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ChemicalBook >> CAS DataBase List >> BRL 50481

BRL 50481

BRL 50481 price.
  • $34 - $2691.1
  • Product name: BRL 50481
  • CAS: 433695-36-4
  • MF: C9H12N2O4S
  • MW: 244.27
  • EINECS:1592732-453-0
  • MDL Number:MFCD03039912
  • Synonyms:5-NITRO-2,N,N-TRIMETHYLBENZENESULFONAMIDE;BRL 50481;N,N,2-TRIMETHYL-5-NITRO-BENZENESULFONAMIDE;3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene,5-Nitro-2-N,N-trimethylbenzenesulfonamide;Benzenesulfonamide, N,N,2-trimethyl-5-nitro-;-50481
42 prices
Selected condition:
Brand
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 50
  • 100mg
  • 200MG
  • 250mg
  • 500mg
  • 1g
  • ManufacturerAK Scientific
  • Product number4516CJ
  • Product descriptionN,N,2-Trimethyl-5-nitrobenzenesulfonamide
  • Packaging100mg
  • Price$212
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ67146
  • Product descriptionBRL-50481, 98%
  • Packaging10mg
  • Price$122
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024926
  • Product descriptionBRL 50481 95.00%
  • Packaging100MG
  • Price$1593.9
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6988
  • Product descriptionBRL 50481
  • Packaging5mg
  • Price$79
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6988
  • Product descriptionBRL 50481
  • Packaging10mg
  • Price$103
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6988
  • Product descriptionBRL 50481
  • Packaging25mg
  • Price$205
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6988
  • Product descriptionBRL 50481
  • Packaging50mg
  • Price$347
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6988
  • Product descriptionBRL 50481
  • Packaging100mg
  • Price$567
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573365
  • Product descriptionBRL 50481 >98%
  • Packaging100mg
  • Price$690.2
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573365
  • Product descriptionBRL 50481 >98%
  • Packaging250mg
  • Price$1356.6
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb573365
  • Product descriptionBRL 50481 >98%
  • Packaging1g
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB19012
  • Product descriptionBRL 50481
  • Packaging25mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB19012
  • Product descriptionBRL 50481
  • Packaging50mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB19012
  • Product descriptionBRL 50481
  • Packaging100mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB19012
  • Product descriptionBRL 50481
  • Packaging250mg
  • Price$180
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFB19012
  • Product descriptionBRL 50481
  • Packaging500mg
  • Price$275
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 4516CJ N,N,2-Trimethyl-5-nitrobenzenesulfonamide 100mg $212 2021-12-16 Buy
Alfa Aesar J67146 BRL-50481, 98% 10mg $122 2021-12-16 Buy
American Custom Chemicals Corporation API0024926 BRL 50481 95.00% 100MG $1593.9 2021-12-16 Buy
ApexBio Technology B6988 BRL 50481 5mg $79 2021-12-16 Buy
ApexBio Technology B6988 BRL 50481 10mg $103 2021-12-16 Buy
ApexBio Technology B6988 BRL 50481 25mg $205 2021-12-16 Buy
ApexBio Technology B6988 BRL 50481 50mg $347 2021-12-16 Buy
ApexBio Technology B6988 BRL 50481 100mg $567 2021-12-16 Buy
Biorbyt Ltd orb573365 BRL 50481 >98% 100mg $690.2 2021-12-16 Buy
Biorbyt Ltd orb573365 BRL 50481 >98% 250mg $1356.6 2021-12-16 Buy
Biorbyt Ltd orb573365 BRL 50481 >98% 1g $2691.1 2021-12-16 Buy
Biosynth Carbosynth FB19012 BRL 50481 25mg $50 2021-12-16 Buy
Biosynth Carbosynth FB19012 BRL 50481 50mg $80 2021-12-16 Buy
Biosynth Carbosynth FB19012 BRL 50481 100mg $120 2021-12-16 Buy
Biosynth Carbosynth FB19012 BRL 50481 250mg $180 2021-12-16 Buy
Biosynth Carbosynth FB19012 BRL 50481 500mg $275 2021-12-16 Buy

Properties

Melting point :65-67°C
Boiling point :391.1±52.0 °C(Predicted)
Density :1.334±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 12 mg/mL
form :solid
pka :-5?+-.0.70(Predicted)
color :white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

BRL 50481 is a potent, selective inhibitor of phosphodiesterase (PDE) 7, inhibiting human recombinant PDE7A1 with a Ki value of 180 nM. It is much less effective against PDE3 and PDE4 and is without effect against PDE1B, PDE1C, PDE2, and PDE5. Through its effects on PDE7A1, BRL 50481 enhances the inhibitory effects of the PDE4 blocker rolipram on monocytes, lung macrophages, and CD8+ T-lymphocytes. BRL 50481, at 30 μM, promotes apoptosis in chronic lymphocytic leukemia cells overexpressing PDE7B, suggesting that this compound also acts against PDE7B. BRL 50481 can be used to evaluate the role of PDE7 isoforms in intracellular signaling.

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