Neuromedin B (trifluoroacetate salt)

$85
Product name: Neuromedin B (trifluoroacetate salt)
CAS:
MF: C52H73N15O12S
MW: 1132.29432
EINECS:
MDL Number:
Synonyms:Neuromedin B (trifluoroacetate salt)

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Cayman Chemical

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ManufacturerCayman Chemical
Product number24543
Product descriptionNeuromedin B (trifluoroacetate salt) ≥95%
Packaging1mg
Price$85
Updated2024-03-01
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Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Cayman Chemical	24543	Neuromedin B (trifluoroacetate salt) ≥95%	1mg	$85	2024-03-01	Buy

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Description

Neuromedin B (NMB) is a peptide agonist of the NMB receptor (K_i = 7.4 nM in NCI-H1299 small cell lung cancer cells expressing the human receptor). It displays similar affinity for frog [Phe¹³]bombesin receptors (K_i = 11 nM) and lower affinities for human gastrin-releasing peptide receptor and bombesin receptor subtype 3 (K_is = 440 and 4,800 nM, respectively). Intrathecal administration of NMB (0.1-1 nmol) induces dose-dependent itching behavior in mice. NMB (50 μg, s.c.) reduces serum thyroid stimulating hormone (TSH) by 30% in mice indicating a role in pituitary-thyroid axis function. In rodents, NMB is also involved in mediating stress and fear responses, thermoregulation, and can stimulate the contraction of the uterus and gastrointestinal smooth muscle.

Suppliers and manufacturers

Shanghai Hongye Biotechnology Co. Ltd ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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