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ChemicalBook >> CAS DataBase List >> BI-847325

BI-847325

BI-847325 price.
  • $73 - $1800
  • Product name: BI-847325
  • CAS: 1207293-36-4
  • MF: C29H28N4O2
  • MW: 464.56
  • EINECS:-0
  • MDL Number:MFCD28978743
  • Synonyms:BI-847325;3-[3-[[[4-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-2-propynamide;BI-847325, 98%, an ATP competitive dual inhibitor of MEK and aurora kinases (AK);3-[3-[[4-(dimethylaminomethyl)anilino]-phenylmethylidene]-2-oxo-1H-indol-6-yl]-N-ethylprop-2-ynamide;BI 847325;BI847325;BI-847325;BI 847325;BI847325;(Z)-3-(3-(((4-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide;2-Propynamide, 3-[3-[[[4-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-
Price23 Properties Safety Information Description
23 prices
Selected condition：
Brand
  • Activate Scientific
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • ManufacturerActivate Scientific
  • Product numberAS116436
  • Product descriptionBI-847325 99+%
  • Packaging1mg
  • Price$113
  • Updated2021-12-16
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS116436
  • Product descriptionBI-847325 99+%
  • Packaging5mg
  • Price$198
  • Updated2021-12-16
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS116436
  • Product descriptionBI-847325 99+%
  • Packaging25mg
  • Price$575
  • Updated2021-12-16
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS116436
  • Product descriptionBI-847325 99+%
  • Packaging100mg
  • Price$1203
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3237EM
  • Product description3-[3-[N-[4-[(Dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-1H-indol-6-yl]-N-ethylprop-2-ynamide
  • Packaging1mg
  • Price$179
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0005692
  • Product descriptionBI-847325 95.00%
  • Packaging5MG
  • Price$497.76
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6014
  • Product descriptionBI-847325
  • Packaging5mg
  • Price$173
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6014
  • Product descriptionBI-847325
  • Packaging10mg
  • Price$284
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6014
  • Product descriptionBI-847325
  • Packaging25mg
  • Price$551
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6014
  • Product descriptionBI-847325
  • Packaging50mg
  • Price$914
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6014
  • Product descriptionBI-847325
  • Packaging100mg
  • Price$1229
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18301
  • Product descriptionBI-847325 ≥98%
  • Packaging1mg
  • Price$73
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18301
  • Product descriptionBI-847325 ≥98%
  • Packaging5mg
  • Price$171
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6291
  • Product descriptionBI-847325 99.14%
  • Packaging5mg
  • Price$132
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6291
  • Product descriptionBI-847325 99.14%
  • Packaging10mg
  • Price$216
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6291
  • Product descriptionBI-847325 99.14%
  • Packaging25mg
  • Price$432
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Activate Scientific AS116436 BI-847325 99+% 1mg $113 2021-12-16 Buy
Activate Scientific AS116436 BI-847325 99+% 5mg $198 2021-12-16 Buy
Activate Scientific AS116436 BI-847325 99+% 25mg $575 2021-12-16 Buy
Activate Scientific AS116436 BI-847325 99+% 100mg $1203 2021-12-16 Buy
AK Scientific 3237EM 3-[3-[N-[4-[(Dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-1H-indol-6-yl]-N-ethylprop-2-ynamide 1mg $179 2021-12-16 Buy
American Custom Chemicals Corporation INB0005692 BI-847325 95.00% 5MG $497.76 2021-12-16 Buy
ApexBio Technology B6014 BI-847325 5mg $173 2021-12-16 Buy
ApexBio Technology B6014 BI-847325 10mg $284 2021-12-16 Buy
ApexBio Technology B6014 BI-847325 25mg $551 2021-12-16 Buy
ApexBio Technology B6014 BI-847325 50mg $914 2021-12-16 Buy
ApexBio Technology B6014 BI-847325 100mg $1229 2021-12-16 Buy
Cayman Chemical 18301 BI-847325 ≥98% 1mg $73 2024-03-01 Buy
Cayman Chemical 18301 BI-847325 ≥98% 5mg $171 2024-03-01 Buy
ChemScene CS-6291 BI-847325 99.14% 5mg $132 2021-12-16 Buy
ChemScene CS-6291 BI-847325 99.14% 10mg $216 2021-12-16 Buy
ChemScene CS-6291 BI-847325 99.14% 25mg $432 2021-12-16 Buy
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Properties

storage temp. :Store at -20°C
solubility :≥24.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
form :crystalline solid
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

BI-847325 is a selective dual MEK/Aurora kinase inhibitor with IC50 values of 3, 25, 15, 25, and 4 nM for X. laevis Aurora B, human Aurora A and Aurora C, and human MEK1 and MEK2, respectively. It can inhibit the growth and survival of both treatment-naive and drug-resistant melanoma cell lines, decreasing the expression of MEK and Mcl-1 while increasing the expression of pro-apoptotic protein Bim. At 70 mg/kg, BI-847325 induces apoptosis in treatment-naive and drug-resistant xenografted melanoma in vivo.

Suppliers and manufacturers

ATK CHEMICAL COMPANY LIMITED
BOC Sciences
Career Henan Chemica Co
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Finetech Industry Limited
Hefei Hirisun Pharmatech Co., Ltd
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.