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ChemicalBook >> BTO-1

BTO-1

BTO-1 price.
  • $105 - $1069.04
  • Product name: BTO-1
  • CAS: 40647-02-7
  • MF: C9H4N4O4S
  • MW: 264.22
  • EINECS:
  • MDL Number:MFCD11045282
  • Synonyms:BTO-1;5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide;Polo-like Kinase Inhibitor II, BTO-1 ;Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem;2-Benzothiazolecarboxamide, 5-cyano-7-nitro-, 3-oxide
7 prices
Selected condition:
Brand
  • American Custom Chemicals Corporation
  • Sigma-Aldrich
  • TRC
Package
  • 2mg
  • 4mg
  • 5MG
  • 25MG
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001273
  • Product descriptionBTO-1 95.00%
  • Packaging5MG
  • Price$708.94
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001273
  • Product descriptionBTO-1 95.00%
  • Packaging25MG
  • Price$1069.04
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberB6311
  • Product descriptionBTO-1 ≥98% (HPLC), solid
  • Packaging5mg
  • Price$188
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number528283
  • Product descriptionPolo-like Kinase Inhibitor II, BTO-1
  • Packaging2mg
  • Price$259
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberB6311
  • Product descriptionBTO-1 ≥98% (HPLC), solid
  • Packaging25mg
  • Price$589
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberB694340
  • Product descriptionBTO-1
  • Packaging2mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberB694340
  • Product descriptionBTO-1
  • Packaging4mg
  • Price$165
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation KIN0001273 BTO-1 95.00% 5MG $708.94 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001273 BTO-1 95.00% 25MG $1069.04 2021-12-16 Buy
Sigma-Aldrich B6311 BTO-1 ≥98% (HPLC), solid 5mg $188 2024-03-01 Buy
Sigma-Aldrich 528283 Polo-like Kinase Inhibitor II, BTO-1 2mg $259 2024-03-01 Buy
Sigma-Aldrich B6311 BTO-1 ≥98% (HPLC), solid 25mg $589 2024-03-01 Buy
TRC B694340 BTO-1 2mg $105 2021-12-16 Buy
TRC B694340 BTO-1 4mg $165 2021-12-16 Buy

Properties

Boiling point :553.0±60.0 °C(Predicted)
Density :1.89±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :H2O: <2ML/mL
pka :14.67±0.30(Predicted)
form :solid
color :tan

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

BTO-1 is a cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC50 = 8.0 μM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 μM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring.