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ChemicalBook >> CAS DataBase List >> Bicalutamide

Bicalutamide

Bicalutamide price.
  • $30 - $1593.9
  • Product name: Bicalutamide
  • CAS: 90357-06-5
  • MF: C18H14F4N2O4S
  • MW: 430.37
  • EINECS:200-001-8
  • MDL Number:MFCD00869971
  • Synonyms:(+-)--2-hydroxy-2-methyl ;propanamide,n-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl) ;Bicalutamide (Subject to patent free);ICI-176334;BICALUTAMIDE;N-[(4-CYANO-3-TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)SULFONYL]-2-HYDROXY-2-METHYLPROPANAMIDE;N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)SULFONYL]-2-HYDROXY-2-METHYLPROPIONANILIDE;Bicalutamide&Int.
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Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chem-Impex
  • Crysdot
  • CSNpharm
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • Tocris
  • TRC
  • Usbiological
Package
  • 10mg
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  • 50
  • y0001448
  • 5g
  • y0001444
  • ManufacturerAK Scientific
  • Product numberG387
  • Product descriptionBicalutamide
  • Packaging5g
  • Price$747
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0001710
  • Product descriptionBICALUTAMIDE 95.00%
  • Packaging100MG
  • Price$704.55
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0001710
  • Product descriptionBICALUTAMIDE 95.00%
  • Packaging1G
  • Price$1593.9
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA5065
  • Product descriptionBicalutamide
  • Packaging100mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60394
  • Product descriptionBicalutamide
  • Packaging20mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2621
  • Product descriptionBicalutamide
  • Packaging25mg
  • Price$35
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2621
  • Product descriptionBicalutamide
  • Packaging250mg
  • Price$69
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2621
  • Product descriptionBicalutamide
  • Packaging1g
  • Price$129
  • Updated2021-12-16
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  • ManufacturerAvaChem
  • Product number2621
  • Product descriptionBicalutamide
  • Packaging5g
  • Price$390
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberIC58278
  • Product descriptionBicalutamide
  • Packaging50mg
  • Price$60
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberIC58278
  • Product descriptionBicalutamide
  • Packaging100mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberIC58278
  • Product descriptionBicalutamide
  • Packaging250mg
  • Price$187.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberIC58278
  • Product descriptionBicalutamide
  • Packaging500mg
  • Price$250
  • Updated2021-12-16
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  • ManufacturerBiosynth Carbosynth
  • Product numberIC58278
  • Product descriptionBicalutamide
  • Packaging1g
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14250
  • Product descriptionBicalutamide ≥98%
  • Packaging50mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14250
  • Product descriptionBicalutamide ≥98%
  • Packaging100mg
  • Price$48
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific G387 Bicalutamide 5g $747 2021-12-16 Buy
American Custom Chemicals Corporation API0001710 BICALUTAMIDE 95.00% 100MG $704.55 2021-12-16 Buy
American Custom Chemicals Corporation API0001710 BICALUTAMIDE 95.00% 1G $1593.9 2021-12-16 Buy
ApexBio Technology A5065 Bicalutamide 100mg $50 2021-12-16 Buy
Arctom CFN60394 Bicalutamide 20mg $30 2021-12-16 Buy
AvaChem 2621 Bicalutamide 25mg $35 2021-12-16 Buy
AvaChem 2621 Bicalutamide 250mg $69 2021-12-16 Buy
AvaChem 2621 Bicalutamide 1g $129 2021-12-16 Buy
AvaChem 2621 Bicalutamide 5g $390 2021-12-16 Buy
Biosynth Carbosynth IC58278 Bicalutamide 50mg $60 2021-12-16 Buy
Biosynth Carbosynth IC58278 Bicalutamide 100mg $100 2021-12-16 Buy
Biosynth Carbosynth IC58278 Bicalutamide 250mg $187.5 2021-12-16 Buy
Biosynth Carbosynth IC58278 Bicalutamide 500mg $250 2021-12-16 Buy
Biosynth Carbosynth IC58278 Bicalutamide 1g $320 2021-12-16 Buy
Cayman Chemical 14250 Bicalutamide ≥98% 50mg $32 2024-03-01 Buy
Cayman Chemical 14250 Bicalutamide ≥98% 100mg $48 2024-03-01 Buy

Properties

Melting point :191-193°C
Boiling point :650.3±55.0 °C(Predicted)
Density :1.52±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :11.49±0.29(Predicted)
form :powder
color :White to Off-White
λmax :270nm(CH3CN)(lit.)
Merck :14,1200
InChI :InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChIKey :LKJPYSCBVHEWIU-UHFFFAOYSA-N
SMILES :C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)(=O)C(O)(C)CS(C1=CC=C(F)C=C1)(=O)=O
CAS DataBase Reference :90357-06-5(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P391 Collect spillage. Hazardous to the aquatic environment
P405 Store locked up.

Description

Bicalutamide is a non-steroidal androgen receptor antagonist that binds the androgen receptor (Ki = 12.5 μM; IC50 = 1.2 μM), preventing its activation and subsequent upregulation of androgen responsive genes by androgenic hormones. Bicalutamide is frequently used to examine the role of androgen receptor inactivation in the proliferation of prostate cancer cells and has served as a molecular template for the design and structural optimization of more selective androgen receptor modulators for androgen therapy.

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