CRT5
|
- $32 - $800
- Product name: CRT5
- CAS: 1034297-58-9
- MF: C28H30N4O2
- MW: 454.56
- EINECS:
- MDL Number:MFCD29081160
- Synonyms:CRT5;Benzamide, 3-[6-amino-5-(6-ethoxy-2-naphthalenyl)-3-pyridinyl]-N-[2-(dimethylamino)ethyl]-;CRT5 (CRT0066051)
12 prices
Selected condition：
Brand
- AK Scientific
- ApexBio Technology
- Cayman Chemical
- DC Chemicals
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product numberSYN5168
- Product descriptionCRT5
- Packaging50mg
- Price$775
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4165
- Product descriptionCRT5
- Packaging5mg
- Price$158
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4165
- Product descriptionCRT5
- Packaging10mg
- Price$277
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4165
- Product descriptionCRT5
- Packaging25mg
- Price$608
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number18532
- Product descriptionCRT5 ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18532
- Product descriptionCRT5 ≥98%
- Packaging5mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18532
- Product descriptionCRT5 ≥98%
- Packaging10mg
- Price$243
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number18532
- Product descriptionCRT5 ≥98%
- Packaging25mg
- Price$533
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC42667
- Product descriptionCRT5 >98%
- Packaging100mg
- Price$500
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC42667
- Product descriptionCRT5 >98%
- Packaging250mg
- Price$800
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberC782015
- Product descriptionCRT5
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberC782015
- Product descriptionCRT5
- Packaging25mg
- Price$415
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5168 | CRT5 | 50mg | $775 | 2021-12-16 | Buy |
| ApexBio Technology | C4165 | CRT5 | 5mg | $158 | 2021-12-16 | Buy |
| ApexBio Technology | C4165 | CRT5 | 10mg | $277 | 2021-12-16 | Buy |
| ApexBio Technology | C4165 | CRT5 | 25mg | $608 | 2021-12-16 | Buy |
| Cayman Chemical | 18532 | CRT5 ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18532 | CRT5 ≥98% | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 18532 | CRT5 ≥98% | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 18532 | CRT5 ≥98% | 25mg | $533 | 2024-03-01 | Buy |
| DC Chemicals | DC42667 | CRT5 >98% | 100mg | $500 | 2021-12-16 | Buy |
| DC Chemicals | DC42667 | CRT5 >98% | 250mg | $800 | 2021-12-16 | Buy |
| TRC | C782015 | CRT5 | 5mg | $120 | 2021-12-16 | Buy |
| TRC | C782015 | CRT5 | 25mg | $415 | 2021-12-16 | Buy |
Properties
Boiling point :651.2±55.0 °C(Predicted)
Density :1.173±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤2.5mg/ml in DMSO;0.25mg/ml in dimethyl formamide
form :crystalline solid
pka :14.23±0.46(Predicted)
Density :1.173±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤2.5mg/ml in DMSO;0.25mg/ml in dimethyl formamide
form :crystalline solid
pka :14.23±0.46(Predicted)
Safety Information
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Description
Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). It has little effect on a panel of additional kinases when given at 1 μM. CRT5 blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation or PKD autophosphorylation. It also decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis.Suppliers and manufacturers
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ShangHai Biochempartner Co.,Ltd