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ChemicalBook >> Cdk4 Inhibitor

Cdk4 Inhibitor

Cdk4 Inhibitor price.
  • $55 - $657
  • Product name: Cdk4 Inhibitor
  • CAS: 546102-60-7
  • MF: C20H10BrN3O2
  • MW: 404.22
  • EINECS:
  • MDL Number:
  • Synonyms:Cd4k Inhibitor;5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 2-bromo-12,13-dihydro-
7 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • TRC
Package
  • 0.5mg
  • 500μg
  • 1mg
  • 5mg
  • ManufacturerAK Scientific
  • Product number9594CN
  • Product descriptionCdk4Inhibitor
  • Packaging5mg
  • Price$657
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0013740
  • Product description2-BROMO-12,13-DIHYDRO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7(6H)-DIONE 95.00%
  • Packaging5MG
  • Price$500.67
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number17648
  • Product descriptionCdk4 Inhibitor ≥90%
  • Packaging500μg
  • Price$68
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17648
  • Product descriptionCdk4 Inhibitor ≥90%
  • Packaging1mg
  • Price$116
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number17648
  • Product descriptionCdk4 Inhibitor ≥90%
  • Packaging5mg
  • Price$502
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberC228125
  • Product descriptionCd4kInhibitor
  • Packaging0.5mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberC228125
  • Product descriptionCd4kInhibitor
  • Packaging5mg
  • Price$340
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 9594CN Cdk4Inhibitor 5mg $657 2021-12-16 Buy
American Custom Chemicals Corporation API0013740 2-BROMO-12,13-DIHYDRO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7(6H)-DIONE 95.00% 5MG $500.67 2021-12-16 Buy
Cayman Chemical 17648 Cdk4 Inhibitor ≥90% 500μg $68 2024-03-01 Buy
Cayman Chemical 17648 Cdk4 Inhibitor ≥90% 1mg $116 2024-03-01 Buy
Cayman Chemical 17648 Cdk4 Inhibitor ≥90% 5mg $502 2024-03-01 Buy
TRC C228125 Cd4kInhibitor 0.5mg $55 2021-12-16 Buy
TRC C228125 Cd4kInhibitor 5mg $340 2021-12-16 Buy

Properties

Density :1.864±0.06 g/cm3(Predicted)
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.25 mg/ml
form :A crystalline solid
pka :10.27±0.20(Predicted)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 value of 0.8 μM. It is selective for cyclin D1/Cdk4, demonstrating 7-fold and 28-fold weaker activity against cyclin E/Cdk2 and cyclin B/Cdk1, respectively, and little activity against calcium/calmodulin-dependent protein kinase II and protein kinase A. This compound has been shown to inhibit HCT-116 and NCI-H460 tumor cell growth (IC50s < 3.0 μM) by blocking retinoblastoma protein phosphorylation and inducing G1 cell cycle arrest.