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ChemicalBook >> CAS DataBase List >> BIX02189

BIX02189

BIX02189 price.
  • $45 - $3136.5
  • Product name: BIX02189
  • CAS: 1265916-41-3
  • MF: C27H28N4O2
  • MW: 440.54
  • EINECS:
  • MDL Number:MFCD18074528
  • Synonyms:(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide;(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-c;BIX02189 (BIX 02189);1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-, (3Z)-;Mitogen-activated protein kinase kinase,inhibit,MAP2K,MAPKK,MEK,BIX02189,Extracellular signal regulated kinases,Inhibitor,ERK,BIX-02189;BIX02189(d)
26 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • Apolloscientific
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberSYN5426
  • Product descriptionBIX-02189
  • Packaging10mg
  • Price$217
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5426
  • Product descriptionBIX-02189
  • Packaging50mg
  • Price$757
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA511821
  • Product descriptionBix-02189 98+%
  • Packaging50mg
  • Price$669
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0255
  • Product descriptionBix-02189
  • Packaging1mg
  • Price$66
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0255
  • Product descriptionBix-02189
  • Packaging10mg
  • Price$174
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0255
  • Product descriptionBix-02189
  • Packaging50mg
  • Price$573
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154721
  • Product descriptionBIX02189 (BIX 02189) >98%
  • Packaging100mg
  • Price$838.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154721
  • Product descriptionBIX02189 (BIX 02189) >98%
  • Packaging250mg
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154721
  • Product descriptionBIX02189 (BIX 02189) >98%
  • Packaging1g
  • Price$3136.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB137657
  • Product descriptionBIX 02189
  • Packaging10mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB137657
  • Product descriptionBIX 02189
  • Packaging50mg
  • Price$472.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16999
  • Product descriptionBIX02189 ≥98%
  • Packaging5mg
  • Price$117
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16999
  • Product descriptionBIX02189 ≥98%
  • Packaging10mg
  • Price$210
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16999
  • Product descriptionBIX02189 ≥98%
  • Packaging25mg
  • Price$290
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16999
  • Product descriptionBIX02189 ≥98%
  • Packaging50mg
  • Price$760
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0215
  • Product descriptionBIX02189 99.99%
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5426 BIX-02189 10mg $217 2021-12-16 Buy
AK Scientific SYN5426 BIX-02189 50mg $757 2021-12-16 Buy
Ambeed A511821 Bix-02189 98+% 50mg $669 2021-12-16 Buy
Apolloscientific BISN0255 Bix-02189 1mg $66 2021-12-16 Buy
Apolloscientific BISN0255 Bix-02189 10mg $174 2021-12-16 Buy
Apolloscientific BISN0255 Bix-02189 50mg $573 2021-12-16 Buy
Biorbyt Ltd orb154721 BIX02189 (BIX 02189) >98% 100mg $838.1 2021-12-16 Buy
Biorbyt Ltd orb154721 BIX02189 (BIX 02189) >98% 250mg $1802 2021-12-16 Buy
Biorbyt Ltd orb154721 BIX02189 (BIX 02189) >98% 1g $3136.5 2021-12-16 Buy
Biosynth Carbosynth FB137657 BIX 02189 10mg $135 2021-12-16 Buy
Biosynth Carbosynth FB137657 BIX 02189 50mg $472.5 2021-12-16 Buy
Cayman Chemical 16999 BIX02189 ≥98% 5mg $117 2024-03-01 Buy
Cayman Chemical 16999 BIX02189 ≥98% 10mg $210 2024-03-01 Buy
Cayman Chemical 16999 BIX02189 ≥98% 25mg $290 2024-03-01 Buy
Cayman Chemical 16999 BIX02189 ≥98% 50mg $760 2021-12-16 Buy
ChemScene CS-0215 BIX02189 99.99% 5mg $90 2021-12-16 Buy

Properties

Boiling point :653.4±55.0 °C(Predicted)
Density :1.230±0.06 g/cm3(Predicted)
storage temp. :2-8°C(protect from light)
solubility :DMSO:34.48(Max Conc. mg/mL);78.27(Max Conc. mM)
DMF:15.0(Max Conc. mg/mL);34.05(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.13(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);22.7(Max Conc. mM) form :A crystalline solid
pka :11.61±0.20(Predicted)
color :White to yellow

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P370+P378 In case of fire: Use … for extinction.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

MEK5, also known as MAP2K5, phosphorylates ERK5 (MAPK7) in signaling pathways involved in stress-induced apoptosis, neuronal survival, cardiac development, and angiogenesis. BIX02189 is a potent inhibitor of both MEK5 and ERK5 (IC50s = 1.5 and 59 nM, respectively), preventing transcriptional activation of the downstream target MEF2C. It minimally inhibits a panel of related kinases, including MEK1/2 and ERK1/2. BIX02189 blocks sorbitol-induced phosphorylation of ERK5, without affecting phosphorylation of ERK1/2, in HeLa cells. It has been used to investigate the roles of MEK5/ERK5 signaling in nerve growth factor-mediated neurite outgrowth and myeloid cell differentiation.