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ChemicalBook >> 4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]CARBONYL]PHENYL]-1H-IMIDAZOL-2-AMINE

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]CARBONYL]PHENYL]-1H-IMIDAZOL-2-AMINE

4,5-DIHYDRO-N-[4-[[4-(1-METHYLETHOXY)PHENYL]CARBONYL]PHENYL]-1H-IMIDAZOL-2-AMINE price.
4 prices
Selected condition:
Brand
  • Cayman Chemical
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • ManufacturerCayman Chemical
  • Product number10005913
  • Product descriptionCAY10449 ≥98%
  • Packaging1mg
  • Price$59
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10005913
  • Product descriptionCAY10449 ≥98%
  • Packaging5mg
  • Price$253
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10005913
  • Product descriptionCAY10449 ≥98%
  • Packaging10mg
  • Price$448
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10005913
  • Product descriptionCAY10449 ≥98%
  • Packaging25mg
  • Price$979
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 10005913 CAY10449 ≥98% 1mg $59 2024-03-01 Buy
Cayman Chemical 10005913 CAY10449 ≥98% 5mg $253 2024-03-01 Buy
Cayman Chemical 10005913 CAY10449 ≥98% 10mg $448 2024-03-01 Buy
Cayman Chemical 10005913 CAY10449 ≥98% 25mg $979 2024-03-01 Buy

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Description

Recently, a series of relatively simple compounds were found to be high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. CAY10449 is one of the more potent of these. CAY10449 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki value of about 3 nM. Although CAY10449 was not tested in rats, the related compound CAY10441 shows significant analgesic activity in standard antinociceptive assays.