Cl-Amidine
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- $35 - $600
- Product name: Cl-Amidine
- CAS: 1043444-18-3
- MF: C14H19ClN4O2 ? CF3CO2H
- MW: 424.81
- EINECS:
- MDL Number:MFCD31536783
- Synonyms:Cl-Amidine (trifluoroacetate salt);Cl-amidine TFA;(2S)-5-(2-Chloroethanimidamido)-2-(phenylformamido)pentanamide trifluoroacetic acid salt
6 prices
Selected condition：
Brand
- ApexBio Technology
- Cayman Chemical
- DC Chemicals
Package
- 1mg
- 5mg
- 10mg
- 100mg
- ManufacturerApexBio Technology
- Product numberC3829
- Product descriptionCl-Amidine(trifluoroacetatesalt)
- Packaging5mg
- Price$139
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3829
- Product descriptionCl-Amidine(trifluoroacetatesalt)
- Packaging10mg
- Price$221
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10599
- Product descriptionCl-Amidine (trifluoroacetate salt) ≥95%
- Packaging1mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10599
- Product descriptionCl-Amidine (trifluoroacetate salt) ≥95%
- Packaging5mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number10599
- Product descriptionCl-Amidine (trifluoroacetate salt) ≥95%
- Packaging10mg
- Price$193
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC9725
- Product descriptionCl-amidine >98%
- Packaging100mg
- Price$600
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ApexBio Technology | C3829 | Cl-Amidine(trifluoroacetatesalt) | 5mg | $139 | 2021-12-16 | Buy |
| ApexBio Technology | C3829 | Cl-Amidine(trifluoroacetatesalt) | 10mg | $221 | 2021-12-16 | Buy |
| Cayman Chemical | 10599 | Cl-Amidine (trifluoroacetate salt) ≥95% | 1mg | $35 | 2021-12-16 | Buy |
| Cayman Chemical | 10599 | Cl-Amidine (trifluoroacetate salt) ≥95% | 5mg | $140 | 2021-12-16 | Buy |
| Cayman Chemical | 10599 | Cl-Amidine (trifluoroacetate salt) ≥95% | 10mg | $193 | 2021-12-16 | Buy |
| DC Chemicals | DC9725 | Cl-amidine >98% | 100mg | $600 | 2021-12-16 | Buy |
Properties
storage temp. :under inert gas (nitrogen or Argon) at 2–8 °C
solubility :≤20mg/ml in ethanol;50mg/ml in DMSO;14mg/ml in dimethyl formamide
form :crystalline solid
solubility :≤20mg/ml in ethanol;50mg/ml in DMSO;14mg/ml in dimethyl formamide
form :crystalline solid
Safety Information
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Description
Protein arginine deiminase 4 (PAD4) catalyzes the post-translational modification of arginine residues on histones to form citrulline, which plays a large role in regulating gene expression. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. Cl-amidine is an inhibitor of PAD4 deimination activity with an IC50 value of 5.9 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 13,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Cl-amidine also inhibits PAD1 and PAD3 with IC50 values of 0.8 and 6.2 μM, respectively. Cl-amidine is cytotoxic to HL-60, MCF7, and HT-29 cancer cell lines (IC50s = 0.25, 0.05 and 1 μM, respectively). In a CIA mouse model of inflammatory arthritis, Cl-amidine dose dependently decreases the citrulline content in serum and joints and reduces the development of IgG autoantibodies.Suppliers and manufacturers
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