyme,Bcl-2 Family,BHI 1,E1 activating enzyme,inhibit,BHI-1,BH 3I1,E1/E2/E3 Enzyme,Ubiquitin activating enzyme,BH-3I-1
25 prices
Selected condition：
Brand
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAmbeed
- Product numberA189286
- Product descriptionBH3I-1 98+%
- Packaging5mg
- Price$118
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189286
- Product descriptionBH3I-1 98+%
- Packaging10mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189286
- Product descriptionBH3I-1 98+%
- Packaging25mg
- Price$340
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA189286
- Product descriptionBH3I-1 98+%
- Packaging50mg
- Price$442
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0008455
- Product descriptionBH3I-1 95.00%
- Packaging5MG
- Price$750.87
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6094
- Product descriptionBH3I-1
- Packaging2mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6094
- Product descriptionBH3I-1
- Packaging25mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18763
- Product descriptionBH3I-1 ≥95%
- Packaging1mg
- Price$44
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18763
- Product descriptionBH3I-1 ≥95%
- Packaging5mg
- Price$183
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18763
- Product descriptionBH3I-1 ≥95%
- Packaging10mg
- Price$321
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18763
- Product descriptionBH3I-1 ≥95%
- Packaging25mg
- Price$692
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM252035
- Product descriptionBH3I-1 98%
- Packaging50mg
- Price$449
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5730
- Product descriptionBH3I-1 >98.0%
- Packaging2mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5730
- Product descriptionBH3I-1 >98.0%
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5730
- Product descriptionBH3I-1 >98.0%
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-5730
- Product descriptionBH3I-1 >98.0%
- Packaging25mg
- Price$300
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Ambeed | A189286 | BH3I-1 98+% | 5mg | $118 | 2021-12-16 | Buy |
| Ambeed | A189286 | BH3I-1 98+% | 10mg | $200 | 2021-12-16 | Buy |
| Ambeed | A189286 | BH3I-1 98+% | 25mg | $340 | 2021-12-16 | Buy |
| Ambeed | A189286 | BH3I-1 98+% | 50mg | $442 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008455 | BH3I-1 95.00% | 5MG | $750.87 | 2021-12-16 | Buy |
| ApexBio Technology | B6094 | BH3I-1 | 2mg | $65 | 2021-12-16 | Buy |
| ApexBio Technology | B6094 | BH3I-1 | 25mg | $330 | 2021-12-16 | Buy |
| Cayman Chemical | 18763 | BH3I-1 ≥95% | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18763 | BH3I-1 ≥95% | 5mg | $183 | 2024-03-01 | Buy |
| Cayman Chemical | 18763 | BH3I-1 ≥95% | 10mg | $321 | 2024-03-01 | Buy |
| Cayman Chemical | 18763 | BH3I-1 ≥95% | 25mg | $692 | 2024-03-01 | Buy |
| Chemenu | CM252035 | BH3I-1 98% | 50mg | $449 | 2021-12-16 | Buy |
| ChemScene | CS-5730 | BH3I-1 >98.0% | 2mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-5730 | BH3I-1 >98.0% | 5mg | $95 | 2021-12-16 | Buy |
| ChemScene | CS-5730 | BH3I-1 >98.0% | 10mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-5730 | BH3I-1 >98.0% | 25mg | $300 | 2021-12-16 | Buy |
Properties
Boiling point :535.2±60.0 °C(Predicted)
Density :1?+-.0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: >10 mg/mL, soluble
form :powder, yellow
pka :3.39±0.10(Predicted)
color :Light yellow to yellow
Density :1?+-.0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: >10 mg/mL, soluble
form :powder, yellow
pka :3.39±0.10(Predicted)
color :Light yellow to yellow
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||
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Description
The family of Bcl-2 proteins plays pivotal roles in either promoting or preventing apoptosis. Bcl-2 family members contain one or more of four characteristic Bcl-2 homology (BH) domains, which are crucial for function. For example, anti-apoptotic Bcl-2 family proteins prevent death signaling by heterodimerizing with pro-death proteins at their BH3 domains. BH3I-1 is a cell permeable inhibitor that blocks the binding of BH3 peptides to Bcl-xL, inducing apoptosis. It inhibits interactions of BH3 domain-containing proteins with Bcl-xL, Bcl-2, and Bcl-W, inducing apoptosis in Bcl-2 or Bcl-W expressing cells with Ki values of 43.4 and 124 μM, respectively. BH3I-1 enhances radiation sensitivity in non-small cell lung cancer cells.Suppliers and manufacturers
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InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
Amadis Chemical Company Limited
