Bafetinib
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- $41 - $6125
- Product name: Bafetinib
- CAS: 859212-16-1
- MF: C30H31F3N8O
- MW: 576.62
- EINECS:
- MDL Number:MFCD18633200
- Synonyms:Benzamide, N-(3-((4,5'-bipyrimidin)-2-ylamino)-4-methylphenyl)-4-(((3S)-3-(dimethylamino)-1-pyrrolidinyl)methyl)-3-(trifluoromethyl)-;Inno 406;Inno-406;4-[[(3S)-3-Dimethylaminopyrrolidin-1-yl]methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamide;Ns 187;Unii-nvw4Z03I9b;Bafetinib (INNO-406);N-[3-([4,5'-BipyriMidin]-2-ylaMino)-4-Methylphenyl]-4-[[(3S)-3-(diMethylaMino)-1-pyrrolidinyl]Methyl]-3-(trifluoroMethyl)benzaMide
29 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Labseeker
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1179-M010
- Product descriptionBafetinib ≥95%
- Packaging10mg
- Price$335
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1179
- Product descriptionBafetinib
- Packaging1mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA124910
- Product descriptionBafetinib 98+%
- Packaging1mg
- Price$41
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA124910
- Product descriptionBafetinib 98+%
- Packaging5mg
- Price$71
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA124910
- Product descriptionBafetinib 98+%
- Packaging10mg
- Price$92
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA124910
- Product descriptionBafetinib 98+%
- Packaging50mg
- Price$156
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA124910
- Product descriptionBafetinib 98+%
- Packaging100mg
- Price$278
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA124910
- Product descriptionBafetinib 98+%
- Packaging250mg
- Price$555
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA124910
- Product descriptionBafetinib 98+%
- Packaging1g
- Price$1665
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000944
- Product descriptionBAFETINIB 95.00%
- Packaging1MG
- Price$779.63
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000944
- Product descriptionBAFETINIB 95.00%
- Packaging10MG
- Price$2194.5
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2647
- Product descriptionBafetinib
- Packaging10mg
- Price$285
- Updated2021-12-16
- Buy
- ManufacturerAvaChem
- Product number2647
- Product descriptionBafetinib
- Packaging100mg
- Price$1790
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2121
- Product descriptionINNO406-Bafetinib 99%
- Packaging5mg
- Price$148.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180774
- Product descriptionBafetinib (INNO-406) >98%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180774
- Product descriptionBafetinib (INNO-406) >98%
- Packaging250mg
- Price$1060.8
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1179-M010 | Bafetinib ≥95% | 10mg | $335 | 2021-12-16 | Buy |
| AK Scientific | SYN1179 | Bafetinib | 1mg | $120 | 2021-12-16 | Buy |
| Ambeed | A124910 | Bafetinib 98+% | 1mg | $41 | 2021-12-16 | Buy |
| Ambeed | A124910 | Bafetinib 98+% | 5mg | $71 | 2021-12-16 | Buy |
| Ambeed | A124910 | Bafetinib 98+% | 10mg | $92 | 2021-12-16 | Buy |
| Ambeed | A124910 | Bafetinib 98+% | 50mg | $156 | 2021-12-16 | Buy |
| Ambeed | A124910 | Bafetinib 98+% | 100mg | $278 | 2021-12-16 | Buy |
| Ambeed | A124910 | Bafetinib 98+% | 250mg | $555 | 2021-12-16 | Buy |
| Ambeed | A124910 | Bafetinib 98+% | 1g | $1665 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000944 | BAFETINIB 95.00% | 1MG | $779.63 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000944 | BAFETINIB 95.00% | 10MG | $2194.5 | 2021-12-16 | Buy |
| AvaChem | 2647 | Bafetinib | 10mg | $285 | 2021-12-16 | Buy |
| AvaChem | 2647 | Bafetinib | 100mg | $1790 | 2021-12-16 | Buy |
| Axon Medchem | Axon2121 | INNO406-Bafetinib 99% | 5mg | $148.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180774 | Bafetinib (INNO-406) >98% | 100mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180774 | Bafetinib (INNO-406) >98% | 250mg | $1060.8 | 2021-12-16 | Buy |
Properties
Melting point :166-168°C
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO:42.0(Max Conc. mg/mL);72.84(Max Conc. mM)
form :A crystalline solid
pka :12.72±0.70(Predicted)
color :Light yellow to yellow
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO:42.0(Max Conc. mg/mL);72.84(Max Conc. mM)
form :A crystalline solid
pka :12.72±0.70(Predicted)
color :Light yellow to yellow
Safety Information
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Description
Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia (CML). Bafetinib is a rationally developed tyrosine kinase inhibitor based on the chemical structure of imatinib , with modifications added to improve binding and potency against Bcr-Abl kinase (IC50 = 5.8 nM). It is 25- to 55-fold more potent than imatinib in vitro and ≥10-fold more potent in vivo. Bafetinib inhibits 12 out of the 13 most frequent imatinib-resistant Bcr-Abl point mutations, but not the T315I mutation and also targets the Src family kinase Lyn (IC50 = 19 nM), which has been associated with resistance to imatinib in CML.More related product prices
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