BI 882370
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- $32 - $1900
- Product name: BI 882370
- CAS: 1392429-79-6
- MF: C28H33F2N7O2S
- MW: 569.67
- EINECS:-0
- MDL Number:MFCD31618072
- Synonyms:BI 882370;BI882370;BI-882370;1-Propanesulfonamide, N-[3-[5-[(1-ethyl-4-piperidinyl)methylamino]-3-(5-pyrimidinyl)-1H-pyrrolo[3,2-b]pyridin-1-yl]-2,4-difluorophenyl]-;CS-2615;BI-882370,Raf,BI882370,inhibit,Inhibitor,Raf kinases,BI 882370;N-(3-(5-((1-Ethylpiperidin-4-yl)(methyl)amino)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-2,4-difluorophenyl)propane-1-sulfonamide
11 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1g
- ManufacturerAK Scientific
- Product number8525DP
- Product descriptionCID60152613
- Packaging10mg
- Price$370
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number8525DP
- Product descriptionCID60152613
- Packaging25mg
- Price$691
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number24273
- Product descriptionBI-882370 ≥95%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24273
- Product descriptionBI-882370 ≥95%
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24273
- Product descriptionBI-882370 ≥95%
- Packaging10mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24273
- Product descriptionBI-882370 ≥95%
- Packaging25mg
- Price$533
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0030522
- Product descriptionBI-882370 99.16%
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0030522
- Product descriptionBI-882370 99.16%
- Packaging10mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0030522
- Product descriptionBI-882370 99.16%
- Packaging50mg
- Price$550
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0030522
- Product descriptionBI-882370 99.16%
- Packaging100mg
- Price$970
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC23817
- Product descriptionBI882370 >98%
- Packaging1g
- Price$1900
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 8525DP | CID60152613 | 10mg | $370 | 2021-12-16 | Buy |
| AK Scientific | 8525DP | CID60152613 | 25mg | $691 | 2021-12-16 | Buy |
| Cayman Chemical | 24273 | BI-882370 ≥95% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 24273 | BI-882370 ≥95% | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 24273 | BI-882370 ≥95% | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 24273 | BI-882370 ≥95% | 25mg | $533 | 2024-03-01 | Buy |
| ChemScene | CS-0030522 | BI-882370 99.16% | 5mg | $95 | 2021-12-16 | Buy |
| ChemScene | CS-0030522 | BI-882370 99.16% | 10mg | $170 | 2021-12-16 | Buy |
| ChemScene | CS-0030522 | BI-882370 99.16% | 50mg | $550 | 2021-12-16 | Buy |
| ChemScene | CS-0030522 | BI-882370 99.16% | 100mg | $970 | 2021-12-16 | Buy |
| DC Chemicals | DC23817 | BI882370 >98% | 1g | $1900 | 2021-12-16 | Buy |
Properties
Boiling point :649.6±65.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:5.0(Max Conc. mg/mL);8.78(Max Conc. mM)
form :A crystalline solid
pka :5.48±0.10(Predicted)
color :Off-white to gray
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:5.0(Max Conc. mg/mL);8.78(Max Conc. mM)
form :A crystalline solid
pka :5.48±0.10(Predicted)
color :Off-white to gray
Safety Information
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Description
BI-882370 is an orally bioavailable RAF inhibitor with IC50 values of 0.8, 0.8, and 0.6 nM for B-RAFV600E, wild-type B-RAF, and C-RAF in the DFG-out inactive conformation, respectively. It is selective for RAF over a panel of kinases, including LCK, KIT, Src, LYNA, LYNB, and PDGFR (IC50s = 49, 415, 485, 750, 715, and 1,220 nM, respectively). It inhibits proliferation of human B-RAF-mutant melanoma cells when used at concentrations ranging from 1 to 10 nM. It reduces tumor growth in multiple B-RAF-mutant melanoma and colorectal carcinoma mouse xenograft models when administered at a dose of 25 mg/kg twice per day. BI-882370, alone and in combination with trametinib , induces tumor regression in an A375 melanoma mouse xenograft model with no resistance developing within three or five weeks, respectively.Suppliers and manufacturers
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