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ChemicalBook >> CAS DataBase List >> CX6258

CX6258

CX6258 price.
  • $49 - $3136.5
  • Product name: CX6258
  • CAS: 1202916-90-2
  • MF: C26H24ClN3O3
  • MW: 461.94
  • EINECS:
  • MDL Number:MFCD28142834
  • Synonyms:(3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one CX-6258;CX6258 (3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one;CX6258;CX-6258/CX6258;(Z)-5-CHLORO-3-((5-(3-(4-METHYL-1,4-DIAZEPANE-1-CARBONYL)PHENYL)FURAN-2-YL)METHYLENE)INDOLIN-2-ONE.HCL;(3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one;CX-6258, >=98%;CX-6258;CX6258;CX 6258
Price20 Properties Safety Information Description
20 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 1000mg
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1182-M010
  • Product descriptionCX-6258 ≥95%
  • Packaging10mg
  • Price$497
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1182
  • Product descriptionCX6258
  • Packaging1mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1182
  • Product descriptionCX6258
  • Packaging100mg
  • Price$2165
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3337
  • Product descriptionCX-6258
  • Packaging10mg
  • Price$140
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180986
  • Product descriptionCX6258 >98%
  • Packaging100mg
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180986
  • Product descriptionCX6258 >98%
  • Packaging250mg
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb180986
  • Product descriptionCX6258 >98%
  • Packaging1000mg
  • Price$3136.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16245
  • Product descriptionCX-6258 ≥98%
  • Packaging1mg
  • Price$49
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16245
  • Product descriptionCX-6258 ≥98%
  • Packaging5mg
  • Price$96
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16245
  • Product descriptionCX-6258 ≥98%
  • Packaging10mg
  • Price$168
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16245
  • Product descriptionCX-6258 ≥98%
  • Packaging25mg
  • Price$356
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM148917
  • Product description(E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one 95%+
  • Packaging50mg
  • Price$505
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1529
  • Product descriptionCX-6258 99.73%
  • Packaging5mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1529
  • Product descriptionCX-6258 99.73%
  • Packaging10mg
  • Price$192
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1529
  • Product descriptionCX-6258 99.73%
  • Packaging50mg
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004306
  • Product descriptionCX-6258 98+%
  • Packaging50mg
  • Price$440
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1182-M010 CX-6258 ≥95% 10mg $497 2021-12-16 Buy
AK Scientific SYN1182 CX6258 1mg $210 2021-12-16 Buy
AK Scientific SYN1182 CX6258 100mg $2165 2021-12-16 Buy
ApexBio Technology A3337 CX-6258 10mg $140 2021-12-16 Buy
Biorbyt Ltd orb180986 CX6258 >98% 100mg $912.9 2021-12-16 Buy
Biorbyt Ltd orb180986 CX6258 >98% 250mg $1802 2021-12-16 Buy
Biorbyt Ltd orb180986 CX6258 >98% 1000mg $3136.5 2021-12-16 Buy
Cayman Chemical 16245 CX-6258 ≥98% 1mg $49 2024-03-01 Buy
Cayman Chemical 16245 CX-6258 ≥98% 5mg $96 2024-03-01 Buy
Cayman Chemical 16245 CX-6258 ≥98% 10mg $168 2024-03-01 Buy
Cayman Chemical 16245 CX-6258 ≥98% 25mg $356 2024-03-01 Buy
Chemenu CM148917 (E)-5-Chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one 95%+ 50mg $505 2021-12-16 Buy
ChemScene CS-1529 CX-6258 99.73% 5mg $144 2021-12-16 Buy
ChemScene CS-1529 CX-6258 99.73% 10mg $192 2021-12-16 Buy
ChemScene CS-1529 CX-6258 99.73% 50mg $540 2021-12-16 Buy
Crysdot CD31004306 CX-6258 98+% 50mg $440 2021-12-16 Buy
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Properties

Boiling point :697.8±55.0 °C(Predicted)
Density :1.309±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in EtOH; ≥11.15 mg/mL in DMSO; ≥2.575 mg/mL in H2O with gentle warming
form :solid
pka :11.38±0.20(Predicted)
color :Yellow to orange

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

The family of Pim (Provirus Integration site for Moloney murine leukemia virus) proteins are serine/threonine kinases involved in cell survival and cell proliferation. CX-6258 is a potent, reversible inhibitor of Pim-1, -2, and -3 (IC50s = 5, 25, and 16 nM, respectively). It demonstrates excellent selectivity, inhibiting only FLT3 from a panel of 107 additional kinases. CX-6258 dose-dependently blocks the phosphorylation of the Pim targets Bad, 4E-BP1, and NKX3.1. It acts synergistically with the chemotherapeutics doxorubicin and paclitaxel, presumably because CX-6258 impairs Pim-mediated enhanced expression of P-glycoprotein. CX-6258 is orally bioavailable and inhibits the growth of MV4-11 xenografts in mice.

Suppliers and manufacturers

career henan chemical co
CX6258
$1.00 /1KG
CX6258 CAS:1202916-90-2
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